description: Mikrosatelliteninstabilität (MSI) ist ein Zustand genetischer Hypermutabilität (Neigung zu Mutationen), der aus einer gestörten DNA-Mismatch-Reparatur (MMR) resultiert.
package_name: de.medizininformatikinitiative.kerndatensatz.molgen
derivation: constraint
name: MII_PR_MolGen_Mikrosatelliteninstabilitaet
type: Observation
elements:
  status: {mustSupport: true, index: 0}
  category: {mustSupport: true, index: 1}
  code: {mustSupport: true, index: 2}
  subject:
    type: Reference
    mustSupport: true
    refers: ['http://hl7.org/fhir/StructureDefinition/Group', 'http://hl7.org/fhir/StructureDefinition/Patient']
    index: 3
  encounter: {mustSupport: true, index: 4}
  value:
    mustSupport: true
    choices: []
    index: 6
    slicing:
      slices:
        valueCodeableConcept:
          match: {}
          schema:
            choices: [valueCodeableConcept]
            index: 8
  valueCodeableConcept:
    type: CodeableConcept
    choiceOf: value
    index: 9
    slicing:
      slices:
        valueCodeableConcept:
          match: {}
          schema: {type: CodeableConcept, choiceOf: value, index: 9}
  component:
    mustSupport: true
    index: 10
    slicing:
      slices:
        conclusion-string:
          match: {}
          schema: {mustSupport: true, index: 10}
package_version: 2025.0.0
class: profile
kind: resource
url: https://www.medizininformatik-initiative.de/fhir/ext/modul-molgen/StructureDefinition/mikrosatelliteninstabilitaet
base: http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/msi
version: 2025.0.0
required: [subject]