description: Beschreibt die Neigung zu Mutationen aufgrund einer gestörten Fehlpaarungsreparatur (DNA mismatch repair, MMR).
package_name: de.medizininformatikinitiative.kerndatensatz.mtb
derivation: constraint
name: MII_PR_MTB_Mikrosatelliteninstabilitaet
type: Observation
elements:
  status: {mustSupport: true, index: 0}
  subject: {index: 1}
  value:
    mustSupport: true
    choices: [valueQuantity]
    index: 3
  valueQuantity: {type: Quantity, mustSupport: true, choiceOf: value, index: 4}
  interpretation:
    binding: {strength: required, valueSet: 'https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/ValueSet/mii-vs-mtb-msi'}
    mustSupport: true
    index: 5
  method:
    short: IHC|PCR|bioinformatic
    _short:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: IHC|PCR|bioinformatisch}
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: en}
        - {url: content, valueString: IHC|PCR|bioinformatic}
    binding: {strength: preferred, valueSet: 'https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/ValueSet/mii-vs-mtb-msi-method-type'}
    _definition:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: Methode der Untersuchung - IHC oder PCR oder NGS-basierte Untersuchung.}
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: en}
        - {url: content, valueString: Method of examination - IHC or PCR or NGS-based examination.}
    mustSupport: true
    index: 6
  specimen: {mustSupport: true, index: 7}
package_version: 2026.0.1
class: profile
kind: resource
url: https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-mikrosatelliteninstabilitaet
base: https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-molekularer-biomarker
version: 2026.0.1
required: [subject]