{
  "description": "Stellt einen gefundenden Biomarker dar. Das Profil ist auf Basis von https://build.fhir.org/ig/HL7/genomics-reporting/StructureDefinition-molecular-biomarker.html nachgebaut.",
  "_filename": "StructureDefinition-mii-pr-mtb-molekularer-biomarker.json",
  "package_name": "de.medizininformatikinitiative.kerndatensatz.mtb",
  "date": null,
  "derivation": "constraint",
  "publisher": "Medizininformatik Initiative",
  "fhirVersion": "4.0.1",
  "name": "MII_PR_MTB_Molekularer_Biomarker",
  "abstract": false,
  "type": "Observation",
  "experimental": null,
  "resourceType": "StructureDefinition",
  "title": "MII PR MTB Molekularer Biomarker",
  "package_version": "2025.0.0-ballot-alpha.1",
  "status": "draft",
  "id": "91985858-1ded-4124-a3b5-4ef10b9ae66d",
  "kind": "resource",
  "url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-molekularer-biomarker",
  "version": "2024.0.0-ballot",
  "differential": {
    "element": [ {
      "id": "Observation.meta",
      "path": "Observation.meta",
      "mustSupport": true
    }, {
      "id": "Observation.category",
      "min": 2,
      "path": "Observation.category",
      "slicing": {
        "rules": "open",
        "ordered": false,
        "description": "Slices for category",
        "discriminator": [ {
          "path": "coding",
          "type": "value"
        } ]
      }
    }, {
      "id": "Observation.category:labCategory",
      "max": "1",
      "min": 1,
      "path": "Observation.category",
      "sliceName": "labCategory",
      "mustSupport": true
    }, {
      "id": "Observation.category:labCategory.coding.system",
      "min": 1,
      "path": "Observation.category.coding.system",
      "patternUri": "http://terminology.hl7.org/CodeSystem/observation-category"
    }, {
      "id": "Observation.category:labCategory.coding.code",
      "min": 1,
      "path": "Observation.category.coding.code",
      "patternCode": "laboratory"
    }, {
      "id": "Observation.category:biomarker-category",
      "max": "1",
      "min": 0,
      "path": "Observation.category",
      "sliceName": "biomarker-category",
      "mustSupport": true
    }, {
      "id": "Observation.category:biomarker-category.coding.system",
      "min": 1,
      "path": "Observation.category.coding.system",
      "patternUri": "$molecular-biomarker-category"
    }, {
      "id": "Observation.category:geCategory",
      "max": "1",
      "min": 1,
      "path": "Observation.category",
      "sliceName": "geCategory"
    }, {
      "id": "Observation.category:geCategory.coding.system",
      "min": 1,
      "path": "Observation.category.coding.system",
      "patternUri": "http://terminology.hl7.org/CodeSystem/v2-0074"
    }, {
      "id": "Observation.category:geCategory.coding.code",
      "min": 1,
      "path": "Observation.category.coding.code",
      "patternCode": "GE"
    }, {
      "id": "Observation.code",
      "path": "Observation.code",
      "binding": {
        "strength": "extensible",
        "valueSet": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/ValueSet/mii-vs-mtb-molekulare-biomarker"
      }
    }, {
      "id": "Observation.derivedFrom",
      "path": "Observation.derivedFrom",
      "slicing": {
        "rules": "open",
        "ordered": false,
        "description": "Slices for derivedFrom",
        "discriminator": [ {
          "path": "resolve()",
          "type": "profile"
        } ]
      }
    }, {
      "id": "Observation.derivedFrom:variant",
      "max": "*",
      "min": 0,
      "path": "Observation.derivedFrom",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant" ]
      } ],
      "sliceName": "variant"
    }, {
      "id": "Observation.derivedFrom:genotype",
      "max": "*",
      "min": 0,
      "path": "Observation.derivedFrom",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genotype" ]
      } ],
      "sliceName": "genotype"
    }, {
      "id": "Observation.derivedFrom:haplotype",
      "max": "*",
      "min": 0,
      "path": "Observation.derivedFrom",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/haplotype" ]
      } ],
      "sliceName": "haplotype"
    }, {
      "id": "Observation.component",
      "path": "Observation.component",
      "slicing": {
        "rules": "open",
        "ordered": false,
        "description": "Slices for component",
        "discriminator": [ {
          "path": "code",
          "type": "value"
        } ]
      }
    }, {
      "id": "Observation.component:gene-studied",
      "max": "*",
      "min": 0,
      "path": "Observation.component",
      "sliceName": "gene-studied"
    }, {
      "id": "Observation.component:gene-studied.code.coding.system",
      "path": "Observation.component.code.coding.system",
      "patternUri": "http://loinc.org"
    }, {
      "id": "Observation.component:gene-studied.code.coding.code",
      "path": "Observation.component.code.coding.code",
      "patternCode": "48018-6"
    }, {
      "id": "Observation.component:gene-studied.value[x]",
      "path": "Observation.component.value[x]",
      "slicing": {
        "rules": "open",
        "ordered": false,
        "discriminator": [ {
          "path": "$this",
          "type": "type"
        } ]
      }
    }, {
      "id": "Observation.component:gene-studied.value[x]:valueCodeableConcept",
      "max": "1",
      "min": 0,
      "path": "Observation.component.value[x]",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "short": "The HGNC gene symbol is to be used as display text and the HGNC gene ID used as the code. If no HGNC code issued for this gene yet, NCBI gene IDs SHALL be used.",
      "sliceName": "valueCodeableConcept"
    } ]
  },
  "contact": [ {
    "telecom": [ {
      "value": "https://www.medizininformatik-initiative.de",
      "system": "url"
    } ]
  } ],
  "baseDefinition": "http://hl7.org/fhir/StructureDefinition/Observation"
}