{
"description": "Extension of US Core lab result observation to capture attributes specific to solid-phase immuno-assay bead test results.\\r\\n\\r\\nA single bead within a solid phase panel.\\r\\nThis bead usually has a specificity, which may be an allele name or a serological specificity.\\r\\n\\r\\nThe bead has information about it's corresponding positive and negative controls.\\r\\n\\r\\nElements:\\r\\n----------\\r\\n - bead-info: Structure containing details on the specificity and identifiers of an individual bead\\r\\n - raw-data: Structure containing measured MFI or raw data as measured in the assay.\\r\\n - converted-data: Structure containing converted MFIs, formulas used, and interpretations of bead-specific results.\\r\\n\\r\\nbead-info\\r\\n - bead-id\\r\\n - type\\r\\n - control-type\\r\\n - HLA-target-type\\r\\n - HLA-target-serological-specificity\\r\\n - number of beads\\r\\n - sample-raw-MFI\\r\\n - formula\\r\\n - sample-adjusted-MFI\\r\\n - bead-interpretation\\r\\n - bead-plausible\\r\\n - bead-plausible-reason\\r\\n - Ref: working-sample-id\\r\\n - Ref: negative-control-bead-id\\r\\n - negative-control-serum-raw-MFI\\r\\n - negative-control-serum-adjusted-MFI\\r\\n - Ref: negative-control-serum-id\\r\\n - Ref: positive-control-bead-id\\r\\n - positive-control-serum-raw-MFI\\r\\n - positive-control-serum-adjusted-MFI\\r\\n - Ref: positive-control-serum-id",
"_filename": "hla-immuno-assay-bead-observation.StructureDefinition.json",
"package_name": "hla.antibody.report",
"date": null,
"derivation": "constraint",
"publisher": "NMDP",
"fhirVersion": "4.0.1",
"purpose": "Part of HLA Antibody Diagnostic Report implementation guide to capture results specifically for immuno-assay bead results",
"name": "HLAImmunoassayBeadObservation",
"abstract": false,
"type": "Observation",
"experimental": null,
"resourceType": "StructureDefinition",
"title": "HLA Immunoassay Bead Observation",
"package_version": "0.1.2",
"status": "draft",
"id": "bc4b3a78-5c8e-4f31-b115-614170da05ce",
"kind": "resource",
"url": "https://fhir.nmdp.org/ig/HlaAntibodyReport/StructureDefinition/hla-immunoassay-bead-observation",
"version": "0.1.0",
"differential": {
"element": [ {
"id": "Observation.identifier",
"max": "1",
"min": 1,
"path": "Observation.identifier"
}, {
"id": "Observation.identifier.value",
"min": 1,
"path": "Observation.identifier.value",
"label": "Bead Identifier",
"mustSupport": true
}, {
"id": "Observation.partOf.reference",
"min": 1,
"path": "Observation.partOf.reference",
"label": "HLA Antibody Diagnostic Report Ref",
"mustSupport": true
}, {
"id": "Observation.code.coding.system",
"min": 1,
"path": "Observation.code.coding.system",
"binding": {
"strength": "required",
"valueSet": "http://fhir.nmdp.org/terminology/HLAImmunoAssay"
}
}, {
"id": "Observation.focus",
"max": "0",
"path": "Observation.focus"
}, {
"id": "Observation.encounter",
"max": "0",
"path": "Observation.encounter"
}, {
"id": "Observation.value[x]",
"min": 1,
"path": "Observation.value[x]",
"type": [ {
"code": "integer"
} ],
"label": "Raw MFI"
}, {
"id": "Observation.interpretation",
"min": 1,
"path": "Observation.interpretation",
"slicing": {
"rules": "open",
"discriminator": [ {
"path": "$this",
"type": "value"
} ]
}
}, {
"id": "Observation.interpretation:bead-interpretation-classification-entity",
"max": "1",
"path": "Observation.interpretation",
"short": "Bead result classification entity",
"sliceName": "bead-interpretation-classification-entity",
"definition": "Bead observation interpretation indicating the person or entity performing the interpretation of the bead result."
}, {
"id": "Observation.interpretation:bead-interpretation-classification-entity.coding.system",
"max": "0",
"path": "Observation.interpretation.coding.system",
"mustSupport": false
}, {
"id": "Observation.interpretation:bead-interpretation-classification-entity.coding.code",
"max": "0",
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}, {
"id": "Observation.interpretation:bead-interpretation-classification-entity.text",
"min": 1,
"path": "Observation.interpretation.text",
"label": "Classification Entity",
"mustSupport": true
}, {
"id": "Observation.interpretation:bead-interpretation-classification",
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"path": "Observation.interpretation",
"short": "Bead result classification",
"sliceName": "bead-interpretation-classification",
"definition": "Bead observation interpretation indicating the classification of the bead result."
}, {
"id": "Observation.interpretation:bead-interpretation-classification.coding.system",
"min": 1,
"path": "Observation.interpretation.coding.system",
"binding": {
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"valueSet": "http://fhir.nmdp.org/terminology/fhir/CodeSystem/hla-immunoassay-codes"
},
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"id": "Observation.interpretation:bead-interpretation-classification.coding.code",
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"valueSet": "http://fhir.nmdp.org/terminology/hla-antibody-assay/bead-interpretation-classification"
},
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}, {
"id": "Observation.interpretation:bead-interpretation-rank",
"max": "1",
"path": "Observation.interpretation",
"short": "Bead result rank",
"sliceName": "bead-interpretation-rank",
"definition": "Bead observation interpretation indicating the rank of the bead result."
}, {
"id": "Observation.interpretation:bead-interpretation-rank.coding.system",
"min": 1,
"path": "Observation.interpretation.coding.system",
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"valueSet": "http://fhir.nmdp.org/terminology/fhir/CodeSystem/hla-immunoassay-codes"
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"id": "Observation.interpretation:bead-interpretation-rank.coding.code",
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},
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}, {
"id": "Observation.interpretation:bead-plausible",
"max": "1",
"path": "Observation.interpretation",
"short": "Bead result plausibility",
"comment": "Categorical assessment of a laboratory value.",
"sliceName": "bead-plausible",
"definition": "Bead observation interpretation indicating the plausibility of the bead result."
}, {
"id": "Observation.interpretation:bead-plausible.coding",
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"path": "Observation.interpretation.coding.code",
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"valueSet": "http://fhir.nmdp.org/terminology/fhir/ValueSet/hla-immunoassay-boolean"
},
"mustSupport": true
}, {
"id": "Observation.interpretation:bead-plausible-reason",
"max": "1",
"path": "Observation.interpretation",
"short": "Bead result plausibility reason",
"comment": "Categorical assessment of a laboratory value.",
"sliceName": "bead-plausible-reason",
"definition": "Bead observation interpretation indicating the reason code for the plausibility assessment of the bead result."
}, {
"id": "Observation.interpretation:bead-plausible-reason.coding.system",
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"path": "Observation.interpretation.coding.system",
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"valueSet": "http://fhir.nmdp.org/terminology/fhir/ValueSet/hla-immunoassay-bead-plausible-reason"
},
"mustSupport": true
}, {
"id": "Observation.bodySite",
"max": "0",
"path": "Observation.bodySite"
}, {
"id": "Observation.referenceRange",
"max": "0",
"path": "Observation.referenceRange"
}, {
"id": "Observation.component",
"min": 1,
"path": "Observation.component",
"label": "bead-info",
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"rules": "open",
"ordered": false,
"discriminator": [ {
"path": "$this",
"type": "value"
} ]
},
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"id": "Observation.component.code.coding",
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"path": "Observation.component.code.coding"
}, {
"id": "Observation.component.code.coding.system",
"code": [ {
"display": "hla-target-type"
} ],
"path": "Observation.component.code.coding.system"
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"fixedString": "HLA Immuno-assay Bead Information",
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"id": "Observation.component:bead-hla-target-type.code.coding.display",
"path": "Observation.component.code.coding.display",
"label": "hla-target-serological-specificity"
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}, {
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},
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}, {
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"code": "integer"
} ]
}, {
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}, {
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} ],
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} ]
},
"contact": [ {
"name": "David Wroe",
"telecom": [ {
"use": "work",
"value": "dwroe@nmdp.org",
"system": "email"
} ]
} ],
"baseDefinition": "http://hl7.org/fhir/us/core/StructureDefinition/us-core-observation-lab"
}