{
  "description": "Mean HbA1c at 12 months in Ikramuddin 2013 was 6.3 % in Surgery group (n = 57) and 7.8% in Medical/Lifestyle group (n = 19), mean difference -1.50% (95% CI -1.95% to -1.05%)",
  "_filename": "example/Evidence-47751.json",
  "package_name": "hl7.fhir.uv.ebm",
  "statistic": [ {
    "note": [ {
      "text": "Mean HbA1c at 12 months in Ikramuddin 2013 was 6.3 % in Surgery group (n = 57) and 7.8% in Medical/Lifestyle group (n = 57)"
    } ],
    "quantity": {
      "code": "%",
      "unit": "%",
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      "system": "http://unitsofmeasure.org"
    },
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      "numberOfParticipants": 114
    },
    "description": "mean difference -1.50% (95% CI -1.95% to -1.05%)",
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        "system": "http://terminology.hl7.org/CodeSystem/statistic-type",
        "display": "Mean Difference"
      } ]
    },
    "attributeEstimate": [ {
      "type": {
        "coding": [ {
          "code": "C53324",
          "system": "http://terminology.hl7.org/CodeSystem/attribute-estimate-type",
          "display": "Confidence interval"
        } ]
      },
      "level": 0.95,
      "range": {
        "low": {
          "code": "%",
          "unit": "%",
          "value": -1.95,
          "system": "http://unitsofmeasure.org"
        },
        "high": {
          "code": "%",
          "unit": "%",
          "value": -1.05,
          "system": "http://unitsofmeasure.org"
        }
      },
      "description": "95% CI  -1.95% to -1.05%"
    } ]
  } ],
  "date": "2022-05-29T11:03:23.588Z",
  "meta": {
    "profile": [ "http://hl7.org/fhir/uv/ebm/StructureDefinition/comparative-evidence", "http://hl7.org/fhir/uv/ebm/StructureDefinition/single-study-evidence" ],
    "versionId": "18",
    "lastUpdated": "2023-12-06T17:47:29.178Z"
  },
  "publisher": "HL7 International / Clinical Decision Support",
  "name": "ComparativeEvidence_Mean_difference_in_HbA1c_between_Surgery_and_Medical_Lifestyle_groups_in_Ikramuddin_2013",
  "useContext": [ {
    "code": {
      "code": "evidence-communication",
      "system": "https://fevir.net/resources/CodeSystem/179423",
      "display": "Evidence Communication"
    },
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      "coding": [ {
        "code": "ComparativeEvidence",
        "system": "https://fevir.net/resources/CodeSystem/179423",
        "display": "ComparativeEvidence"
      } ]
    }
  }, {
    "code": {
      "code": "evidence-communication",
      "system": "https://fevir.net/resources/CodeSystem/179423",
      "display": "Evidence Communication"
    },
    "valueCodeableConcept": {
      "coding": [ {
        "code": "SingleStudyEvidence",
        "system": "https://fevir.net/resources/CodeSystem/179423",
        "display": "SingleStudyEvidence"
      } ]
    }
  } ],
  "copyright": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "type": null,
  "experimental": null,
  "resourceType": "Evidence",
  "variableDefinition": [ {
    "note": [ {
      "text": "population"
    } ],
    "observed": {
      "type": "Group",
      "display": "Ikramuddin 2013 Trial Enrollment Group"
    },
    "extension": [ {
      "url": "http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code",
      "valueCode": "population"
    } ],
    "description": "114 patients with T2DM and BMI 30 to 39.9 and HbA1c >= 8.0",
    "variableRole": {
      "text": "Use extension:variableRoleCode instead.",
      "coding": [ {
        "code": "population",
        "system": "http://terminology.hl7.org/CodeSystem/variable-role",
        "display": "population"
      } ]
    }
  }, {
    "note": [ {
      "text": "exposure"
    } ],
    "observed": {
      "type": "EvidenceVariable",
      "display": "GroupAssignment: Roux-en-Y gastric bypass surgery vs. Lifestyle-intensive medical management intervention alone",
      "reference": "EvidenceVariable/172481"
    },
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      "url": "http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code",
      "valueCode": "exposure"
    }, {
      "url": "http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category",
      "valueString": "Lifestyle-intensive medical management intervention based on the Diabetes Prevention Program and LookAHEAD trials for 2 years"
    } ],
    "description": "Roux-en-Y Gastric Bypass vs. medical treatment (Lifestyle-intensive medical management intervention LS/IMM)",
    "variableRole": {
      "text": "Use extension:variableRoleCode instead.",
      "coding": [ {
        "code": "exposure",
        "system": "http://terminology.hl7.org/CodeSystem/variable-role",
        "display": "exposure"
      } ]
    }
  }, {
    "note": [ {
      "text": "outcome"
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    "observed": {
      "type": "EvidenceVariable",
      "display": "OutcomeVariable: HbA1c at 12 months",
      "reference": "EvidenceVariable/173243"
    },
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      "url": "http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code",
      "valueCode": "outcome"
    } ],
    "description": "HbA1c at 12 months",
    "variableRole": {
      "text": "Use extension:variableRoleCode instead.",
      "coding": [ {
        "code": "measuredVariable",
        "system": "http://terminology.hl7.org/CodeSystem/variable-role",
        "display": "measured variable"
      } ]
    }
  } ],
  "title": "ComparativeEvidence: Mean difference in HbA1c between Surgery and Medical/Lifestyle groups in Ikramuddin 2013",
  "package_version": "1.0.0-ballot",
  "author": [ {
    "name": "Brian S. Alper"
  } ],
  "synthesisType": {
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      "system": "http://terminology.hl7.org/CodeSystem/synthesis-type",
      "display": "not applicable"
    } ]
  },
  "extension": [ {
    "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg",
    "valueCode": "cds"
  } ],
  "status": "active",
  "id": "ead33655-ca64-4656-95e2-a21fa30ad577",
  "kind": null,
  "url": "https://fevir.net/resources/Evidence/47751",
  "identifier": [ {
    "type": {
      "text": "FEvIR Object Identifier",
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        "code": "ACSN",
        "system": "http://terminology.hl7.org/CodeSystem/v2-0203",
        "display": "Accession ID"
      } ]
    },
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    "system": "https://fevir.net",
    "assigner": {
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    }
  } ],
  "version": "1.0.0-ballot",
  "relatedArtifact": [ {
    "type": "derived-from",
    "label": "data source",
    "display": "Figure 2C",
    "citation": "Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations [Journal Article]. Contributors: Francesco Rubino, David M Nathan, Robert H Eckel, Philip R Schauer, K George M M Alberti, Paul Z Zimmet, Stefano Del Prato, Linong Ji, Shaukat M Sadikot, William H Herman, Stephanie A Amiel, Lee M Kaplan, Gaspar Taroncher-Oldenburg, David E Cummings, Delegates of the 2nd Diabetes Surgery Summit. In: Diabetes care, PMID 27222544. Published June 2016. Available at: https://pubmed.ncbi.nlm.nih.gov/27222544/.",
    "document": {
      "url": "https://diabetesjournals.org/care/article/39/6/861/29305/Metabolic-Surgery-in-the-Treatment-Algorithm-for"
    }
  }, {
    "type": "cite-as",
    "citation": "ComparativeEvidence: Mean difference in HbA1c between Surgery and Medical/Lifestyle groups in Ikramuddin 2013 [Evidence]. Contributors: Brian S. Alper [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 47751. Revised 2022-05-29. Available at: https://fevir.net/resources/Evidence/47751. Computable resource at: https://fevir.net/resources/Evidence/47751."
  } ],
  "studyDesign": [ {
    "coding": [ {
      "code": "SEVCO:01003",
      "system": "https://fevir.net/resources/CodeSystem/181513",
      "display": "randomized assignment"
    } ]
  } ],
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      "system": "url"
    } ]
  } ]
}