{
  "description": "Alteplase Dosing for Stroke",
  "_filename": "ActivityDefinition-example-alteplase-dosing.json",
  "package_name": "hl7.fhir.r6.examples",
  "date": null,
  "publisher": "HL7 International / Clinical Decision Support",
  "name": "AlteplaseDosingForStroke",
  "type": null,
  "experimental": null,
  "resourceType": "ActivityDefinition",
  "title": "Alteplase Dosing for Stroke",
  "package_version": "6.0.0-ballot5",
  "extension": [ {
    "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg",
    "valueCode": "cds"
  } ],
  "status": "draft",
  "id": "fd319747-d242-410a-a6ac-0b570dbc2c42",
  "dosageInstruction": {
    "step": [ {
      "component": [ {
        "text": "give 10% of dose over 1 minute",
        "route": {
          "coding": [ {
            "code": "47625008",
            "system": "http://snomed.info/sct",
            "display": "Intravenous use"
          } ]
        },
        "safety": {
          "doseLimit": [ {
            "scope": "administration",
            "valueQuantity": {
              "code": "mg",
              "value": 90,
              "system": "http://unitsofmeasure.org"
            }
          } ]
        },
        "doseAndRate": [ {
          "type": {
            "coding": [ {
              "code": "calculated",
              "system": "http://terminology.hl7.org/CodeSystem/dose-rate-type",
              "display": "Calculated"
            } ]
          },
          "doseQuantity": {
            "code": "mg/kg",
            "value": 0.9,
            "system": "http://unitsofmeasure.org"
          }
        } ]
      } ]
    }, {
      "component": [ {
        "text": "give remaining 90% of dose over 1 hour",
        "route": {
          "coding": [ {
            "code": "47625008",
            "system": "http://snomed.info/sct",
            "display": "Intravenous use"
          } ]
        },
        "safety": {
          "doseLimit": [ {
            "scope": "administration",
            "valueQuantity": {
              "code": "mg",
              "value": 90,
              "system": "http://unitsofmeasure.org"
            }
          } ]
        },
        "doseAndRate": [ {
          "type": {
            "coding": [ {
              "code": "calculated",
              "system": "http://terminology.hl7.org/CodeSystem/dose-rate-type",
              "display": "Calculated"
            } ]
          },
          "doseQuantity": {
            "code": "mg/kg",
            "value": 0.9,
            "system": "http://unitsofmeasure.org"
          }
        } ]
      } ]
    } ],
    "renderedInstruction": "give 10% of dose over 1 minute, give remaining 90% of dose over 1 hour"
  },
  "kind": "MedicationRequest",
  "url": "http://example.org/fhir/ActivityDefinition/example-alteplase-dosing",
  "code": {
    "coding": [ {
      "code": "1155608",
      "system": "http://www.nlm.nih.gov/research/umls/rxnorm",
      "display": "alteplase injectable product"
    } ]
  },
  "identifier": [ {
    "value": "urn:oid:2.16.840.1.113883.4.642.19.3",
    "system": "urn:ietf:rfc:3986"
  } ],
  "intent": "order",
  "version": null,
  "contact": [ {
    "telecom": [ {
      "value": "http://www.hl7.org/Special/committees/dss",
      "system": "url"
    } ]
  } ]
}