{
  "description": "The class of oligonucleotide, where relevant (e.g. antisense, siRNA, aptamer).",
  "_filename": "CodeSystem-oligo-nucleotide-type.json",
  "package_name": "hl7.fhir.r6.examples",
  "date": "2026-06-21",
  "meta": {
    "lastUpdated": "2026-07-17T17:22:54.721+10:00"
  },
  "publisher": "HL7 (FHIR Project)",
  "jurisdiction": [ {
    "coding": [ {
      "code": "001",
      "system": "http://unstats.un.org/unsd/methods/m49/m49.htm",
      "display": "World"
    } ]
  } ],
  "content": "complete",
  "name": "OligoNucleotideTypeExample",
  "type": null,
  "experimental": "true",
  "resourceType": "CodeSystem",
  "title": "Oligonucleotide Type",
  "package_version": "6.0.0-ballot5",
  "extension": [ {
    "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg",
    "valueCode": "brr"
  }, {
    "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status",
    "valueCode": "informative"
  }, {
    "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm",
    "valueInteger": 1
  } ],
  "status": "active",
  "id": "ad27efe0-ab43-4603-bbba-e69a3d2a78f4",
  "valueSet": "http://hl7.org/fhir/ValueSet/oligo-nucleotide-type",
  "kind": null,
  "url": "http://hl7.org/fhir/oligo-nucleotide-type",
  "concept": [ {
    "code": "antisense",
    "display": "Antisense oligonucleotide",
    "definition": "An antisense oligonucleotide (ASO) that binds to a complementary mRNA sequence to inhibit gene expression."
  }, {
    "code": "sirna",
    "display": "Small interfering RNA (siRNA)",
    "definition": "A short double-stranded RNA that triggers degradation of a target mRNA through the RNA interference pathway."
  }, {
    "code": "mirna",
    "display": "MicroRNA (miRNA)",
    "definition": "A short non-coding RNA that regulates gene expression by base-pairing with target mRNAs."
  }, {
    "code": "aptamer",
    "display": "Aptamer",
    "definition": "A short single-stranded oligonucleotide that binds a specific target through its three-dimensional structure."
  }, {
    "code": "decoy",
    "display": "Decoy oligonucleotide",
    "definition": "An oligonucleotide that mimics a regulatory binding site to sequester a transcription factor or other binding protein."
  }, {
    "code": "ribozyme",
    "display": "Ribozyme / DNAzyme",
    "definition": "A catalytic oligonucleotide capable of cleaving a target nucleic acid."
  }, {
    "code": "gene-fragment",
    "display": "Gene fragment",
    "definition": "A fragment of a gene such as a promoter, enhancer, coding region or silencer."
  } ],
  "caseSensitive": true,
  "version": "6.0.0-ballot5",
  "contact": [ {
    "telecom": [ {
      "value": "http://hl7.org/fhir",
      "system": "url"
    }, {
      "value": "fhir@lists.hl7.org",
      "system": "email"
    } ]
  } ]
}