{
  "description": null,
  "_filename": "ActivityDefinition-example-alteplase-dosing.json",
  "package_name": "hl7.fhir.r5.core",
  "date": null,
  "publisher": null,
  "dosage": [ {
    "text": "give 10% of dose over 1 minute",
    "route": {
      "coding": [ {
        "code": "47625008",
        "system": "http://snomed.info/sct",
        "display": "Intravenous use"
      } ]
    },
    "sequence": 1,
    "doseAndRate": [ {
      "type": {
        "coding": [ {
          "code": "calculated",
          "system": "http://terminology.hl7.org/CodeSystem/dose-rate-type",
          "display": "Calculated"
        } ]
      },
      "doseQuantity": {
        "code": "mg/kg",
        "value": 0.9,
        "system": "http://unitsofmeasure.org"
      }
    } ],
    "maxDosePerAdministration": {
      "code": "mg",
      "value": 90,
      "system": "http://unitsofmeasure.org"
    }
  }, {
    "text": "give remaining 90% of dose over 1 hour",
    "route": {
      "coding": [ {
        "code": "47625008",
        "system": "http://snomed.info/sct",
        "display": "Intravenous use"
      } ]
    },
    "sequence": 2,
    "doseAndRate": [ {
      "type": {
        "coding": [ {
          "code": "calculated",
          "system": "http://terminology.hl7.org/CodeSystem/dose-rate-type",
          "display": "Calculated"
        } ]
      },
      "doseQuantity": {
        "code": "mg/kg",
        "value": 0.9,
        "system": "http://unitsofmeasure.org"
      }
    } ],
    "maxDosePerAdministration": {
      "code": "mg",
      "value": 90,
      "system": "http://unitsofmeasure.org"
    }
  } ],
  "name": "Alteplase Dosing for Stroke",
  "type": null,
  "experimental": null,
  "resourceType": "ActivityDefinition",
  "title": null,
  "package_version": "4.6.0",
  "status": "draft",
  "id": "fdb1867d-84e9-4b2c-8b9c-826e1f2d7c07",
  "kind": "MedicationRequest",
  "url": "http://example.org/fhir/ActivityDefinition/example-alteplase-dosing",
  "code": {
    "coding": [ {
      "code": "1155608",
      "system": "http://www.nlm.nih.gov/research/umls/rxnorm",
      "display": "alteplase injectable product"
    } ]
  },
  "intent": "order",
  "version": null
}