{
  "description": "This example uses the StatisticModelIncludeIf extension to represent the model characteristic of Welch's 2-sample t-test if the data is consistent with a normal distribution (based on Shapiro-Wilk test with p-value >= 0.05) and a Wilcoxon Mann-Whitney test if not.",
  "_filename": "Evidence-example-statistic-model-include-if.json",
  "package_name": "hl7.fhir.r6.examples",
  "statistic": [ {
    "statisticType": {
      "coding": [ {
        "code": "STATO:0000457",
        "system": "https://fevir.net/sevco",
        "display": "difference in means"
      } ]
    },
    "modelCharacteristic": [ {
      "code": {
        "text": "Welch's 2-sample t-test"
      },
      "intended": true,
      "extension": [ {
        "url": "http://hl7.org/fhir/StructureDefinition/statistic-model-include-if",
        "extension": [ {
          "url": "attribute",
          "valueCodeableConcept": {
            "text": "data distribution"
          }
        }, {
          "url": "value",
          "valueCodeableConcept": {
            "text": "normal distribution (Shapiro-Wilk test with p-value >= 0.05)"
          }
        } ]
      } ]
    }, {
      "code": {
        "text": "Wilcoxon Mann-Whitney test"
      },
      "intended": true,
      "extension": [ {
        "url": "http://hl7.org/fhir/StructureDefinition/statistic-model-include-if",
        "extension": [ {
          "url": "attribute",
          "valueCodeableConcept": {
            "text": "data distribution"
          }
        }, {
          "url": "value",
          "valueCodeableConcept": {
            "text": "not consistent with normal distribution (Shapiro-Wilk test with p-value < 0.05)"
          }
        } ]
      } ]
    } ]
  } ],
  "date": null,
  "meta": {
    "profile": [ "http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model" ],
    "versionId": "9",
    "lastUpdated": "2025-03-10T14:59:32.227Z"
  },
  "publisher": "HL7 International / Clinical Decision Support",
  "name": null,
  "copyright": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "type": null,
  "experimental": null,
  "resourceType": "Evidence",
  "variableDefinition": [ {
    "description": "Adults with hypertension",
    "variableRole": "population"
  }, {
    "description": "Reversitol vs. Placebo",
    "variableRole": "exposure"
  }, {
    "description": "Change in systolic blood pressure from baseline to 3 months",
    "variableRole": "outcome"
  } ],
  "title": "Example of statistical analysis plan with different statistical test if non-normal distribution",
  "package_version": "6.0.0-ballot3",
  "author": [ {
    "name": "Brian S. Alper, MD, MSPH"
  } ],
  "extension": [ {
    "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg",
    "valueCode": "cds"
  } ],
  "status": "active",
  "id": "ff24f803-d932-4bbf-8d4b-c73f5d2d4e9b",
  "kind": null,
  "url": "https://fevir.net/resources/Evidence/346428",
  "identifier": [ {
    "type": {
      "text": "FEvIR Object Identifier"
    },
    "value": "https://fevir.net/FOI/346428",
    "system": "urn:ietf:rfc:3986",
    "assigner": {
      "display": "Computable Publishing LLC"
    }
  }, {
    "value": "urn:oid:2.16.840.1.113883.4.642.10.6",
    "system": "urn:ietf:rfc:3986"
  } ],
  "version": null,
  "studyDesign": [ {
    "coding": [ {
      "code": "SEVCO:01003",
      "system": "https://fevir.net/sevco",
      "display": "randomized assignment"
    } ]
  } ],
  "contact": [ {
    "telecom": [ {
      "value": "http://www.hl7.org/Special/committees/dss",
      "system": "url"
    } ]
  } ]
}