description: Immunhistorchemistry report
package_name: de.medizininformatikinitiative.kerndatensatz.mtb
derivation: constraint
name: MII_PR_MTB_Immunohistochemistry_PDL1
type: Observation
elements:
  effective:
    choices: [effectiveDateTime]
    index: 1
  effectiveDateTime: {type: dateTime, choiceOf: effective, index: 2}
  specimen:
    short: Probe
    _short:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: Probe}
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: en}
        - {url: content, valueString: Specimen}
    _definition:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: Probe}
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: en}
        - {url: content, valueString: Specimen}
    index: 3
  component:
    index: 4
    slicing:
      rules: open
      ordered: false
      description: Immunohistochemische Ergebnisse
      discriminator:
      - {path: code, type: value}
      min: null
      slices:
        tps-score:
          match:
            code:
              coding:
              - {code: C184941, system: 'https://nih-ncpi.github.io/ncpi-fhir-ig/CodeSystem-ncit.html', display: PD-L1 Tumor Proportion Score}
          schema:
            short: TPS-Score
            _definition:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: Tumor Proportion Score - TPS - Score fuer PD-L1-Expression in Tumorzellen. Der TPS ist der Anteil der PD-L1-positiven Tumorzellen im Verhaeltnis zu den Gesamtzellen. Der TPS wird in Prozent angegeben. Ein TPS von 1 Prozent oder mehr gilt als positiv.}
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: en}
                - {url: content, valueString: Tumor Proportion Score - TPS - Score for PD-L1 expression in tumor cells. The TPS is the proportion of PD-L1-positive tumor cells relative to total cells. TPS is expressed as a percentage. A TPS of 1 percent or more is considered positive.}
            mustSupport: true
            _short:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: TPS-Score}
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: en}
                - {url: content, valueString: TPS Score}
            index: 5
            elements:
              code:
                mustSupport: true
                pattern:
                  type: CodeableConcept
                  value:
                    coding:
                    - {code: C184941, system: 'https://nih-ncpi.github.io/ncpi-fhir-ig/CodeSystem-ncit.html', display: PD-L1 Tumor Proportion Score}
                index: 6
              value:
                choices: []
                index: 8
                slicing:
                  rules: open
                  ordered: false
                  discriminator:
                  - {path: $this, type: type}
                  min: null
                  slices:
                    valueQuantity:
                      match: {}
                      schema:
                        mustSupport: true
                        choices: [valueQuantity]
                        index: 10
                      min: 0
                      max: 1
              valueQuantity:
                type: Quantity
                mustSupport: true
                choiceOf: value
                index: 11
                slicing:
                  slices:
                    valueQuantity:
                      match: {}
                      schema: {type: Quantity, mustSupport: true, choiceOf: value, index: 11}
                      min: 0
                      max: 1
              interpretation: {mustSupport: true, index: 12}
        cps-score:
          match:
            code:
              coding:
              - {code: C176582, system: 'https://nih-ncpi.github.io/ncpi-fhir-ig/CodeSystem-ncit.html', display: PD-L1 Combined Positive Score}
          schema:
            short: CPS-Score
            _definition:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: Combined Positive Score - CPS - Score fuer PD-L1-Expression in Tumorzellen und Immunzellen. Der CPS ist der Anteil der PD-L1-positiven Tumorzellen und Immunzellen im Verhaeltnis zu den Gesamtzellen. Der CPS wird in Prozent angegeben. Ein CPS von 1 Prozent oder mehr gilt als positiv.}
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: en}
                - {url: content, valueString: Combined Positive Score - CPS - Score for PD-L1 expression in tumor cells and immune cells. The CPS is the proportion of PD-L1-positive tumor cells and immune cells relative to total cells. CPS is expressed as a percentage. A CPS of 1 percent or more is considered positive.}
            mustSupport: true
            _short:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: CPS-Score}
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: en}
                - {url: content, valueString: CPS Score}
            index: 13
            elements:
              code:
                mustSupport: true
                pattern:
                  type: CodeableConcept
                  value:
                    coding:
                    - {code: C176582, system: 'https://nih-ncpi.github.io/ncpi-fhir-ig/CodeSystem-ncit.html', display: PD-L1 Combined Positive Score}
                index: 14
              value:
                choices: []
                index: 16
                slicing:
                  rules: open
                  ordered: false
                  discriminator:
                  - {path: $this, type: type}
                  min: null
                  slices:
                    valueQuantity:
                      match: {}
                      schema:
                        mustSupport: true
                        choices: [valueQuantity]
                        index: 18
                      min: 0
                      max: 1
              valueQuantity:
                type: Quantity
                mustSupport: true
                choiceOf: value
                index: 19
                slicing:
                  slices:
                    valueQuantity:
                      match: {}
                      schema: {type: Quantity, mustSupport: true, choiceOf: value, index: 19}
                      min: 0
                      max: 1
              interpretation: {mustSupport: true, index: 20}
        ics-score:
          match:
            code:
              coding:
              - {code: C199175, system: 'https://nih-ncpi.github.io/ncpi-fhir-ig/CodeSystem-ncit.html', display: Cells.programmed cell death ligand 1/Viable tumor cells in Tissue by Immune stain}
          schema:
            short: ICS-Score
            _definition:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: Immune Cell Score - ICS - Score fuer PD-L1-Expression in Immunzellen. Der ICS ist der Anteil der PD-L1-positiven Immunzellen im Verhaeltnis zu den Gesamtzellen. Der ICS wird in Prozent angegeben. Ein ICS von 1 Prozent oder mehr gilt als positiv.}
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: en}
                - {url: content, valueString: Immune Cell Score - ICS - Score for PD-L1 expression in immune cells. The ICS is the proportion of PD-L1-positive immune cells relative to total cells. ICS is expressed as a percentage. An ICS of 1 percent or more is considered positive.}
            mustSupport: true
            _short:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: ICS-Score}
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: en}
                - {url: content, valueString: ICS Score}
            index: 21
            elements:
              code:
                mustSupport: true
                pattern:
                  type: CodeableConcept
                  value:
                    coding:
                    - {code: C199175, system: 'https://nih-ncpi.github.io/ncpi-fhir-ig/CodeSystem-ncit.html', display: Cells.programmed cell death ligand 1/Viable tumor cells in Tissue by Immune stain}
                index: 22
              value:
                choices: []
                index: 24
                slicing:
                  rules: open
                  ordered: false
                  discriminator:
                  - {path: $this, type: type}
                  min: null
                  slices:
                    valueQuantity:
                      match: {}
                      schema:
                        mustSupport: true
                        choices: [valueQuantity]
                        index: 26
                      min: 0
                      max: 1
              valueQuantity:
                type: Quantity
                mustSupport: true
                choiceOf: value
                index: 27
                slicing:
                  slices:
                    valueQuantity:
                      match: {}
                      schema: {type: Quantity, mustSupport: true, choiceOf: value, index: 27}
                      min: 0
                      max: 1
              interpretation: {mustSupport: true, index: 28}
        tc-score:
          match:
            code:
              coding:
              - {code: 83053-9, system: 'http://loinc.org', display: Cells.programmed cell death ligand 1/Viable tumor cells in Tissue by Immune stain}
          schema:
            short: TC-Score / TPS-Score
            _definition:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: Tumor Cell Score - TC-Score - Score fuer PD-L1-Expression in Tumorzellen. Der TC-Score ist der Anteil der PD-L1-positiven Tumorzellen im Verhaeltnis zu den Gesamtzellen. Der TC-Score wird in Prozent angegeben. Ein TC-Score von 1 Prozent oder mehr gilt als positiv.}
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: en}
                - {url: content, valueString: Tumor Cell Score - TC-Score - Score for PD-L1 expression in tumor cells. The TC-Score is the proportion of PD-L1-positive tumor cells relative to total cells. TC-Score is expressed as a percentage. A TC-Score of 1 percent or more is considered positive.}
            mustSupport: true
            _short:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: TC-Score / TPS-Score}
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: en}
                - {url: content, valueString: TC Score / TPS Score}
            index: 29
            elements:
              code:
                mustSupport: true
                pattern:
                  type: CodeableConcept
                  value:
                    coding:
                    - {code: 83053-9, system: 'http://loinc.org', display: Cells.programmed cell death ligand 1/Viable tumor cells in Tissue by Immune stain}
                index: 30
              value:
                choices: []
                index: 32
                slicing:
                  rules: open
                  ordered: false
                  discriminator:
                  - {path: $this, type: type}
                  min: null
                  slices:
                    valueQuantity:
                      match: {}
                      schema:
                        mustSupport: true
                        choices: [valueQuantity]
                        index: 34
                      min: 0
                      max: 1
              valueQuantity:
                type: Quantity
                mustSupport: true
                choiceOf: value
                index: 35
                slicing:
                  slices:
                    valueQuantity:
                      match: {}
                      schema: {type: Quantity, mustSupport: true, choiceOf: value, index: 35}
                      min: 0
                      max: 1
              interpretation: {mustSupport: true, index: 36}
package_version: 2026.0.1
class: profile
kind: resource
url: https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry-pdl1
base: https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry
version: 2026.0.1