{
  "description": "A single evidence for an outcome from a primary study.",
  "_filename": "StructureDefinition-study-outcome-evidence.json",
  "package_name": "de.netzwerk-universitaetsmedizin.ebm-cpg",
  "date": "2022-05-10",
  "derivation": "constraint",
  "publisher": "Netzwerk Universitätsmedizin (NUM)",
  "fhirVersion": "5.0.0",
  "name": "StudyOutcomeEvidence",
  "mapping": [ {
    "uri": "http://hl7.org/fhir/fivews",
    "name": "FiveWs Pattern Mapping",
    "identity": "w5"
  }, {
    "uri": "http://hl7.org/fhir/object-implementation",
    "name": "Object Implementation Information",
    "identity": "objimpl"
  }, {
    "uri": "http://hl7.org/v3",
    "name": "RIM Mapping",
    "identity": "rim"
  } ],
  "abstract": false,
  "type": "Evidence",
  "experimental": null,
  "resourceType": "StructureDefinition",
  "title": "Study Outcome Evidence",
  "package_version": "0.8.0",
  "extension": [ {
    "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-implements",
    "valueUri": "http://hl7.org/fhir/StructureDefinition/MetadataResource"
  } ],
  "snapshot": {
    "element": [ {
      "constraint": [ {
        "key": "cnl-0",
        "human": "Name should be usable as an identifier for the module by machine processing applications such as code generation",
        "source": "http://hl7.org/fhir/StructureDefinition/Evidence",
        "severity": "warning",
        "expression": "name.exists() implies name.matches('^[A-Z]([A-Za-z0-9_]){1,254}$')"
      } ],
      "path": "Evidence",
      "min": 0,
      "definition": "The Evidence Resource provides a machine-interpretable expression of an evidence concept including the evidence variables (e.g., population, exposures/interventions, comparators, outcomes, measured variables, confounding variables), the statistics, and the certainty of this evidence.",
      "isModifier": false,
      "short": "Single evidence bit",
      "mapping": [ {
        "map": "conformance.behavior,clinical.general",
        "identity": "w5"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence"
      },
      "isSummary": false
    }, {
      "path": "Evidence.id",
      "min": 0,
      "definition": "The logical id of the resource, as used in the URL for the resource. Once assigned, this value never changes.",
      "isModifier": false,
      "short": "Logical id of this artifact",
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "id"
        } ]
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.id",
      "comment": "Within the context of the FHIR RESTful interactions, the resource has an id except for cases like the create and conditional update. Otherwise, the use of the resouce id depends on the given use case.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Resource.id"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.meta",
      "min": 0,
      "definition": "The metadata about the resource. This is content that is maintained by the infrastructure. Changes to the content might not always be associated with version changes to the resource.",
      "isModifier": false,
      "short": "Metadata about the resource",
      "type": [ {
        "code": "Meta"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.meta",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Resource.meta"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.implicitRules",
      "min": 0,
      "definition": "A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc.",
      "isModifier": true,
      "short": "A set of rules under which this content was created",
      "type": [ {
        "code": "uri"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.implicitRules",
      "comment": "Asserting this rule set restricts the content to be only understood by a limited set of trading partners. This inherently limits the usefulness of the data in the long term. However, the existing health eco-system is highly fractured, and not yet ready to define, collect, and exchange data in a generally computable sense. Wherever possible, implementers and/or specification writers should avoid using this element. Often, when used, the URL is a reference to an implementation guide that defines these special rules as part of its narrative along with other profiles, value sets, etc.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Resource.implicitRules"
      },
      "isModifierReason": "This element is labeled as a modifier because the implicit rules may provide additional knowledge about the resource that modifies its meaning or interpretation",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.language",
      "min": 0,
      "definition": "The base language in which the resource is written.",
      "isModifier": false,
      "short": "Language of the resource content",
      "type": [ {
        "code": "code"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "required",
        "valueSet": "http://hl7.org/fhir/ValueSet/all-languages|5.0.0",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "Language"
        } ],
        "additional": [ {
          "purpose": "starter",
          "valueSet": "http://hl7.org/fhir/ValueSet/languages"
        } ],
        "description": "IETF language tag for a human language"
      },
      "max": "1",
      "id": "Evidence.language",
      "comment": "Language is provided to support indexing and accessibility (typically, services such as text to speech use the language tag). The html language tag in the narrative applies  to the narrative. The language tag on the resource may be used to specify the language of other presentations generated from the data in the resource. Not all the content has to be in the base language. The Resource.language should not be assumed to apply to the narrative automatically. If a language is specified, it should it also be specified on the div element in the html (see rules in HTML5 for information about the relationship between xml:lang and the html lang attribute).",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Resource.language"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.text",
      "min": 0,
      "definition": "A human-readable narrative that contains a summary of the resource and can be used to represent the content of the resource to a human. The narrative need not encode all the structured data, but is required to contain sufficient detail to make it \"clinically safe\" for a human to just read the narrative. Resource definitions may define what content should be represented in the narrative to ensure clinical safety.",
      "isModifier": false,
      "short": "Text summary of the resource, for human interpretation",
      "mapping": [ {
        "map": "Act.text?",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Narrative"
      } ],
      "mustSupport": false,
      "alias": [ "narrative", "html", "xhtml", "display" ],
      "max": "1",
      "id": "Evidence.text",
      "condition": [ "dom-6" ],
      "comment": "Contained resources do not have a narrative. Resources that are not contained SHOULD have a narrative. In some cases, a resource may only have text with little or no additional discrete data (as long as all minOccurs=1 elements are satisfied).  This may be necessary for data from legacy systems where information is captured as a \"text blob\" or where text is additionally entered raw or narrated and encoded information is added later.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "DomainResource.text"
      },
      "isSummary": false
    }, {
      "path": "Evidence.contained",
      "min": 0,
      "definition": "These resources do not have an independent existence apart from the resource that contains them - they cannot be identified independently, nor can they have their own independent transaction scope. This is allowed to be a Parameters resource if and only if it is referenced by a resource that provides context/meaning.",
      "isModifier": false,
      "short": "Contained, inline Resources",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Resource"
      } ],
      "mustSupport": false,
      "alias": [ "inline resources", "anonymous resources", "contained resources" ],
      "max": "*",
      "id": "Evidence.contained",
      "condition": [ "dom-2", "dom-4", "dom-3", "dom-5" ],
      "comment": "This should never be done when the content can be identified properly, as once identification is lost, it is extremely difficult (and context dependent) to restore it again. Contained resources may have profiles and tags in their meta elements, but SHALL NOT have security labels.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "DomainResource.contained"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the resource. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "mustSupport": false,
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "DomainResource.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the resource and that modifies the understanding of the element that contains it and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "mustSupport": false,
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "DomainResource.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the resource that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "cnl-1",
        "human": "URL should not contain | or # - these characters make processing canonical references problematic",
        "source": "http://hl7.org/fhir/StructureDefinition/Evidence",
        "severity": "warning",
        "expression": "exists() implies matches('^[^|# ]+$')"
      }, {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.url",
      "requirements": "Allows the evidence to be referenced by a single globally unique identifier.",
      "min": 0,
      "definition": "An absolute URI that is used to identify this evidence when it is referenced in a specification, model, design or an instance; also called its canonical identifier. This SHOULD be globally unique and SHOULD be a literal address at which an authoritative instance of this summary is (or will be) published. This URL can be the target of a canonical reference. It SHALL remain the same when the summary is stored on different servers.",
      "isModifier": false,
      "short": "Canonical identifier for this evidence, represented as a globally unique URI",
      "mapping": [ {
        "map": "FiveWs.identifier",
        "identity": "w5"
      } ],
      "type": [ {
        "code": "uri"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.url",
      "comment": "In some cases, the resource can no longer be found at the stated url, but the url itself cannot change. Implementations can use the meta.source element to indicate where the current master source of the resource can be found.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.url"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.identifier",
      "requirements": "Allows externally provided and/or usable business identifiers to be easily associated with the module.",
      "min": 0,
      "definition": "A formal identifier that is used to identify this summary when it is represented in other formats, or referenced in a specification, model, design or an instance.",
      "isModifier": false,
      "short": "Additional identifier for the summary",
      "mapping": [ {
        "map": "FiveWs.identifier",
        "identity": "w5"
      }, {
        "map": "no-gen-base",
        "identity": "objimpl"
      } ],
      "type": [ {
        "code": "Identifier"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.identifier",
      "comment": "Typically, this is used for identifiers that can go in an HL7 V3 II (instance identifier) data type, and can then identify this summary outside of FHIR, where it is not possible to use the logical URI.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.identifier"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.version",
      "min": 0,
      "definition": "The identifier that is used to identify this version of the summary when it is referenced in a specification, model, design or instance. This is an arbitrary value managed by the summary author and is not expected to be globally unique. For example, it might be a timestamp (e.g. yyyymmdd) if a managed version is not available. There is also no expectation that versions can be placed in a lexicographical sequence.",
      "isModifier": false,
      "short": "Business version of this summary",
      "mapping": [ {
        "map": "FiveWs.version",
        "identity": "w5"
      } ],
      "type": [ {
        "code": "string"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.version",
      "comment": "The determination of when to create a new version of a resource (same url, new version) vs. defining a new artifact is up to the author. Considerations for making this decision are found in Technical and Business Versions.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.version"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.versionAlgorithm[x]",
      "min": 0,
      "definition": "Indicates the mechanism used to compare versions to determine which is more current.",
      "isModifier": false,
      "short": "How to compare versions",
      "type": [ {
        "code": "string"
      }, {
        "code": "Coding"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://hl7.org/fhir/ValueSet/version-algorithm"
      },
      "max": "1",
      "id": "Evidence.versionAlgorithm[x]",
      "comment": "If set as a string, this is a FHIRPath expression that has two additional context variables passed in - %version1 and %version2 and will return a negative number if version1 is newer, a positive number if version2 is newer, and a 0 if the version ordering can't successfully be determined.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.versionAlgorithm[x]"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.name",
      "min": 1,
      "definition": "A natural language name identifying the evidence. This name should be usable as an identifier for the module by machine processing applications such as code generation.",
      "isModifier": false,
      "short": "Name for this summary (machine friendly)",
      "type": [ {
        "code": "string"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.name",
      "condition": [ "cnl-0" ],
      "comment": "The name is not expected to be globally unique. The name should be a simple alphanumeric type name to ensure that it is machine-processing friendly.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.name"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.title",
      "min": 0,
      "definition": "A short, descriptive, user-friendly title for the summary.",
      "isModifier": false,
      "short": "Name for this summary (human friendly)",
      "type": [ {
        "code": "string"
      } ],
      "mustSupport": false,
      "extension": [ {
        "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
        "valueBoolean": true
      }, {
        "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
        "valueBoolean": true
      } ],
      "max": "1",
      "id": "Evidence.title",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.title"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.citeAs[x]",
      "min": 0,
      "definition": "Citation Resource or display of suggested citation for this evidence.",
      "isModifier": false,
      "short": "Citation for this evidence",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "http://hl7.org/fhir/StructureDefinition/Citation" ]
      }, {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.citeAs[x]",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.citeAs[x]"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.status",
      "min": 1,
      "definition": "The status of this summary. Enables tracking the life-cycle of the content.",
      "isModifier": true,
      "short": "draft | active | retired | unknown",
      "mapping": [ {
        "map": "FiveWs.status",
        "identity": "w5"
      } ],
      "type": [ {
        "code": "code"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "required",
        "valueSet": "http://hl7.org/fhir/ValueSet/publication-status|5.0.0",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "PublicationStatus"
        } ],
        "description": "The lifecycle status of an artifact."
      },
      "max": "1",
      "id": "Evidence.status",
      "comment": "Allows filtering of summarys s that are appropriate for use versus not.\n\nSee guidance around (not) making local changes to elements [here](canonicalresource.html#localization).",
      "base": {
        "max": "1",
        "min": 1,
        "path": "Evidence.status"
      },
      "isModifierReason": "This is labeled as \"Is Modifier\" because applications should not use a retired {{title}} without due consideration",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.experimental",
      "min": 0,
      "definition": "A Boolean value to indicate that this resource is authored for testing purposes (or education/evaluation/marketing) and is not intended to be used for genuine usage.",
      "isModifier": false,
      "short": "For testing purposes, not real usage",
      "type": [ {
        "code": "boolean"
      } ],
      "mustSupport": false,
      "meaningWhenMissing": "If absent, this resource is treated as though it is not experimental.",
      "max": "1",
      "id": "Evidence.experimental",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.experimental"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.date",
      "min": 0,
      "definition": "The date  (and optionally time) when the summary was last significantly changed. The date must change when the business version changes and it must change if the status code changes. In addition, it should change when the substantive content of the summary changes.",
      "isModifier": false,
      "short": "Date last changed",
      "mapping": [ {
        "map": "FiveWs.recorded",
        "identity": "w5"
      } ],
      "type": [ {
        "code": "dateTime"
      } ],
      "mustSupport": false,
      "alias": [ "Revision Date" ],
      "max": "1",
      "id": "Evidence.date",
      "comment": "The date is often not tracked until the resource is published, but may be present on draft content. Note that this is not the same as the resource last-modified-date, since the resource may be a secondary representation of the summary. Additional specific dates may be added as extensions or be found by consulting Provenances associated with past versions of the resource.\n\nSee guidance around (not) making local changes to elements [here](canonicalresource.html#localization).",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.date"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.approvalDate",
      "min": 0,
      "definition": "The date on which the resource content was approved by the publisher. Approval happens once when the content is officially approved for usage.",
      "isModifier": false,
      "short": "When the summary was approved by publisher",
      "mapping": [ {
        "map": "no-gen-base",
        "identity": "objimpl"
      } ],
      "type": [ {
        "code": "date"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.approvalDate",
      "comment": "The 'date' element may be more recent than the approval date because of minor changes or editorial corrections.\n\nSee guidance around (not) making local changes to elements [here](canonicalresource.html#localization).",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.approvalDate"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.lastReviewDate",
      "requirements": "Gives a sense of how \"current\" the content is.  Resources that have not been reviewed in a long time may have a risk of being less appropriate/relevant.",
      "min": 0,
      "definition": "The date on which the resource content was last reviewed. Review happens periodically after approval but does not change the original approval date.",
      "isModifier": false,
      "short": "When the summary was last reviewed by the publisher",
      "mapping": [ {
        "map": "no-gen-base",
        "identity": "objimpl"
      } ],
      "type": [ {
        "code": "date"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.lastReviewDate",
      "comment": "If specified, this date follows the original approval date.\n\nSee guidance around (not) making local changes to elements [here](canonicalresource.html#localization).",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.lastReviewDate"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.publisher",
      "requirements": "Helps establish the \"authority/credibility\" of the evidence.  May also allow for contact.",
      "min": 0,
      "definition": "The name of the organization or individual responsible for the release and ongoing maintenance of the evidence.",
      "isModifier": false,
      "short": "Name of the publisher/steward (organization or individual)",
      "mapping": [ {
        "map": "FiveWs.witness",
        "identity": "w5"
      } ],
      "type": [ {
        "code": "string"
      } ],
      "mustSupport": false,
      "extension": [ {
        "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
        "valueBoolean": true
      }, {
        "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
        "valueBoolean": true
      } ],
      "max": "1",
      "id": "Evidence.publisher",
      "comment": "Usually an organization but may be an individual. The publisher (or steward) of the evidence is the organization or individual primarily responsible for the maintenance and upkeep of the evidence. This is not necessarily the same individual or organization that developed and initially authored the content. The publisher is the primary point of contact for questions or issues with the evidence. This item SHOULD be populated unless the information is available from context.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.publisher"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.contact",
      "min": 0,
      "definition": "Contact details to assist a user in finding and communicating with the publisher.",
      "isModifier": false,
      "short": "Contact details for the publisher",
      "type": [ {
        "code": "ContactDetail"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.contact",
      "comment": "Extensions to ContactDetail include: contactReference, contactAddress, and contributionTime (see [Clinical Reasoning Module](clinicalreasoning-module.html)).\n\nSee guidance around (not) making local changes to elements [here](canonicalresource.html#localization).",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.contact"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.author",
      "min": 0,
      "definition": "An individiual, organization, or device primarily involved in the creation and maintenance of the content.",
      "isModifier": false,
      "short": "Who authored the content",
      "type": [ {
        "code": "ContactDetail"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.author",
      "comment": "Extensions to ContactDetail include: contactReference, contactAddress, and contributionTime (see [Clinical Reasoning Module](clinicalreasoning-module.html)).",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.author"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.editor",
      "min": 0,
      "definition": "An individiual, organization, or device primarily responsible for internal coherence of the content.",
      "isModifier": false,
      "short": "Who edited the content",
      "type": [ {
        "code": "ContactDetail"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.editor",
      "comment": "Extensions to ContactDetail include: contactReference, contactAddress, and contributionTime (see [Clinical Reasoning Module](clinicalreasoning-module.html)).",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.editor"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.reviewer",
      "min": 0,
      "definition": "An individiual, organization, or device primarily responsible for review of some aspect of the content.",
      "isModifier": false,
      "short": "Who reviewed the content",
      "type": [ {
        "code": "ContactDetail"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.reviewer",
      "comment": "Extensions to ContactDetail include: contactReference, contactAddress, and contributionTime (see [Clinical Reasoning Module](clinicalreasoning-module.html)).\n\nSee guidance around (not) making local changes to elements [here](canonicalresource.html#localization).",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.reviewer"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.endorser",
      "min": 0,
      "definition": "An individiual, organization, or device responsible for officially endorsing the content for use in some setting.",
      "isModifier": false,
      "short": "Who endorsed the content",
      "type": [ {
        "code": "ContactDetail"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.endorser",
      "comment": "Extensions to ContactDetail include: contactReference, contactAddress, and contributionTime (see [Clinical Reasoning Module](clinicalreasoning-module.html)).\n\nSee guidance around (not) making local changes to elements [here](canonicalresource.html#localization).",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.endorser"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.useContext",
      "requirements": "Assist in searching for appropriate content.",
      "min": 0,
      "definition": "The content was developed with a focus and intent of supporting the contexts that are listed. These contexts may be general categories (gender, age, ...) or may be references to specific programs (insurance plans, studies, ...) and may be used to assist with indexing and searching for appropriate evidence instances.",
      "isModifier": false,
      "short": "The context that the content is intended to support",
      "type": [ {
        "code": "UsageContext"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.useContext",
      "comment": "When multiple useContexts are specified, there is no expectation that all or any of the contexts apply.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.useContext"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.purpose",
      "min": 0,
      "definition": "Explanation of why this Evidence is needed and why it has been designed as it has.",
      "isModifier": false,
      "short": "Why this Evidence is defined",
      "mapping": [ {
        "map": "FiveWs.why[x]",
        "identity": "w5"
      }, {
        "map": "no-gen-base",
        "identity": "objimpl"
      } ],
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.purpose",
      "comment": "This element does not describe the usage of the Evidence. Instead, it provides traceability of ''why'' the resource is either needed or ''why'' it is defined as it is. This may be used to point to source materials or specifications that drove the structure of this Evidence.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.purpose"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.copyright",
      "requirements": "Consumers must be able to determine any legal restrictions on the use of the Evidence and/or its content.",
      "min": 0,
      "definition": "A copyright statement relating to the Evidence and/or its contents. Copyright statements are generally legal restrictions on the use and publishing of the Evidence.",
      "isModifier": false,
      "short": "Use and/or publishing restrictions",
      "mapping": [ {
        "map": "no-gen-base",
        "identity": "objimpl"
      } ],
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "alias": [ "License", "Restrictions" ],
      "max": "1",
      "id": "Evidence.copyright",
      "comment": "The short copyright declaration (e.g. (c) '2015+ xyz organization' should be sent in the copyrightLabel element.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.copyright"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.copyrightLabel",
      "requirements": "Defines the content expected to be rendered in all representations of the artifact.",
      "min": 0,
      "definition": "A short string (<50 characters), suitable for inclusion in a page footer that identifies the copyright holder, effective period, and optionally whether rights are resctricted. (e.g. 'All rights reserved', 'Some rights reserved').",
      "isModifier": false,
      "short": "Copyright holder and year(s)",
      "type": [ {
        "code": "string"
      } ],
      "mustSupport": false,
      "extension": [ {
        "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
        "valueBoolean": true
      }, {
        "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
        "valueBoolean": true
      } ],
      "max": "1",
      "id": "Evidence.copyrightLabel",
      "comment": "The (c) symbol should NOT be included in this string. It will be added by software when rendering the notation. Full details about licensing, restrictions, warrantees, etc. goes in the more general 'copyright' element.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.copyrightLabel"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.relatedArtifact",
      "min": 1,
      "definition": "Link or citation to artifact associated with the summary.",
      "isModifier": false,
      "short": "Link or citation to artifact associated with the summary",
      "slicing": {
        "rules": "open",
        "discriminator": [ {
          "path": "type",
          "type": "pattern"
        } ]
      },
      "type": [ {
        "code": "RelatedArtifact"
      } ],
      "mustSupport": true,
      "max": "*",
      "id": "Evidence.relatedArtifact",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.relatedArtifact"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.relatedArtifact",
      "min": 1,
      "definition": "Link or citation to artifact associated with the summary.",
      "isModifier": false,
      "short": "Link or citation to artifact associated with the summary",
      "type": [ {
        "code": "RelatedArtifact"
      } ],
      "mustSupport": true,
      "sliceName": "studyCitation",
      "max": "*",
      "id": "Evidence.relatedArtifact:studyCitation",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.relatedArtifact"
      },
      "isSummary": false
    }, {
      "path": "Evidence.relatedArtifact.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "id"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.relatedArtifact:studyCitation.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.relatedArtifact.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "slicing": {
        "rules": "open",
        "description": "Extensions are always sliced by (at least) url",
        "discriminator": [ {
          "path": "url",
          "type": "value"
        } ]
      },
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.relatedArtifact:studyCitation.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.relatedArtifact.type",
      "min": 1,
      "definition": "The type of relationship to the related artifact.",
      "isModifier": false,
      "short": "documentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as",
      "type": [ {
        "code": "code"
      } ],
      "patternCode": "citation",
      "binding": {
        "strength": "required",
        "valueSet": "http://hl7.org/fhir/ValueSet/related-artifact-type|5.0.0",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "RelatedArtifactType"
        } ],
        "description": "The type of relationship to the related artifact."
      },
      "max": "1",
      "id": "Evidence.relatedArtifact:studyCitation.type",
      "comment": "The presence of both sides of a relationship type (e.g. successor and predecessor) is required to support use cases where one side of a relationship is not represented in FHIR. However, this feature SHALL NOT be used to create bi-directional resource links in FHIR instances. Specifically, following the methodology of \"new points to old\" and \"many points to one\", when using related artifact elements to describe and reference FHIR resources, the type element SHALL be drawn from the fhir-related-artifact-type ValueSet.",
      "base": {
        "max": "1",
        "min": 1,
        "path": "RelatedArtifact.type"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.relatedArtifact.classifier",
      "min": 0,
      "definition": "Provides additional classifiers of the related artifact.",
      "isModifier": false,
      "short": "Additional classifiers",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "binding": {
        "strength": "example",
        "valueSet": "http://hl7.org/fhir/ValueSet/citation-artifact-classifier",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "RelatedArtifactClassifier"
        } ],
        "description": "Additional classifiers for the related artifact."
      },
      "max": "*",
      "id": "Evidence.relatedArtifact:studyCitation.classifier",
      "base": {
        "max": "*",
        "min": 0,
        "path": "RelatedArtifact.classifier"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.relatedArtifact.label",
      "min": 0,
      "definition": "A short label that can be used to reference the citation from elsewhere in the containing artifact, such as a footnote index.",
      "isModifier": false,
      "short": "Short label",
      "type": [ {
        "code": "string"
      } ],
      "max": "1",
      "id": "Evidence.relatedArtifact:studyCitation.label",
      "base": {
        "max": "1",
        "min": 0,
        "path": "RelatedArtifact.label"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.relatedArtifact.display",
      "min": 0,
      "definition": "A brief description of the document or knowledge resource being referenced, suitable for display to a consumer.",
      "isModifier": false,
      "short": "Brief description of the related artifact",
      "type": [ {
        "code": "string"
      } ],
      "max": "1",
      "id": "Evidence.relatedArtifact:studyCitation.display",
      "base": {
        "max": "1",
        "min": 0,
        "path": "RelatedArtifact.display"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.relatedArtifact.citation",
      "min": 0,
      "definition": "A bibliographic citation for the related artifact. This text SHOULD be formatted according to an accepted citation format.",
      "isModifier": false,
      "short": "Bibliographic citation for the artifact",
      "type": [ {
        "code": "markdown"
      } ],
      "max": "1",
      "id": "Evidence.relatedArtifact:studyCitation.citation",
      "comment": "Additional structured information about citations should be captured as extensions.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "RelatedArtifact.citation"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.relatedArtifact.document",
      "min": 0,
      "definition": "The document being referenced, represented as an attachment. This is exclusive with the resource element.",
      "isModifier": false,
      "short": "What document is being referenced",
      "type": [ {
        "code": "Attachment"
      } ],
      "max": "1",
      "id": "Evidence.relatedArtifact:studyCitation.document",
      "base": {
        "max": "1",
        "min": 0,
        "path": "RelatedArtifact.document"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.relatedArtifact.resource",
      "min": 0,
      "definition": "The related artifact, such as a library, value set, profile, or other knowledge resource.",
      "isModifier": false,
      "short": "What artifact is being referenced",
      "type": [ {
        "code": "canonical",
        "targetProfile": [ "http://hl7.org/fhir/StructureDefinition/Resource" ]
      } ],
      "max": "1",
      "id": "Evidence.relatedArtifact:studyCitation.resource",
      "comment": "If the type is predecessor, this is a reference to the succeeding knowledge resource. If the type is successor, this is a reference to the prior knowledge resource.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "RelatedArtifact.resource"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.relatedArtifact.resourceReference",
      "min": 1,
      "definition": "The related artifact, if the artifact is not a canonical resource, or a resource reference to a canonical resource.",
      "isModifier": false,
      "short": "What artifact, if not a conformance resource",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/study-citation" ]
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Evidence.relatedArtifact:studyCitation.resourceReference",
      "comment": "If both resource and resourceReference are present, they SHOULD be consistent and reference the same resource. Although relatedArtifact is intended to support references to definitional resources, there are cases where non-definitional resources can be definitional (such as Location where the kind is mode). Related artifacts SHOULD be used to reference definitional resources, and profiles SHOULD be used to make that explicit for particular use cases.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "RelatedArtifact.resourceReference"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.relatedArtifact.publicationStatus",
      "min": 0,
      "definition": "The publication status of the artifact being referred to.",
      "isModifier": false,
      "short": "draft | active | retired | unknown",
      "type": [ {
        "code": "code"
      } ],
      "binding": {
        "strength": "required",
        "valueSet": "http://hl7.org/fhir/ValueSet/publication-status|5.0.0",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "RelatedArtifactPublicationStatus"
        } ],
        "description": "Publication status of an artifact being referred to."
      },
      "max": "1",
      "id": "Evidence.relatedArtifact:studyCitation.publicationStatus",
      "base": {
        "max": "1",
        "min": 0,
        "path": "RelatedArtifact.publicationStatus"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.relatedArtifact.publicationDate",
      "min": 0,
      "definition": "The date of publication of the artifact being referred to.",
      "isModifier": false,
      "short": "Date of publication of the artifact being referred to",
      "type": [ {
        "code": "date"
      } ],
      "max": "1",
      "id": "Evidence.relatedArtifact:studyCitation.publicationDate",
      "base": {
        "max": "1",
        "min": 0,
        "path": "RelatedArtifact.publicationDate"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.description",
      "min": 0,
      "definition": "A free text natural language description of the evidence from a consumer's perspective.",
      "isModifier": false,
      "short": "Description of the particular summary",
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "extension": [ {
        "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
        "valueBoolean": true
      }, {
        "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
        "valueBoolean": true
      } ],
      "max": "1",
      "id": "Evidence.description",
      "comment": "This description can be used to capture details such as comments about misuse, instructions for clinical use and interpretation, literature references, examples from the paper world, etc. It is not a rendering of the evidence as conveyed in the 'text' field of the resource itself. This item SHOULD be populated unless the information is available from context (e.g. the language of the evidence is presumed to be the predominant language in the place the evidence was created).",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.description"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.assertion",
      "min": 0,
      "definition": "Declarative description of the Evidence.",
      "isModifier": false,
      "short": "Declarative description of the Evidence",
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "extension": [ {
        "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
        "valueBoolean": true
      }, {
        "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
        "valueBoolean": true
      } ],
      "max": "1",
      "id": "Evidence.assertion",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.assertion"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.note",
      "min": 0,
      "definition": "Footnotes and/or explanatory notes.",
      "isModifier": false,
      "short": "Footnotes and/or explanatory notes",
      "type": [ {
        "code": "Annotation"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.note",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.note"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition",
      "min": 2,
      "definition": "Evidence variable such as population, exposure, or outcome.",
      "isModifier": false,
      "short": "Evidence variable such as population, exposure, or outcome",
      "slicing": {
        "rules": "open",
        "discriminator": [ {
          "path": "variableRole",
          "type": "value"
        } ]
      },
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.variableDefinition",
      "base": {
        "max": "*",
        "min": 1,
        "path": "Evidence.variableDefinition"
      },
      "isSummary": false
    }, {
      "path": "Evidence.variableDefinition.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.variableDefinition.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.variableDefinition.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.variableDefinition.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.variableDefinition.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.variableDefinition.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.description",
      "min": 0,
      "definition": "A text description or summary of the variable.",
      "isModifier": false,
      "short": "A text description or summary of the variable",
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.variableDefinition.description",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.variableDefinition.description"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.note",
      "min": 0,
      "definition": "Footnotes and/or explanatory notes.",
      "isModifier": false,
      "short": "Footnotes and/or explanatory notes",
      "type": [ {
        "code": "Annotation"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.variableDefinition.note",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.variableDefinition.note"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.variableRole",
      "min": 1,
      "definition": "population | subpopulation | exposure | referenceExposure | measuredVariable | confounder.",
      "isModifier": false,
      "short": "population | subpopulation | exposure | referenceExposure | measuredVariable | confounder",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://hl7.org/fhir/ValueSet/variable-role",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "EvidenceVariableRole"
        } ],
        "description": "The role that the assertion variable plays."
      },
      "max": "1",
      "id": "Evidence.variableDefinition.variableRole",
      "base": {
        "max": "1",
        "min": 1,
        "path": "Evidence.variableDefinition.variableRole"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.observed",
      "min": 0,
      "definition": "Definition of the actual variable related to the statistic(s).",
      "isModifier": false,
      "short": "Definition of the actual variable related to the statistic(s)",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "http://hl7.org/fhir/StructureDefinition/Group", "http://hl7.org/fhir/StructureDefinition/EvidenceVariable" ]
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.variableDefinition.observed",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.variableDefinition.observed"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.intended",
      "min": 0,
      "definition": "Definition of the intended variable related to the Evidence.",
      "isModifier": false,
      "short": "Definition of the intended variable related to the Evidence",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "http://hl7.org/fhir/StructureDefinition/Group", "http://hl7.org/fhir/StructureDefinition/EvidenceVariable" ]
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.variableDefinition.intended",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.variableDefinition.intended"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.directnessMatch",
      "min": 0,
      "definition": "Indication of quality of match between intended variable to actual variable.",
      "isModifier": false,
      "short": "low | moderate | high | exact",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://terminology.hl7.org/ValueSet/directness",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "EvidenceDirectness"
        } ],
        "description": "The quality of how direct the match is."
      },
      "max": "1",
      "id": "Evidence.variableDefinition.directnessMatch",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.variableDefinition.directnessMatch"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition",
      "min": 1,
      "definition": "Evidence variable such as population, exposure, or outcome.",
      "isModifier": false,
      "short": "Evidence variable such as population, exposure, or outcome",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": true,
      "sliceName": "population",
      "max": "1",
      "id": "Evidence.variableDefinition:population",
      "base": {
        "max": "*",
        "min": 1,
        "path": "Evidence.variableDefinition"
      },
      "isSummary": false
    }, {
      "path": "Evidence.variableDefinition.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.variableDefinition:population.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.variableDefinition.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.variableDefinition:population.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.variableDefinition.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.variableDefinition:population.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.description",
      "min": 0,
      "definition": "A text description or summary of the variable.",
      "isModifier": false,
      "short": "A text description or summary of the variable",
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.variableDefinition:population.description",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.variableDefinition.description"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.note",
      "min": 0,
      "definition": "Footnotes and/or explanatory notes.",
      "isModifier": false,
      "short": "Footnotes and/or explanatory notes",
      "type": [ {
        "code": "Annotation"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.variableDefinition:population.note",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.variableDefinition.note"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.variableRole",
      "min": 1,
      "definition": "population | subpopulation | exposure | referenceExposure | measuredVariable | confounder.",
      "isModifier": false,
      "short": "population | subpopulation | exposure | referenceExposure | measuredVariable | confounder",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://hl7.org/fhir/ValueSet/variable-role",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "EvidenceVariableRole"
        } ],
        "description": "The role that the assertion variable plays."
      },
      "max": "1",
      "id": "Evidence.variableDefinition:population.variableRole",
      "patternCodeableConcept": {
        "coding": [ {
          "code": "population",
          "system": "http://terminology.hl7.org/CodeSystem/variable-role"
        } ]
      },
      "base": {
        "max": "1",
        "min": 1,
        "path": "Evidence.variableDefinition.variableRole"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.observed",
      "min": 1,
      "definition": "Definition of the actual variable related to the statistic(s).",
      "isModifier": false,
      "short": "Definition of the actual variable related to the statistic(s)",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/study-cohort" ]
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Evidence.variableDefinition:population.observed",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.variableDefinition.observed"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.intended",
      "min": 0,
      "definition": "Definition of the intended variable related to the Evidence.",
      "isModifier": false,
      "short": "Definition of the intended variable related to the Evidence",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/study-eligibility-criteria" ]
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.variableDefinition:population.intended",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.variableDefinition.intended"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.directnessMatch",
      "min": 0,
      "definition": "Indication of quality of match between intended variable to actual variable.",
      "isModifier": false,
      "short": "low | moderate | high | exact",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://terminology.hl7.org/ValueSet/directness",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "EvidenceDirectness"
        } ],
        "description": "The quality of how direct the match is."
      },
      "max": "1",
      "id": "Evidence.variableDefinition:population.directnessMatch",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.variableDefinition.directnessMatch"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition",
      "min": 1,
      "definition": "Evidence variable such as population, exposure, or outcome.",
      "isModifier": false,
      "short": "Evidence variable such as population, exposure, or outcome",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": true,
      "sliceName": "outcome",
      "max": "1",
      "id": "Evidence.variableDefinition:outcome",
      "base": {
        "max": "*",
        "min": 1,
        "path": "Evidence.variableDefinition"
      },
      "isSummary": false
    }, {
      "path": "Evidence.variableDefinition.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.variableDefinition:outcome.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.variableDefinition.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.variableDefinition:outcome.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.variableDefinition.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.variableDefinition:outcome.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.description",
      "min": 0,
      "definition": "A text description or summary of the variable.",
      "isModifier": false,
      "short": "A text description or summary of the variable",
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.variableDefinition:outcome.description",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.variableDefinition.description"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.note",
      "min": 0,
      "definition": "Footnotes and/or explanatory notes.",
      "isModifier": false,
      "short": "Footnotes and/or explanatory notes",
      "type": [ {
        "code": "Annotation"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.variableDefinition:outcome.note",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.variableDefinition.note"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.variableRole",
      "min": 1,
      "definition": "population | subpopulation | exposure | referenceExposure | measuredVariable | confounder.",
      "isModifier": false,
      "short": "population | subpopulation | exposure | referenceExposure | measuredVariable | confounder",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://hl7.org/fhir/ValueSet/variable-role",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "EvidenceVariableRole"
        } ],
        "description": "The role that the assertion variable plays."
      },
      "max": "1",
      "id": "Evidence.variableDefinition:outcome.variableRole",
      "patternCodeableConcept": {
        "coding": [ {
          "code": "measuredVariable",
          "system": "http://terminology.hl7.org/CodeSystem/variable-role"
        } ]
      },
      "base": {
        "max": "1",
        "min": 1,
        "path": "Evidence.variableDefinition.variableRole"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.observed",
      "min": 1,
      "definition": "Definition of the actual variable related to the statistic(s).",
      "isModifier": false,
      "short": "Definition of the actual variable related to the statistic(s)",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/outcome-definition" ]
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Evidence.variableDefinition:outcome.observed",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.variableDefinition.observed"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.intended",
      "min": 0,
      "definition": "Definition of the intended variable related to the Evidence.",
      "isModifier": false,
      "short": "Definition of the intended variable related to the Evidence",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "http://hl7.org/fhir/StructureDefinition/Group", "http://hl7.org/fhir/StructureDefinition/EvidenceVariable" ]
      } ],
      "mustSupport": false,
      "max": "0",
      "id": "Evidence.variableDefinition:outcome.intended",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.variableDefinition.intended"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.directnessMatch",
      "min": 0,
      "definition": "Indication of quality of match between intended variable to actual variable.",
      "isModifier": false,
      "short": "low | moderate | high | exact",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://terminology.hl7.org/ValueSet/directness",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "EvidenceDirectness"
        } ],
        "description": "The quality of how direct the match is."
      },
      "max": "1",
      "id": "Evidence.variableDefinition:outcome.directnessMatch",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.variableDefinition.directnessMatch"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition",
      "min": 0,
      "definition": "Evidence variable such as population, exposure, or outcome.",
      "isModifier": false,
      "short": "Evidence variable such as population, exposure, or outcome",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": false,
      "sliceName": "intervention",
      "max": "*",
      "id": "Evidence.variableDefinition:intervention",
      "base": {
        "max": "*",
        "min": 1,
        "path": "Evidence.variableDefinition"
      },
      "isSummary": false
    }, {
      "path": "Evidence.variableDefinition.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.variableDefinition:intervention.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.variableDefinition.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.variableDefinition:intervention.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.variableDefinition.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.variableDefinition:intervention.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.description",
      "min": 0,
      "definition": "A text description or summary of the variable.",
      "isModifier": false,
      "short": "A text description or summary of the variable",
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.variableDefinition:intervention.description",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.variableDefinition.description"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.note",
      "min": 0,
      "definition": "Footnotes and/or explanatory notes.",
      "isModifier": false,
      "short": "Footnotes and/or explanatory notes",
      "type": [ {
        "code": "Annotation"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.variableDefinition:intervention.note",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.variableDefinition.note"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.variableRole",
      "min": 1,
      "definition": "population | subpopulation | exposure | referenceExposure | measuredVariable | confounder.",
      "isModifier": false,
      "short": "population | subpopulation | exposure | referenceExposure | measuredVariable | confounder",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://hl7.org/fhir/ValueSet/variable-role",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "EvidenceVariableRole"
        } ],
        "description": "The role that the assertion variable plays."
      },
      "max": "1",
      "id": "Evidence.variableDefinition:intervention.variableRole",
      "patternCodeableConcept": {
        "coding": [ {
          "code": "exposure",
          "system": "http://terminology.hl7.org/CodeSystem/variable-role"
        } ]
      },
      "base": {
        "max": "1",
        "min": 1,
        "path": "Evidence.variableDefinition.variableRole"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.observed",
      "min": 1,
      "definition": "Definition of the actual variable related to the statistic(s).",
      "isModifier": false,
      "short": "Definition of the actual variable related to the statistic(s)",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/intervention-definition" ]
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Evidence.variableDefinition:intervention.observed",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.variableDefinition.observed"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.intended",
      "min": 0,
      "definition": "Definition of the intended variable related to the Evidence.",
      "isModifier": false,
      "short": "Definition of the intended variable related to the Evidence",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "http://hl7.org/fhir/StructureDefinition/Group", "http://hl7.org/fhir/StructureDefinition/EvidenceVariable" ]
      } ],
      "mustSupport": false,
      "max": "0",
      "id": "Evidence.variableDefinition:intervention.intended",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.variableDefinition.intended"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.directnessMatch",
      "min": 0,
      "definition": "Indication of quality of match between intended variable to actual variable.",
      "isModifier": false,
      "short": "low | moderate | high | exact",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://terminology.hl7.org/ValueSet/directness",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "EvidenceDirectness"
        } ],
        "description": "The quality of how direct the match is."
      },
      "max": "1",
      "id": "Evidence.variableDefinition:intervention.directnessMatch",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.variableDefinition.directnessMatch"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition",
      "min": 0,
      "definition": "Evidence variable such as population, exposure, or outcome.",
      "isModifier": false,
      "short": "Evidence variable such as population, exposure, or outcome",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": false,
      "sliceName": "comparator",
      "max": "*",
      "id": "Evidence.variableDefinition:comparator",
      "base": {
        "max": "*",
        "min": 1,
        "path": "Evidence.variableDefinition"
      },
      "isSummary": false
    }, {
      "path": "Evidence.variableDefinition.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.variableDefinition:comparator.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.variableDefinition.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.variableDefinition:comparator.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.variableDefinition.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.variableDefinition:comparator.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.description",
      "min": 0,
      "definition": "A text description or summary of the variable.",
      "isModifier": false,
      "short": "A text description or summary of the variable",
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.variableDefinition:comparator.description",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.variableDefinition.description"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.note",
      "min": 0,
      "definition": "Footnotes and/or explanatory notes.",
      "isModifier": false,
      "short": "Footnotes and/or explanatory notes",
      "type": [ {
        "code": "Annotation"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.variableDefinition:comparator.note",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.variableDefinition.note"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.variableRole",
      "min": 1,
      "definition": "population | subpopulation | exposure | referenceExposure | measuredVariable | confounder.",
      "isModifier": false,
      "short": "population | subpopulation | exposure | referenceExposure | measuredVariable | confounder",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://hl7.org/fhir/ValueSet/variable-role",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "EvidenceVariableRole"
        } ],
        "description": "The role that the assertion variable plays."
      },
      "max": "1",
      "id": "Evidence.variableDefinition:comparator.variableRole",
      "patternCodeableConcept": {
        "coding": [ {
          "code": "referenceExposure",
          "system": "http://terminology.hl7.org/CodeSystem/variable-role"
        } ]
      },
      "base": {
        "max": "1",
        "min": 1,
        "path": "Evidence.variableDefinition.variableRole"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.observed",
      "min": 1,
      "definition": "Definition of the actual variable related to the statistic(s).",
      "isModifier": false,
      "short": "Definition of the actual variable related to the statistic(s)",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/intervention-definition" ]
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Evidence.variableDefinition:comparator.observed",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.variableDefinition.observed"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.intended",
      "min": 0,
      "definition": "Definition of the intended variable related to the Evidence.",
      "isModifier": false,
      "short": "Definition of the intended variable related to the Evidence",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "http://hl7.org/fhir/StructureDefinition/Group", "http://hl7.org/fhir/StructureDefinition/EvidenceVariable" ]
      } ],
      "mustSupport": false,
      "max": "0",
      "id": "Evidence.variableDefinition:comparator.intended",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.variableDefinition.intended"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.variableDefinition.directnessMatch",
      "min": 0,
      "definition": "Indication of quality of match between intended variable to actual variable.",
      "isModifier": false,
      "short": "low | moderate | high | exact",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://terminology.hl7.org/ValueSet/directness",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "EvidenceDirectness"
        } ],
        "description": "The quality of how direct the match is."
      },
      "max": "1",
      "id": "Evidence.variableDefinition:comparator.directnessMatch",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.variableDefinition.directnessMatch"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.synthesisType",
      "min": 1,
      "definition": "The method to combine studies.",
      "isModifier": false,
      "short": "The method to combine studies",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": true,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://terminology.hl7.org/ValueSet/synthesis-type",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "SynthesisType"
        } ],
        "description": "Types of combining results from a body of evidence (e.g. summary data meta-analysis)."
      },
      "max": "1",
      "id": "Evidence.synthesisType",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.synthesisType"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.studyDesign",
      "min": 0,
      "definition": "The design of the study that produced this evidence. The design is described with any number of study design characteristics.",
      "isModifier": false,
      "short": "The design of the study that produced this evidence",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://hl7.org/fhir/ValueSet/study-design",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "StudyDesign"
        } ],
        "description": "This is a set of terms for study design characteristics."
      },
      "max": "*",
      "id": "Evidence.studyDesign",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.studyDesign"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic",
      "min": 0,
      "definition": "Values and parameters for a single statistic.",
      "isModifier": false,
      "short": "Values and parameters for a single statistic",
      "slicing": {
        "rules": "open",
        "discriminator": [ {
          "path": "statisticType",
          "type": "value"
        } ]
      },
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": true,
      "max": "*",
      "id": "Evidence.statistic",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.statistic.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.description",
      "min": 0,
      "definition": "A description of the content value of the statistic.",
      "isModifier": false,
      "short": "Description of content",
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic.description",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.description"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.note",
      "min": 0,
      "definition": "Footnotes and/or explanatory notes.",
      "isModifier": false,
      "short": "Footnotes and/or explanatory notes",
      "type": [ {
        "code": "Annotation"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic.note",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.note"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.statisticType",
      "min": 0,
      "definition": "Type of statistic, e.g., relative risk.",
      "isModifier": false,
      "short": "Type of statistic, e.g., relative risk",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://hl7.org/fhir/ValueSet/statistic-type",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "StatisticType"
        } ]
      },
      "max": "1",
      "id": "Evidence.statistic.statisticType",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.statisticType"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.category",
      "min": 0,
      "definition": "When the measured variable is handled categorically, the category element is used to define which category the statistic is reporting.",
      "isModifier": false,
      "short": "Associated category for categorical variable",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic.category",
      "comment": "Simple strings can be used for descriptive purposes. Exact matching to EvidenceVariable.category.name for the Evidence.variableDefinition[variableRole=measuredVariable].observed=Reference(EvidenceVariable) could facilitate validation within datasets.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.category"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.quantity",
      "min": 0,
      "definition": "Statistic value.",
      "isModifier": false,
      "short": "Statistic value",
      "type": [ {
        "code": "Quantity"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic.quantity",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.quantity"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.numberOfEvents",
      "min": 0,
      "definition": "The number of events associated with the statistic, where the unit of analysis is different from numberAffected, sampleSize.knownDataCount and sampleSize.numberOfParticipants.",
      "isModifier": false,
      "short": "The number of events associated with the statistic",
      "type": [ {
        "code": "unsignedInt"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic.numberOfEvents",
      "comment": "When the number of events is the statistic, use Evidence.statistic.quantity and set Evidence.statistic.type.coding.code=C25463 and Evidence.statistic.type.coding.display=Count. When the statistic is an Event Rate (where individual participants may have 2 or more events), use Evidence.statistic.numberOfEvents to record the total number of events rather than the number of participants with events.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.numberOfEvents"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.numberAffected",
      "min": 0,
      "definition": "The number of participants affected where the unit of analysis is the same as sampleSize.knownDataCount and sampleSize.numberOfParticipants.",
      "isModifier": false,
      "short": "The number of participants affected",
      "type": [ {
        "code": "unsignedInt"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic.numberAffected",
      "comment": "When the number affected is the statistic, use Evidence.statistic.quantity and set Evidence.statistic.type.coding.code=C25463 and Evidence.statistic.type.coding.display=Count. When the statistic is a Proportion, use Evidence.statistic.numberAffected and enter an integer as the value. When the statistic is an Event Rate (where individual participants may have 2 or more events), use Evidence.statistic.numberAffected to record the number of participants with events rather than the total number of events.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.numberAffected"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize",
      "min": 0,
      "definition": "Number of samples in the statistic.",
      "isModifier": false,
      "short": "Number of samples in the statistic",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic.sampleSize",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.sampleSize"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.sampleSize.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic.sampleSize.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.sampleSize.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic.sampleSize.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.sampleSize.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.statistic.sampleSize.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize.description",
      "min": 0,
      "definition": "Human-readable summary of population sample size.",
      "isModifier": false,
      "short": "Textual description of sample size for statistic",
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic.sampleSize.description",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.sampleSize.description"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize.note",
      "min": 0,
      "definition": "Footnote or explanatory note about the sample size.",
      "isModifier": false,
      "short": "Footnote or explanatory note about the sample size",
      "type": [ {
        "code": "Annotation"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic.sampleSize.note",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.sampleSize.note"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize.numberOfStudies",
      "min": 0,
      "definition": "Number of participants in the population.",
      "isModifier": false,
      "short": "Number of contributing studies",
      "type": [ {
        "code": "unsignedInt"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic.sampleSize.numberOfStudies",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.sampleSize.numberOfStudies"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize.numberOfParticipants",
      "min": 0,
      "definition": "A human-readable string to clarify or explain concepts about the sample size.",
      "isModifier": false,
      "short": "Cumulative number of participants",
      "type": [ {
        "code": "unsignedInt"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic.sampleSize.numberOfParticipants",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.sampleSize.numberOfParticipants"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize.knownDataCount",
      "min": 0,
      "definition": "Number of participants with known results for measured variables.",
      "isModifier": false,
      "short": "Number of participants with known results for measured variables",
      "type": [ {
        "code": "unsignedInt"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic.sampleSize.knownDataCount",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.sampleSize.knownDataCount"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate",
      "min": 0,
      "definition": "A statistical attribute of the statistic such as a measure of heterogeneity.",
      "isModifier": false,
      "short": "An attribute of the Statistic",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic.attributeEstimate",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.attributeEstimate.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic.attributeEstimate.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.attributeEstimate.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic.attributeEstimate.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.attributeEstimate.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.statistic.attributeEstimate.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.description",
      "min": 0,
      "definition": "Human-readable summary of the estimate.",
      "isModifier": false,
      "short": "Textual description of the attribute estimate",
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic.attributeEstimate.description",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.description"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.note",
      "min": 0,
      "definition": "Footnote or explanatory note about the estimate.",
      "isModifier": false,
      "short": "Footnote or explanatory note about the estimate",
      "type": [ {
        "code": "Annotation"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic.attributeEstimate.note",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.note"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type",
      "min": 0,
      "definition": "The type of attribute estimate, e.g., confidence interval or p value.",
      "isModifier": false,
      "short": "The type of attribute estimate, e.g., confidence interval or p value",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://hl7.org/fhir/ValueSet/attribute-estimate-type",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "AttributeEstimateType"
        } ]
      },
      "max": "1",
      "id": "Evidence.statistic.attributeEstimate.type",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.type"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.quantity",
      "min": 0,
      "definition": "The singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure.",
      "isModifier": false,
      "short": "The singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure",
      "type": [ {
        "code": "Quantity"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic.attributeEstimate.quantity",
      "comment": "Often the p value",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.quantity"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.level",
      "min": 0,
      "definition": "Use 95 for a 95% confidence interval.",
      "isModifier": false,
      "short": "Level of confidence interval, e.g., 0.95 for 95% confidence interval",
      "type": [ {
        "code": "decimal"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic.attributeEstimate.level",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.level"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.range",
      "min": 0,
      "definition": "Lower bound of confidence interval.",
      "isModifier": false,
      "short": "Lower and upper bound values of the attribute estimate",
      "type": [ {
        "code": "Range"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic.attributeEstimate.range",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.range"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.attributeEstimate",
      "min": 0,
      "definition": "A nested attribute estimate; which is the attribute estimate of an attribute estimate.",
      "isModifier": false,
      "short": "A nested attribute estimate; which is the attribute estimate of an attribute estimate",
      "contentReference": "http://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate",
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic.attributeEstimate.attributeEstimate",
      "comment": "A nested attribute estimate; which is the attribute estimate of an attribute estimate",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.attributeEstimate"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic",
      "min": 0,
      "definition": "A component of the method to generate the statistic.",
      "isModifier": false,
      "short": "An aspect of the statistical model",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic.modelCharacteristic",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.modelCharacteristic.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic.modelCharacteristic.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic.modelCharacteristic.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.statistic.modelCharacteristic.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.code",
      "min": 1,
      "definition": "Description of a component of the method to generate the statistic.",
      "isModifier": false,
      "short": "Model specification",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://hl7.org/fhir/ValueSet/statistic-model-code",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "StatisticModelCode"
        } ]
      },
      "max": "1",
      "id": "Evidence.statistic.modelCharacteristic.code",
      "base": {
        "max": "1",
        "min": 1,
        "path": "Evidence.statistic.modelCharacteristic.code"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.value",
      "min": 0,
      "definition": "Further specification of the quantified value of the component of the method to generate the statistic.",
      "isModifier": false,
      "short": "Numerical value to complete model specification",
      "type": [ {
        "code": "Quantity",
        "profile": [ "http://hl7.org/fhir/StructureDefinition/SimpleQuantity" ]
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic.modelCharacteristic.value",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.value"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable",
      "min": 0,
      "definition": "A variable adjusted for in the adjusted analysis.",
      "isModifier": false,
      "short": "A variable adjusted for in the adjusted analysis",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic.modelCharacteristic.variable",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.variable"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.modelCharacteristic.variable.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic.modelCharacteristic.variable.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic.modelCharacteristic.variable.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.statistic.modelCharacteristic.variable.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.variableDefinition",
      "min": 1,
      "definition": "Description of the variable.",
      "isModifier": false,
      "short": "Description of the variable",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "http://hl7.org/fhir/StructureDefinition/Group", "http://hl7.org/fhir/StructureDefinition/EvidenceVariable" ]
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic.modelCharacteristic.variable.variableDefinition",
      "base": {
        "max": "1",
        "min": 1,
        "path": "Evidence.statistic.modelCharacteristic.variable.variableDefinition"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.handling",
      "min": 0,
      "definition": "How the variable is classified for use in adjusted analysis.",
      "isModifier": false,
      "short": "continuous | dichotomous | ordinal | polychotomous",
      "type": [ {
        "code": "code"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "required",
        "valueSet": "http://hl7.org/fhir/ValueSet/variable-handling|5.0.0",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "EvidenceVariableHandling"
        } ]
      },
      "max": "1",
      "id": "Evidence.statistic.modelCharacteristic.variable.handling",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.variable.handling"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.valueCategory",
      "min": 0,
      "definition": "Description for grouping of ordinal or polychotomous variables.",
      "isModifier": false,
      "short": "Description for grouping of ordinal or polychotomous variables",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic.modelCharacteristic.variable.valueCategory",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.variable.valueCategory"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.valueQuantity",
      "min": 0,
      "definition": "Discrete value for grouping of ordinal or polychotomous variables.",
      "isModifier": false,
      "short": "Discrete value for grouping of ordinal or polychotomous variables",
      "type": [ {
        "code": "Quantity"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic.modelCharacteristic.variable.valueQuantity",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.variable.valueQuantity"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.valueRange",
      "min": 0,
      "definition": "Range of values for grouping of ordinal or polychotomous variables.",
      "isModifier": false,
      "short": "Range of values for grouping of ordinal or polychotomous variables",
      "type": [ {
        "code": "Range"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic.modelCharacteristic.variable.valueRange",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.variable.valueRange"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.attributeEstimate",
      "min": 0,
      "definition": "An attribute of the statistic used as a model characteristic.",
      "isModifier": false,
      "short": "An attribute of the statistic used as a model characteristic",
      "contentReference": "http://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate",
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic.modelCharacteristic.attributeEstimate",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.attributeEstimate"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic",
      "min": 0,
      "definition": "Values and parameters for a single statistic.",
      "isModifier": false,
      "short": "Values and parameters for a single statistic",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": true,
      "sliceName": "relativeEffect",
      "max": "1",
      "id": "Evidence.statistic:relativeEffect",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.description",
      "min": 1,
      "definition": "A description of the content value of the statistic.",
      "isModifier": false,
      "short": "Description of content",
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.description",
      "patternMarkdown": "Relative effect of intervention vs. comparator",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.description"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.note",
      "min": 0,
      "definition": "Footnotes and/or explanatory notes.",
      "isModifier": false,
      "short": "Footnotes and/or explanatory notes",
      "type": [ {
        "code": "Annotation"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.note",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.note"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.statisticType",
      "min": 1,
      "definition": "Type of statistic, e.g., relative risk.",
      "isModifier": false,
      "short": "Type of statistic, e.g., relative risk",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": true,
      "binding": {
        "strength": "required",
        "valueSet": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/ValueSet/vs-relative-effect-type"
      },
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.statisticType",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.statisticType"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.category",
      "min": 0,
      "definition": "When the measured variable is handled categorically, the category element is used to define which category the statistic is reporting.",
      "isModifier": false,
      "short": "Associated category for categorical variable",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.category",
      "comment": "Simple strings can be used for descriptive purposes. Exact matching to EvidenceVariable.category.name for the Evidence.variableDefinition[variableRole=measuredVariable].observed=Reference(EvidenceVariable) could facilitate validation within datasets.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.category"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.quantity",
      "min": 1,
      "definition": "Statistic value.",
      "isModifier": false,
      "short": "Relative Effect of the presented evidence (intervention vs. comparator) for dichotomous outcomes",
      "type": [ {
        "code": "Quantity"
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.quantity",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.quantity"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.numberOfEvents",
      "min": 0,
      "definition": "The number of events associated with the statistic, where the unit of analysis is different from numberAffected, sampleSize.knownDataCount and sampleSize.numberOfParticipants.",
      "isModifier": false,
      "short": "The number of events associated with the statistic",
      "type": [ {
        "code": "unsignedInt"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.numberOfEvents",
      "comment": "When the number of events is the statistic, use Evidence.statistic.quantity and set Evidence.statistic.type.coding.code=C25463 and Evidence.statistic.type.coding.display=Count. When the statistic is an Event Rate (where individual participants may have 2 or more events), use Evidence.statistic.numberOfEvents to record the total number of events rather than the number of participants with events.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.numberOfEvents"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.numberAffected",
      "min": 0,
      "definition": "The number of participants affected where the unit of analysis is the same as sampleSize.knownDataCount and sampleSize.numberOfParticipants.",
      "isModifier": false,
      "short": "The number of participants affected",
      "type": [ {
        "code": "unsignedInt"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.numberAffected",
      "comment": "When the number affected is the statistic, use Evidence.statistic.quantity and set Evidence.statistic.type.coding.code=C25463 and Evidence.statistic.type.coding.display=Count. When the statistic is a Proportion, use Evidence.statistic.numberAffected and enter an integer as the value. When the statistic is an Event Rate (where individual participants may have 2 or more events), use Evidence.statistic.numberAffected to record the number of participants with events rather than the total number of events.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.numberAffected"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize",
      "min": 1,
      "definition": "Number of samples in the statistic.",
      "isModifier": false,
      "short": "Number of samples in the statistic",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.sampleSize",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.sampleSize"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.sampleSize.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.sampleSize.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.sampleSize.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.sampleSize.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.sampleSize.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.sampleSize.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize.description",
      "min": 0,
      "definition": "Human-readable summary of population sample size.",
      "isModifier": false,
      "short": "Textual description of sample size for statistic",
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.sampleSize.description",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.sampleSize.description"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize.note",
      "min": 0,
      "definition": "Footnote or explanatory note about the sample size.",
      "isModifier": false,
      "short": "Footnote or explanatory note about the sample size",
      "type": [ {
        "code": "Annotation"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.sampleSize.note",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.sampleSize.note"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize.numberOfStudies",
      "min": 1,
      "definition": "Number of participants in the population.",
      "isModifier": false,
      "short": "Number of contributing studies",
      "type": [ {
        "code": "unsignedInt"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.sampleSize.numberOfStudies",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.sampleSize.numberOfStudies"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize.numberOfParticipants",
      "min": 1,
      "definition": "A human-readable string to clarify or explain concepts about the sample size.",
      "isModifier": false,
      "short": "Cumulative number of participants",
      "type": [ {
        "code": "unsignedInt"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.sampleSize.numberOfParticipants",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.sampleSize.numberOfParticipants"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize.knownDataCount",
      "min": 0,
      "definition": "Number of participants with known results for measured variables.",
      "isModifier": false,
      "short": "Number of participants with known results for measured variables",
      "type": [ {
        "code": "unsignedInt"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.sampleSize.knownDataCount",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.sampleSize.knownDataCount"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate",
      "min": 1,
      "definition": "A statistical attribute of the statistic such as a measure of heterogeneity.",
      "isModifier": false,
      "short": "An attribute of the Statistic",
      "slicing": {
        "rules": "open",
        "discriminator": [ {
          "path": "type",
          "type": "value"
        } ]
      },
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": true,
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.attributeEstimate.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.attributeEstimate.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.attributeEstimate.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.description",
      "min": 0,
      "definition": "Human-readable summary of the estimate.",
      "isModifier": false,
      "short": "Textual description of the attribute estimate",
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate.description",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.description"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.note",
      "min": 0,
      "definition": "Footnote or explanatory note about the estimate.",
      "isModifier": false,
      "short": "Footnote or explanatory note about the estimate",
      "type": [ {
        "code": "Annotation"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate.note",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.note"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type",
      "min": 0,
      "definition": "The type of attribute estimate, e.g., confidence interval or p value.",
      "isModifier": false,
      "short": "The type of attribute estimate, e.g., confidence interval or p value",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://hl7.org/fhir/ValueSet/attribute-estimate-type",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "AttributeEstimateType"
        } ]
      },
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate.type",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.type"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.quantity",
      "min": 0,
      "definition": "The singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure.",
      "isModifier": false,
      "short": "The singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure",
      "type": [ {
        "code": "Quantity"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate.quantity",
      "comment": "Often the p value",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.quantity"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.level",
      "min": 0,
      "definition": "Use 95 for a 95% confidence interval.",
      "isModifier": false,
      "short": "Level of confidence interval, e.g., 0.95 for 95% confidence interval",
      "type": [ {
        "code": "decimal"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate.level",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.level"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.range",
      "min": 0,
      "definition": "Lower bound of confidence interval.",
      "isModifier": false,
      "short": "Lower and upper bound values of the attribute estimate",
      "type": [ {
        "code": "Range"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate.range",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.range"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.attributeEstimate",
      "min": 0,
      "definition": "A nested attribute estimate; which is the attribute estimate of an attribute estimate.",
      "isModifier": false,
      "short": "A nested attribute estimate; which is the attribute estimate of an attribute estimate",
      "contentReference": "http://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate",
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate.attributeEstimate",
      "comment": "A nested attribute estimate; which is the attribute estimate of an attribute estimate",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.attributeEstimate"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate",
      "min": 1,
      "definition": "A statistical attribute of the statistic such as a measure of heterogeneity.",
      "isModifier": false,
      "short": "An attribute of the Statistic",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": true,
      "sliceName": "confidenceInterval",
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate:confidenceInterval",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.attributeEstimate.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate:confidenceInterval.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.attributeEstimate.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate:confidenceInterval.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.attributeEstimate.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate:confidenceInterval.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.description",
      "min": 0,
      "definition": "Human-readable summary of the estimate.",
      "isModifier": false,
      "short": "Textual description of the attribute estimate",
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate:confidenceInterval.description",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.description"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.note",
      "min": 0,
      "definition": "Footnote or explanatory note about the estimate.",
      "isModifier": false,
      "short": "Footnote or explanatory note about the estimate",
      "type": [ {
        "code": "Annotation"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate:confidenceInterval.note",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.note"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type",
      "min": 1,
      "definition": "The type of attribute estimate, e.g., confidence interval or p value.",
      "isModifier": false,
      "short": "The type of attribute estimate, e.g., confidence interval or p value",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://hl7.org/fhir/ValueSet/attribute-estimate-type",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "AttributeEstimateType"
        } ]
      },
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate:confidenceInterval.type",
      "patternCodeableConcept": {
        "coding": [ {
          "code": "C53324",
          "system": "http://terminology.hl7.org/CodeSystem/attribute-estimate-type",
          "display": "Confidence interval"
        } ]
      },
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.type"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.attributeEstimate.type.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "id"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate:confidenceInterval.type.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "slicing": {
        "rules": "open",
        "description": "Extensions are always sliced by (at least) url",
        "discriminator": [ {
          "path": "url",
          "type": "value"
        } ]
      },
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate:confidenceInterval.type.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type.coding",
      "requirements": "Allows for alternative encodings within a code system, and translations to other code systems.",
      "min": 0,
      "definition": "A reference to a code defined by a terminology system.",
      "isModifier": false,
      "short": "Code defined by a terminology system",
      "mapping": [ {
        "map": "C*E.1-8, C*E.10-22",
        "identity": "v2"
      }, {
        "map": "union(., ./translation)",
        "identity": "rim"
      }, {
        "map": "fhir:CodeableConcept.coding rdfs:subPropertyOf dt:CD.coding",
        "identity": "orim"
      } ],
      "type": [ {
        "code": "Coding"
      } ],
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate:confidenceInterval.type.coding",
      "comment": "Codes may be defined very casually in enumerations, or code lists, up to very formal definitions such as SNOMED CT - see the HL7 v3 Core Principles for more information.  Ordering of codings is undefined and SHALL NOT be used to infer meaning. Generally, at most only one of the coding values will be labeled as UserSelected = true.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "CodeableConcept.coding"
      },
      "isSummary": true
    }, {
      "path": "Evidence.statistic.attributeEstimate.type.coding.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "id"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate:confidenceInterval.type.coding.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type.coding.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "slicing": {
        "rules": "open",
        "description": "Extensions are always sliced by (at least) url",
        "discriminator": [ {
          "path": "url",
          "type": "value"
        } ]
      },
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate:confidenceInterval.type.coding.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type.coding.system",
      "requirements": "Need to be unambiguous about the source of the definition of the symbol.",
      "min": 1,
      "definition": "The identification of the code system that defines the meaning of the symbol in the code.",
      "isModifier": false,
      "short": "Identity of the terminology system",
      "mapping": [ {
        "map": "C*E.3",
        "identity": "v2"
      }, {
        "map": "./codeSystem",
        "identity": "rim"
      }, {
        "map": "fhir:Coding.system rdfs:subPropertyOf dt:CDCoding.codeSystem",
        "identity": "orim"
      } ],
      "type": [ {
        "code": "uri"
      } ],
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate:confidenceInterval.type.coding.system",
      "comment": "The URI may be an OID (urn:oid:...) or a UUID (urn:uuid:...).  OIDs and UUIDs SHALL be references to the HL7 OID registry. Otherwise, the URI should come from HL7's list of FHIR defined special URIs or it should be an absolute reference to some definition that establishes the system clearly and unambiguously.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Coding.system"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type.coding.version",
      "min": 0,
      "definition": "The version of the code system which was used when choosing this code. Note that a well-maintained code system does not need the version reported, because the meaning of codes is consistent across versions. However this cannot consistently be assured, and when the meaning is not guaranteed to be consistent, the version SHOULD be exchanged.",
      "isModifier": false,
      "short": "Version of the system - if relevant",
      "mapping": [ {
        "map": "C*E.7",
        "identity": "v2"
      }, {
        "map": "./codeSystemVersion",
        "identity": "rim"
      }, {
        "map": "fhir:Coding.version rdfs:subPropertyOf dt:CDCoding.codeSystemVersion",
        "identity": "orim"
      } ],
      "type": [ {
        "code": "string"
      } ],
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate:confidenceInterval.type.coding.version",
      "comment": "Where the terminology does not clearly define what string should be used to identify code system versions, the recommendation is to use the date (expressed in FHIR date format) on which that version was officially published as the version date.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Coding.version"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type.coding.code",
      "requirements": "Need to refer to a particular code in the system.",
      "min": 1,
      "definition": "A symbol in syntax defined by the system. The symbol may be a predefined code or an expression in a syntax defined by the coding system (e.g. post-coordination).",
      "isModifier": false,
      "short": "Symbol in syntax defined by the system",
      "mapping": [ {
        "map": "C*E.1",
        "identity": "v2"
      }, {
        "map": "./code",
        "identity": "rim"
      }, {
        "map": "fhir:Coding.code rdfs:subPropertyOf dt:CDCoding.code",
        "identity": "orim"
      } ],
      "type": [ {
        "code": "code"
      } ],
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate:confidenceInterval.type.coding.code",
      "condition": [ "cod-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Coding.code"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type.coding.display",
      "requirements": "Need to be able to carry a human-readable meaning of the code for readers that do not know  the system.",
      "min": 1,
      "definition": "A representation of the meaning of the code in the system, following the rules of the system.",
      "isModifier": false,
      "short": "Representation defined by the system",
      "mapping": [ {
        "map": "C*E.2 - but note this is not well followed",
        "identity": "v2"
      }, {
        "map": "CV.displayName",
        "identity": "rim"
      }, {
        "map": "fhir:Coding.display rdfs:subPropertyOf dt:CDCoding.displayName",
        "identity": "orim"
      } ],
      "type": [ {
        "code": "string"
      } ],
      "extension": [ {
        "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
        "valueBoolean": true
      } ],
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate:confidenceInterval.type.coding.display",
      "condition": [ "cod-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Coding.display"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type.coding.userSelected",
      "requirements": "This has been identified as a clinical safety criterium - that this exact system/code pair was chosen explicitly, rather than inferred by the system based on some rules or language processing.",
      "min": 0,
      "definition": "Indicates that this coding was chosen by a user directly - e.g. off a pick list of available items (codes or displays).",
      "isModifier": false,
      "short": "If this coding was chosen directly by the user",
      "mapping": [ {
        "map": "Sometimes implied by being first",
        "identity": "v2"
      }, {
        "map": "CD.codingRationale",
        "identity": "rim"
      }, {
        "map": "fhir:Coding.userSelected fhir:mapsTo dt:CDCoding.codingRationale. fhir:Coding.userSelected fhir:hasMap fhir:Coding.userSelected.map. fhir:Coding.userSelected.map a fhir:Map;   fhir:target dt:CDCoding.codingRationale. fhir:Coding.userSelected\\#true a [     fhir:source \"true\";     fhir:target dt:CDCoding.codingRationale\\#O   ]",
        "identity": "orim"
      } ],
      "type": [ {
        "code": "boolean"
      } ],
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate:confidenceInterval.type.coding.userSelected",
      "comment": "Amongst a set of alternatives, a directly chosen code is the most appropriate starting point for new translations. There is some ambiguity about what exactly 'directly chosen' implies, and trading partner agreement may be needed to clarify the use of this element and its consequences more completely.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Coding.userSelected"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type.text",
      "requirements": "The codes from the terminologies do not always capture the correct meaning with all the nuances of the human using them, or sometimes there is no appropriate code at all. In these cases, the text is used to capture the full meaning of the source.",
      "min": 0,
      "definition": "A human language representation of the concept as seen/selected/uttered by the user who entered the data and/or which represents the intended meaning of the user.",
      "isModifier": false,
      "short": "Plain text representation of the concept",
      "mapping": [ {
        "map": "C*E.9. But note many systems use C*E.2 for this",
        "identity": "v2"
      }, {
        "map": "./originalText[mediaType/code=\"text/plain\"]/data",
        "identity": "rim"
      }, {
        "map": "fhir:CodeableConcept.text rdfs:subPropertyOf dt:CD.originalText",
        "identity": "orim"
      } ],
      "type": [ {
        "code": "string"
      } ],
      "extension": [ {
        "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
        "valueBoolean": true
      }, {
        "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
        "valueBoolean": true
      } ],
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate:confidenceInterval.type.text",
      "comment": "Very often the text is the same as a displayName of one of the codings.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "CodeableConcept.text"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.quantity",
      "min": 0,
      "definition": "The singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure.",
      "isModifier": false,
      "short": "The singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure",
      "type": [ {
        "code": "Quantity"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate:confidenceInterval.quantity",
      "comment": "Often the p value",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.quantity"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.level",
      "min": 1,
      "definition": "Use 95 for a 95% confidence interval.",
      "isModifier": false,
      "short": "Level of confidence interval, e.g., 0.95 for 95% confidence interval",
      "type": [ {
        "code": "decimal"
      } ],
      "mustSupport": true,
      "patternDecimal": 0.95,
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate:confidenceInterval.level",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.level"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.range",
      "min": 1,
      "definition": "Relative effect 95% confidence interval.",
      "isModifier": false,
      "short": "Confidence interval of the relative effect",
      "type": [ {
        "code": "Range"
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate:confidenceInterval.range",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.range"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.attributeEstimate",
      "min": 0,
      "definition": "A nested attribute estimate; which is the attribute estimate of an attribute estimate.",
      "isModifier": false,
      "short": "A nested attribute estimate; which is the attribute estimate of an attribute estimate",
      "contentReference": "http://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate",
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.attributeEstimate:confidenceInterval.attributeEstimate",
      "comment": "A nested attribute estimate; which is the attribute estimate of an attribute estimate",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.attributeEstimate"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic",
      "min": 0,
      "definition": "A component of the method to generate the statistic.",
      "isModifier": false,
      "short": "An aspect of the statistical model",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.modelCharacteristic",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.modelCharacteristic.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.modelCharacteristic.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.modelCharacteristic.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.modelCharacteristic.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.code",
      "min": 1,
      "definition": "Description of a component of the method to generate the statistic.",
      "isModifier": false,
      "short": "Model specification",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://hl7.org/fhir/ValueSet/statistic-model-code",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "StatisticModelCode"
        } ]
      },
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.modelCharacteristic.code",
      "base": {
        "max": "1",
        "min": 1,
        "path": "Evidence.statistic.modelCharacteristic.code"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.value",
      "min": 0,
      "definition": "Further specification of the quantified value of the component of the method to generate the statistic.",
      "isModifier": false,
      "short": "Numerical value to complete model specification",
      "type": [ {
        "code": "Quantity",
        "profile": [ "http://hl7.org/fhir/StructureDefinition/SimpleQuantity" ]
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.modelCharacteristic.value",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.value"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable",
      "min": 0,
      "definition": "A variable adjusted for in the adjusted analysis.",
      "isModifier": false,
      "short": "A variable adjusted for in the adjusted analysis",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.modelCharacteristic.variable",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.variable"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.modelCharacteristic.variable.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.modelCharacteristic.variable.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.modelCharacteristic.variable.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.modelCharacteristic.variable.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.variableDefinition",
      "min": 1,
      "definition": "Description of the variable.",
      "isModifier": false,
      "short": "Description of the variable",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "http://hl7.org/fhir/StructureDefinition/Group", "http://hl7.org/fhir/StructureDefinition/EvidenceVariable" ]
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.modelCharacteristic.variable.variableDefinition",
      "base": {
        "max": "1",
        "min": 1,
        "path": "Evidence.statistic.modelCharacteristic.variable.variableDefinition"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.handling",
      "min": 0,
      "definition": "How the variable is classified for use in adjusted analysis.",
      "isModifier": false,
      "short": "continuous | dichotomous | ordinal | polychotomous",
      "type": [ {
        "code": "code"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "required",
        "valueSet": "http://hl7.org/fhir/ValueSet/variable-handling|5.0.0",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "EvidenceVariableHandling"
        } ]
      },
      "max": "1",
      "id": "Evidence.statistic:relativeEffect.modelCharacteristic.variable.handling",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.variable.handling"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.valueCategory",
      "min": 0,
      "definition": "Description for grouping of ordinal or polychotomous variables.",
      "isModifier": false,
      "short": "Description for grouping of ordinal or polychotomous variables",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.modelCharacteristic.variable.valueCategory",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.variable.valueCategory"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.valueQuantity",
      "min": 0,
      "definition": "Discrete value for grouping of ordinal or polychotomous variables.",
      "isModifier": false,
      "short": "Discrete value for grouping of ordinal or polychotomous variables",
      "type": [ {
        "code": "Quantity"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.modelCharacteristic.variable.valueQuantity",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.variable.valueQuantity"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.valueRange",
      "min": 0,
      "definition": "Range of values for grouping of ordinal or polychotomous variables.",
      "isModifier": false,
      "short": "Range of values for grouping of ordinal or polychotomous variables",
      "type": [ {
        "code": "Range"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.modelCharacteristic.variable.valueRange",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.variable.valueRange"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.attributeEstimate",
      "min": 0,
      "definition": "An attribute of the statistic used as a model characteristic.",
      "isModifier": false,
      "short": "An attribute of the statistic used as a model characteristic",
      "contentReference": "http://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate",
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:relativeEffect.modelCharacteristic.attributeEstimate",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.attributeEstimate"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic",
      "min": 0,
      "definition": "Values and parameters for a single statistic.",
      "isModifier": false,
      "short": "Values and parameters for a single statistic",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": true,
      "sliceName": "baselineRisk",
      "max": "1",
      "id": "Evidence.statistic:baselineRisk",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic:baselineRisk.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.statistic:baselineRisk.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.description",
      "min": 1,
      "definition": "A description of the content value of the statistic.",
      "isModifier": false,
      "short": "Description of content",
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.description",
      "patternMarkdown": "Baseline risk/result in the comparison group",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.description"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.note",
      "min": 0,
      "definition": "Footnotes and/or explanatory notes.",
      "isModifier": false,
      "short": "Footnotes and/or explanatory notes",
      "type": [ {
        "code": "Annotation"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:baselineRisk.note",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.note"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.statisticType",
      "min": 1,
      "definition": "Type of statistic, e.g., relative risk.",
      "isModifier": false,
      "short": "Type of statistic, e.g., relative risk",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": true,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://hl7.org/fhir/ValueSet/statistic-type",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "StatisticType"
        } ]
      },
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.statisticType",
      "patternCodeableConcept": {
        "coding": [ {
          "code": "C16726",
          "system": "http://terminology.hl7.org/CodeSystem/statistic-type",
          "display": "Incidence"
        } ]
      },
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.statisticType"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.category",
      "min": 0,
      "definition": "When the measured variable is handled categorically, the category element is used to define which category the statistic is reporting.",
      "isModifier": false,
      "short": "Associated category for categorical variable",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.category",
      "comment": "Simple strings can be used for descriptive purposes. Exact matching to EvidenceVariable.category.name for the Evidence.variableDefinition[variableRole=measuredVariable].observed=Reference(EvidenceVariable) could facilitate validation within datasets.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.category"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.quantity",
      "min": 1,
      "definition": "Statistic value.",
      "isModifier": false,
      "short": "Baseline risk of the presented evidence (intervention vs. comparator) for dichotomous outcomes",
      "type": [ {
        "code": "Quantity"
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.quantity",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.quantity"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.quantity.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "id"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.quantity.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.quantity.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "slicing": {
        "rules": "open",
        "description": "Extensions are always sliced by (at least) url",
        "discriminator": [ {
          "path": "url",
          "type": "value"
        } ]
      },
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic:baselineRisk.quantity.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.quantity.value",
      "requirements": "Precision is handled implicitly in almost all cases of measurement.",
      "min": 0,
      "definition": "The value of the measured amount. The value includes an implicit precision in the presentation of the value.",
      "isModifier": false,
      "short": "Numerical value (with implicit precision)",
      "mapping": [ {
        "map": "SN.2  / CQ - N/A",
        "identity": "v2"
      }, {
        "map": "PQ.value, CO.value, MO.value, IVL.high or IVL.low depending on the value",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "decimal"
      } ],
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.quantity.value",
      "comment": "The implicit precision in the value should always be honored. Monetary values have their own rules for handling precision (refer to standard accounting text books).",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.value"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.quantity.comparator",
      "requirements": "Need a framework for handling measures where the value is <5ug/L or >400mg/L due to the limitations of measuring methodology.",
      "min": 0,
      "definition": "How the value should be understood and represented - whether the actual value is greater or less than the stated value due to measurement issues; e.g. if the comparator is \"<\" , then the real value is < stated value.",
      "isModifier": true,
      "short": "< | <= | >= | > | ad - how to understand the value",
      "mapping": [ {
        "map": "SN.1  / CQ.1",
        "identity": "v2"
      }, {
        "map": "IVL properties",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "code"
      } ],
      "meaningWhenMissing": "If there is no comparator, then there is no modification of the value",
      "binding": {
        "strength": "required",
        "valueSet": "http://hl7.org/fhir/ValueSet/quantity-comparator|5.0.0",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "QuantityComparator"
        } ],
        "description": "How the Quantity should be understood and represented."
      },
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.quantity.comparator",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.comparator"
      },
      "isModifierReason": "This is labeled as \"Is Modifier\" because the comparator modifies the interpretation of the value significantly. If there is no comparator, then there is no modification of the value",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.quantity.unit",
      "requirements": "There are many representations for units of measure and in many contexts, particular representations are fixed and required. I.e. mcg for micrograms.",
      "min": 0,
      "definition": "A human-readable form of the unit.",
      "isModifier": false,
      "short": "Unit representation",
      "mapping": [ {
        "map": "(see OBX.6 etc.) / CQ.2",
        "identity": "v2"
      }, {
        "map": "PQ.unit",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "string"
      } ],
      "extension": [ {
        "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
        "valueBoolean": true
      }, {
        "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
        "valueBoolean": true
      } ],
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.quantity.unit",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.unit"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.quantity.system",
      "requirements": "Need to know the system that defines the coded form of the unit.",
      "min": 1,
      "definition": "The identification of the system that provides the coded form of the unit.",
      "isModifier": false,
      "short": "System that defines coded unit form",
      "mapping": [ {
        "map": "(see OBX.6 etc.) / CQ.2",
        "identity": "v2"
      }, {
        "map": "CO.codeSystem, PQ.translation.codeSystem",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "uri"
      } ],
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.quantity.system",
      "condition": [ "qty-3" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.system"
      },
      "patternUri": "http://unitsofmeasure.org",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.quantity.code",
      "requirements": "Need a computable form of the unit that is fixed across all forms. UCUM provides this for quantities, but SNOMED CT provides many units of interest.",
      "min": 1,
      "definition": "A computer processable form of the unit in some unit representation system.",
      "isModifier": false,
      "short": "Coded form of the unit",
      "mapping": [ {
        "map": "(see OBX.6 etc.) / CQ.2",
        "identity": "v2"
      }, {
        "map": "PQ.code, MO.currency, PQ.translation.code",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "code"
      } ],
      "patternCode": "1/1000",
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.quantity.code",
      "condition": [ "qty-3" ],
      "comment": "The preferred system is UCUM, but SNOMED CT can also be used (for customary units) or ISO 4217 for currency.  The context of use may additionally require a code from a particular system.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.code"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.numberOfEvents",
      "min": 0,
      "definition": "The number of events associated with the statistic, where the unit of analysis is different from numberAffected, sampleSize.knownDataCount and sampleSize.numberOfParticipants.",
      "isModifier": false,
      "short": "The number of events associated with the statistic",
      "type": [ {
        "code": "unsignedInt"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.numberOfEvents",
      "comment": "When the number of events is the statistic, use Evidence.statistic.quantity and set Evidence.statistic.type.coding.code=C25463 and Evidence.statistic.type.coding.display=Count. When the statistic is an Event Rate (where individual participants may have 2 or more events), use Evidence.statistic.numberOfEvents to record the total number of events rather than the number of participants with events.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.numberOfEvents"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.numberAffected",
      "min": 0,
      "definition": "The number of participants affected where the unit of analysis is the same as sampleSize.knownDataCount and sampleSize.numberOfParticipants.",
      "isModifier": false,
      "short": "The number of participants affected",
      "type": [ {
        "code": "unsignedInt"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.numberAffected",
      "comment": "When the number affected is the statistic, use Evidence.statistic.quantity and set Evidence.statistic.type.coding.code=C25463 and Evidence.statistic.type.coding.display=Count. When the statistic is a Proportion, use Evidence.statistic.numberAffected and enter an integer as the value. When the statistic is an Event Rate (where individual participants may have 2 or more events), use Evidence.statistic.numberAffected to record the number of participants with events rather than the total number of events.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.numberAffected"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize",
      "min": 0,
      "definition": "Number of samples in the statistic.",
      "isModifier": false,
      "short": "Number of samples in the statistic",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.sampleSize",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.sampleSize"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.sampleSize.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.sampleSize.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.sampleSize.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic:baselineRisk.sampleSize.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.sampleSize.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.statistic:baselineRisk.sampleSize.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize.description",
      "min": 0,
      "definition": "Human-readable summary of population sample size.",
      "isModifier": false,
      "short": "Textual description of sample size for statistic",
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.sampleSize.description",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.sampleSize.description"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize.note",
      "min": 0,
      "definition": "Footnote or explanatory note about the sample size.",
      "isModifier": false,
      "short": "Footnote or explanatory note about the sample size",
      "type": [ {
        "code": "Annotation"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:baselineRisk.sampleSize.note",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.sampleSize.note"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize.numberOfStudies",
      "min": 0,
      "definition": "Number of participants in the population.",
      "isModifier": false,
      "short": "Number of contributing studies",
      "type": [ {
        "code": "unsignedInt"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.sampleSize.numberOfStudies",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.sampleSize.numberOfStudies"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize.numberOfParticipants",
      "min": 0,
      "definition": "A human-readable string to clarify or explain concepts about the sample size.",
      "isModifier": false,
      "short": "Cumulative number of participants",
      "type": [ {
        "code": "unsignedInt"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.sampleSize.numberOfParticipants",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.sampleSize.numberOfParticipants"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize.knownDataCount",
      "min": 0,
      "definition": "Number of participants with known results for measured variables.",
      "isModifier": false,
      "short": "Number of participants with known results for measured variables",
      "type": [ {
        "code": "unsignedInt"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.sampleSize.knownDataCount",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.sampleSize.knownDataCount"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate",
      "min": 0,
      "definition": "A statistical attribute of the statistic such as a measure of heterogeneity.",
      "isModifier": false,
      "short": "An attribute of the Statistic",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:baselineRisk.attributeEstimate",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.attributeEstimate.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.attributeEstimate.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.attributeEstimate.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic:baselineRisk.attributeEstimate.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.attributeEstimate.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.statistic:baselineRisk.attributeEstimate.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.description",
      "min": 0,
      "definition": "Human-readable summary of the estimate.",
      "isModifier": false,
      "short": "Textual description of the attribute estimate",
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.attributeEstimate.description",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.description"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.note",
      "min": 0,
      "definition": "Footnote or explanatory note about the estimate.",
      "isModifier": false,
      "short": "Footnote or explanatory note about the estimate",
      "type": [ {
        "code": "Annotation"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:baselineRisk.attributeEstimate.note",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.note"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type",
      "min": 0,
      "definition": "The type of attribute estimate, e.g., confidence interval or p value.",
      "isModifier": false,
      "short": "The type of attribute estimate, e.g., confidence interval or p value",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://hl7.org/fhir/ValueSet/attribute-estimate-type",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "AttributeEstimateType"
        } ]
      },
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.attributeEstimate.type",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.type"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.quantity",
      "min": 0,
      "definition": "The singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure.",
      "isModifier": false,
      "short": "The singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure",
      "type": [ {
        "code": "Quantity"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.attributeEstimate.quantity",
      "comment": "Often the p value",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.quantity"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.level",
      "min": 0,
      "definition": "Use 95 for a 95% confidence interval.",
      "isModifier": false,
      "short": "Level of confidence interval, e.g., 0.95 for 95% confidence interval",
      "type": [ {
        "code": "decimal"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.attributeEstimate.level",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.level"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.range",
      "min": 0,
      "definition": "Lower bound of confidence interval.",
      "isModifier": false,
      "short": "Lower and upper bound values of the attribute estimate",
      "type": [ {
        "code": "Range"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.attributeEstimate.range",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.range"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.attributeEstimate",
      "min": 0,
      "definition": "A nested attribute estimate; which is the attribute estimate of an attribute estimate.",
      "isModifier": false,
      "short": "A nested attribute estimate; which is the attribute estimate of an attribute estimate",
      "contentReference": "http://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate",
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:baselineRisk.attributeEstimate.attributeEstimate",
      "comment": "A nested attribute estimate; which is the attribute estimate of an attribute estimate",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.attributeEstimate"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic",
      "min": 0,
      "definition": "A component of the method to generate the statistic.",
      "isModifier": false,
      "short": "An aspect of the statistical model",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:baselineRisk.modelCharacteristic",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.modelCharacteristic.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.modelCharacteristic.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic:baselineRisk.modelCharacteristic.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.statistic:baselineRisk.modelCharacteristic.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.code",
      "min": 1,
      "definition": "Description of a component of the method to generate the statistic.",
      "isModifier": false,
      "short": "Model specification",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://hl7.org/fhir/ValueSet/statistic-model-code",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "StatisticModelCode"
        } ]
      },
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.modelCharacteristic.code",
      "base": {
        "max": "1",
        "min": 1,
        "path": "Evidence.statistic.modelCharacteristic.code"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.value",
      "min": 0,
      "definition": "Further specification of the quantified value of the component of the method to generate the statistic.",
      "isModifier": false,
      "short": "Numerical value to complete model specification",
      "type": [ {
        "code": "Quantity",
        "profile": [ "http://hl7.org/fhir/StructureDefinition/SimpleQuantity" ]
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.modelCharacteristic.value",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.value"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable",
      "min": 0,
      "definition": "A variable adjusted for in the adjusted analysis.",
      "isModifier": false,
      "short": "A variable adjusted for in the adjusted analysis",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:baselineRisk.modelCharacteristic.variable",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.variable"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.modelCharacteristic.variable.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.modelCharacteristic.variable.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic:baselineRisk.modelCharacteristic.variable.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.statistic:baselineRisk.modelCharacteristic.variable.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.variableDefinition",
      "min": 1,
      "definition": "Description of the variable.",
      "isModifier": false,
      "short": "Description of the variable",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "http://hl7.org/fhir/StructureDefinition/Group", "http://hl7.org/fhir/StructureDefinition/EvidenceVariable" ]
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.modelCharacteristic.variable.variableDefinition",
      "base": {
        "max": "1",
        "min": 1,
        "path": "Evidence.statistic.modelCharacteristic.variable.variableDefinition"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.handling",
      "min": 0,
      "definition": "How the variable is classified for use in adjusted analysis.",
      "isModifier": false,
      "short": "continuous | dichotomous | ordinal | polychotomous",
      "type": [ {
        "code": "code"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "required",
        "valueSet": "http://hl7.org/fhir/ValueSet/variable-handling|5.0.0",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "EvidenceVariableHandling"
        } ]
      },
      "max": "1",
      "id": "Evidence.statistic:baselineRisk.modelCharacteristic.variable.handling",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.variable.handling"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.valueCategory",
      "min": 0,
      "definition": "Description for grouping of ordinal or polychotomous variables.",
      "isModifier": false,
      "short": "Description for grouping of ordinal or polychotomous variables",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:baselineRisk.modelCharacteristic.variable.valueCategory",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.variable.valueCategory"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.valueQuantity",
      "min": 0,
      "definition": "Discrete value for grouping of ordinal or polychotomous variables.",
      "isModifier": false,
      "short": "Discrete value for grouping of ordinal or polychotomous variables",
      "type": [ {
        "code": "Quantity"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:baselineRisk.modelCharacteristic.variable.valueQuantity",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.variable.valueQuantity"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.valueRange",
      "min": 0,
      "definition": "Range of values for grouping of ordinal or polychotomous variables.",
      "isModifier": false,
      "short": "Range of values for grouping of ordinal or polychotomous variables",
      "type": [ {
        "code": "Range"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:baselineRisk.modelCharacteristic.variable.valueRange",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.variable.valueRange"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.attributeEstimate",
      "min": 0,
      "definition": "An attribute of the statistic used as a model characteristic.",
      "isModifier": false,
      "short": "An attribute of the statistic used as a model characteristic",
      "contentReference": "http://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate",
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:baselineRisk.modelCharacteristic.attributeEstimate",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.attributeEstimate"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic",
      "min": 0,
      "definition": "Values and parameters for a single statistic.",
      "isModifier": false,
      "short": "Values and parameters for a single statistic",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": true,
      "sliceName": "meanDifference",
      "max": "1",
      "id": "Evidence.statistic:meanDifference",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic:meanDifference.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic:meanDifference.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.statistic:meanDifference.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.description",
      "min": 1,
      "definition": "A description of the content value of the statistic.",
      "isModifier": false,
      "short": "Description of content",
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:meanDifference.description",
      "patternMarkdown": "Difference intervention vs. comparator",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.description"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.note",
      "min": 0,
      "definition": "Footnotes and/or explanatory notes.",
      "isModifier": false,
      "short": "Footnotes and/or explanatory notes",
      "type": [ {
        "code": "Annotation"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:meanDifference.note",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.note"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.statisticType",
      "min": 1,
      "definition": "Type of statistic, e.g., relative risk.",
      "isModifier": false,
      "short": "Type of statistic, e.g., relative risk",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": true,
      "binding": {
        "strength": "required",
        "valueSet": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/ValueSet/vs-mean-difference-type"
      },
      "max": "1",
      "id": "Evidence.statistic:meanDifference.statisticType",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.statisticType"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.category",
      "min": 0,
      "definition": "When the measured variable is handled categorically, the category element is used to define which category the statistic is reporting.",
      "isModifier": false,
      "short": "Associated category for categorical variable",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:meanDifference.category",
      "comment": "Simple strings can be used for descriptive purposes. Exact matching to EvidenceVariable.category.name for the Evidence.variableDefinition[variableRole=measuredVariable].observed=Reference(EvidenceVariable) could facilitate validation within datasets.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.category"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.quantity",
      "min": 1,
      "definition": "Statistic value.",
      "isModifier": false,
      "short": "Difference intervention vs. comparator for continous outcomes",
      "type": [ {
        "code": "Quantity"
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Evidence.statistic:meanDifference.quantity",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.quantity"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.numberOfEvents",
      "min": 0,
      "definition": "The number of events associated with the statistic, where the unit of analysis is different from numberAffected, sampleSize.knownDataCount and sampleSize.numberOfParticipants.",
      "isModifier": false,
      "short": "The number of events associated with the statistic",
      "type": [ {
        "code": "unsignedInt"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:meanDifference.numberOfEvents",
      "comment": "When the number of events is the statistic, use Evidence.statistic.quantity and set Evidence.statistic.type.coding.code=C25463 and Evidence.statistic.type.coding.display=Count. When the statistic is an Event Rate (where individual participants may have 2 or more events), use Evidence.statistic.numberOfEvents to record the total number of events rather than the number of participants with events.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.numberOfEvents"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.numberAffected",
      "min": 0,
      "definition": "The number of participants affected where the unit of analysis is the same as sampleSize.knownDataCount and sampleSize.numberOfParticipants.",
      "isModifier": false,
      "short": "The number of participants affected",
      "type": [ {
        "code": "unsignedInt"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:meanDifference.numberAffected",
      "comment": "When the number affected is the statistic, use Evidence.statistic.quantity and set Evidence.statistic.type.coding.code=C25463 and Evidence.statistic.type.coding.display=Count. When the statistic is a Proportion, use Evidence.statistic.numberAffected and enter an integer as the value. When the statistic is an Event Rate (where individual participants may have 2 or more events), use Evidence.statistic.numberAffected to record the number of participants with events rather than the total number of events.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.numberAffected"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize",
      "min": 0,
      "definition": "Number of samples in the statistic.",
      "isModifier": false,
      "short": "Number of samples in the statistic",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:meanDifference.sampleSize",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.sampleSize"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.sampleSize.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic:meanDifference.sampleSize.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.sampleSize.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic:meanDifference.sampleSize.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.sampleSize.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.statistic:meanDifference.sampleSize.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize.description",
      "min": 0,
      "definition": "Human-readable summary of population sample size.",
      "isModifier": false,
      "short": "Textual description of sample size for statistic",
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:meanDifference.sampleSize.description",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.sampleSize.description"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize.note",
      "min": 0,
      "definition": "Footnote or explanatory note about the sample size.",
      "isModifier": false,
      "short": "Footnote or explanatory note about the sample size",
      "type": [ {
        "code": "Annotation"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:meanDifference.sampleSize.note",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.sampleSize.note"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize.numberOfStudies",
      "min": 0,
      "definition": "Number of participants in the population.",
      "isModifier": false,
      "short": "Number of contributing studies",
      "type": [ {
        "code": "unsignedInt"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:meanDifference.sampleSize.numberOfStudies",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.sampleSize.numberOfStudies"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize.numberOfParticipants",
      "min": 0,
      "definition": "A human-readable string to clarify or explain concepts about the sample size.",
      "isModifier": false,
      "short": "Cumulative number of participants",
      "type": [ {
        "code": "unsignedInt"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:meanDifference.sampleSize.numberOfParticipants",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.sampleSize.numberOfParticipants"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.sampleSize.knownDataCount",
      "min": 0,
      "definition": "Number of participants with known results for measured variables.",
      "isModifier": false,
      "short": "Number of participants with known results for measured variables",
      "type": [ {
        "code": "unsignedInt"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:meanDifference.sampleSize.knownDataCount",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.sampleSize.knownDataCount"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate",
      "min": 1,
      "definition": "A statistical attribute of the statistic such as a measure of heterogeneity.",
      "isModifier": false,
      "short": "An attribute of the Statistic",
      "slicing": {
        "rules": "open",
        "discriminator": [ {
          "path": "type",
          "type": "value"
        } ]
      },
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": true,
      "max": "*",
      "id": "Evidence.statistic:meanDifference.attributeEstimate",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.attributeEstimate.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic:meanDifference.attributeEstimate.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.attributeEstimate.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic:meanDifference.attributeEstimate.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.attributeEstimate.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.statistic:meanDifference.attributeEstimate.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.description",
      "min": 0,
      "definition": "Human-readable summary of the estimate.",
      "isModifier": false,
      "short": "Textual description of the attribute estimate",
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:meanDifference.attributeEstimate.description",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.description"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.note",
      "min": 0,
      "definition": "Footnote or explanatory note about the estimate.",
      "isModifier": false,
      "short": "Footnote or explanatory note about the estimate",
      "type": [ {
        "code": "Annotation"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:meanDifference.attributeEstimate.note",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.note"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type",
      "min": 0,
      "definition": "The type of attribute estimate, e.g., confidence interval or p value.",
      "isModifier": false,
      "short": "The type of attribute estimate, e.g., confidence interval or p value",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://hl7.org/fhir/ValueSet/attribute-estimate-type",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "AttributeEstimateType"
        } ]
      },
      "max": "1",
      "id": "Evidence.statistic:meanDifference.attributeEstimate.type",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.type"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.quantity",
      "min": 0,
      "definition": "The singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure.",
      "isModifier": false,
      "short": "The singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure",
      "type": [ {
        "code": "Quantity"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:meanDifference.attributeEstimate.quantity",
      "comment": "Often the p value",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.quantity"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.level",
      "min": 0,
      "definition": "Use 95 for a 95% confidence interval.",
      "isModifier": false,
      "short": "Level of confidence interval, e.g., 0.95 for 95% confidence interval",
      "type": [ {
        "code": "decimal"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:meanDifference.attributeEstimate.level",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.level"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.range",
      "min": 0,
      "definition": "Lower bound of confidence interval.",
      "isModifier": false,
      "short": "Lower and upper bound values of the attribute estimate",
      "type": [ {
        "code": "Range"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:meanDifference.attributeEstimate.range",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.range"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.attributeEstimate",
      "min": 0,
      "definition": "A nested attribute estimate; which is the attribute estimate of an attribute estimate.",
      "isModifier": false,
      "short": "A nested attribute estimate; which is the attribute estimate of an attribute estimate",
      "contentReference": "http://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate",
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:meanDifference.attributeEstimate.attributeEstimate",
      "comment": "A nested attribute estimate; which is the attribute estimate of an attribute estimate",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.attributeEstimate"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate",
      "min": 1,
      "definition": "A statistical attribute of the statistic such as a measure of heterogeneity.",
      "isModifier": false,
      "short": "An attribute of the Statistic",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": true,
      "sliceName": "confidenceInterval",
      "max": "1",
      "id": "Evidence.statistic:meanDifference.attributeEstimate:confidenceInterval",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.attributeEstimate.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic:meanDifference.attributeEstimate:confidenceInterval.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.attributeEstimate.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic:meanDifference.attributeEstimate:confidenceInterval.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.attributeEstimate.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.statistic:meanDifference.attributeEstimate:confidenceInterval.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.description",
      "min": 0,
      "definition": "Human-readable summary of the estimate.",
      "isModifier": false,
      "short": "Textual description of the attribute estimate",
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:meanDifference.attributeEstimate:confidenceInterval.description",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.description"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.note",
      "min": 0,
      "definition": "Footnote or explanatory note about the estimate.",
      "isModifier": false,
      "short": "Footnote or explanatory note about the estimate",
      "type": [ {
        "code": "Annotation"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:meanDifference.attributeEstimate:confidenceInterval.note",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.note"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type",
      "min": 1,
      "definition": "The type of attribute estimate, e.g., confidence interval or p value.",
      "isModifier": false,
      "short": "The type of attribute estimate, e.g., confidence interval or p value",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://hl7.org/fhir/ValueSet/attribute-estimate-type",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "AttributeEstimateType"
        } ]
      },
      "max": "1",
      "id": "Evidence.statistic:meanDifference.attributeEstimate:confidenceInterval.type",
      "patternCodeableConcept": {
        "coding": [ {
          "code": "C53324",
          "system": "http://terminology.hl7.org/CodeSystem/attribute-estimate-type",
          "display": "Confidence interval"
        } ]
      },
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.type"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.attributeEstimate.type.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "id"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic:meanDifference.attributeEstimate:confidenceInterval.type.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "slicing": {
        "rules": "open",
        "description": "Extensions are always sliced by (at least) url",
        "discriminator": [ {
          "path": "url",
          "type": "value"
        } ]
      },
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic:meanDifference.attributeEstimate:confidenceInterval.type.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type.coding",
      "requirements": "Allows for alternative encodings within a code system, and translations to other code systems.",
      "min": 0,
      "definition": "A reference to a code defined by a terminology system.",
      "isModifier": false,
      "short": "Code defined by a terminology system",
      "mapping": [ {
        "map": "C*E.1-8, C*E.10-22",
        "identity": "v2"
      }, {
        "map": "union(., ./translation)",
        "identity": "rim"
      }, {
        "map": "fhir:CodeableConcept.coding rdfs:subPropertyOf dt:CD.coding",
        "identity": "orim"
      } ],
      "type": [ {
        "code": "Coding"
      } ],
      "max": "*",
      "id": "Evidence.statistic:meanDifference.attributeEstimate:confidenceInterval.type.coding",
      "comment": "Codes may be defined very casually in enumerations, or code lists, up to very formal definitions such as SNOMED CT - see the HL7 v3 Core Principles for more information.  Ordering of codings is undefined and SHALL NOT be used to infer meaning. Generally, at most only one of the coding values will be labeled as UserSelected = true.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "CodeableConcept.coding"
      },
      "isSummary": true
    }, {
      "path": "Evidence.statistic.attributeEstimate.type.coding.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "id"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic:meanDifference.attributeEstimate:confidenceInterval.type.coding.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type.coding.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "slicing": {
        "rules": "open",
        "description": "Extensions are always sliced by (at least) url",
        "discriminator": [ {
          "path": "url",
          "type": "value"
        } ]
      },
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic:meanDifference.attributeEstimate:confidenceInterval.type.coding.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type.coding.system",
      "requirements": "Need to be unambiguous about the source of the definition of the symbol.",
      "min": 1,
      "definition": "The identification of the code system that defines the meaning of the symbol in the code.",
      "isModifier": false,
      "short": "Identity of the terminology system",
      "mapping": [ {
        "map": "C*E.3",
        "identity": "v2"
      }, {
        "map": "./codeSystem",
        "identity": "rim"
      }, {
        "map": "fhir:Coding.system rdfs:subPropertyOf dt:CDCoding.codeSystem",
        "identity": "orim"
      } ],
      "type": [ {
        "code": "uri"
      } ],
      "max": "1",
      "id": "Evidence.statistic:meanDifference.attributeEstimate:confidenceInterval.type.coding.system",
      "comment": "The URI may be an OID (urn:oid:...) or a UUID (urn:uuid:...).  OIDs and UUIDs SHALL be references to the HL7 OID registry. Otherwise, the URI should come from HL7's list of FHIR defined special URIs or it should be an absolute reference to some definition that establishes the system clearly and unambiguously.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Coding.system"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type.coding.version",
      "min": 0,
      "definition": "The version of the code system which was used when choosing this code. Note that a well-maintained code system does not need the version reported, because the meaning of codes is consistent across versions. However this cannot consistently be assured, and when the meaning is not guaranteed to be consistent, the version SHOULD be exchanged.",
      "isModifier": false,
      "short": "Version of the system - if relevant",
      "mapping": [ {
        "map": "C*E.7",
        "identity": "v2"
      }, {
        "map": "./codeSystemVersion",
        "identity": "rim"
      }, {
        "map": "fhir:Coding.version rdfs:subPropertyOf dt:CDCoding.codeSystemVersion",
        "identity": "orim"
      } ],
      "type": [ {
        "code": "string"
      } ],
      "max": "1",
      "id": "Evidence.statistic:meanDifference.attributeEstimate:confidenceInterval.type.coding.version",
      "comment": "Where the terminology does not clearly define what string should be used to identify code system versions, the recommendation is to use the date (expressed in FHIR date format) on which that version was officially published as the version date.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Coding.version"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type.coding.code",
      "requirements": "Need to refer to a particular code in the system.",
      "min": 1,
      "definition": "A symbol in syntax defined by the system. The symbol may be a predefined code or an expression in a syntax defined by the coding system (e.g. post-coordination).",
      "isModifier": false,
      "short": "Symbol in syntax defined by the system",
      "mapping": [ {
        "map": "C*E.1",
        "identity": "v2"
      }, {
        "map": "./code",
        "identity": "rim"
      }, {
        "map": "fhir:Coding.code rdfs:subPropertyOf dt:CDCoding.code",
        "identity": "orim"
      } ],
      "type": [ {
        "code": "code"
      } ],
      "max": "1",
      "id": "Evidence.statistic:meanDifference.attributeEstimate:confidenceInterval.type.coding.code",
      "condition": [ "cod-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Coding.code"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type.coding.display",
      "requirements": "Need to be able to carry a human-readable meaning of the code for readers that do not know  the system.",
      "min": 1,
      "definition": "A representation of the meaning of the code in the system, following the rules of the system.",
      "isModifier": false,
      "short": "Representation defined by the system",
      "mapping": [ {
        "map": "C*E.2 - but note this is not well followed",
        "identity": "v2"
      }, {
        "map": "CV.displayName",
        "identity": "rim"
      }, {
        "map": "fhir:Coding.display rdfs:subPropertyOf dt:CDCoding.displayName",
        "identity": "orim"
      } ],
      "type": [ {
        "code": "string"
      } ],
      "extension": [ {
        "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
        "valueBoolean": true
      } ],
      "max": "1",
      "id": "Evidence.statistic:meanDifference.attributeEstimate:confidenceInterval.type.coding.display",
      "condition": [ "cod-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Coding.display"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type.coding.userSelected",
      "requirements": "This has been identified as a clinical safety criterium - that this exact system/code pair was chosen explicitly, rather than inferred by the system based on some rules or language processing.",
      "min": 0,
      "definition": "Indicates that this coding was chosen by a user directly - e.g. off a pick list of available items (codes or displays).",
      "isModifier": false,
      "short": "If this coding was chosen directly by the user",
      "mapping": [ {
        "map": "Sometimes implied by being first",
        "identity": "v2"
      }, {
        "map": "CD.codingRationale",
        "identity": "rim"
      }, {
        "map": "fhir:Coding.userSelected fhir:mapsTo dt:CDCoding.codingRationale. fhir:Coding.userSelected fhir:hasMap fhir:Coding.userSelected.map. fhir:Coding.userSelected.map a fhir:Map;   fhir:target dt:CDCoding.codingRationale. fhir:Coding.userSelected\\#true a [     fhir:source \"true\";     fhir:target dt:CDCoding.codingRationale\\#O   ]",
        "identity": "orim"
      } ],
      "type": [ {
        "code": "boolean"
      } ],
      "max": "1",
      "id": "Evidence.statistic:meanDifference.attributeEstimate:confidenceInterval.type.coding.userSelected",
      "comment": "Amongst a set of alternatives, a directly chosen code is the most appropriate starting point for new translations. There is some ambiguity about what exactly 'directly chosen' implies, and trading partner agreement may be needed to clarify the use of this element and its consequences more completely.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Coding.userSelected"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.type.text",
      "requirements": "The codes from the terminologies do not always capture the correct meaning with all the nuances of the human using them, or sometimes there is no appropriate code at all. In these cases, the text is used to capture the full meaning of the source.",
      "min": 0,
      "definition": "A human language representation of the concept as seen/selected/uttered by the user who entered the data and/or which represents the intended meaning of the user.",
      "isModifier": false,
      "short": "Plain text representation of the concept",
      "mapping": [ {
        "map": "C*E.9. But note many systems use C*E.2 for this",
        "identity": "v2"
      }, {
        "map": "./originalText[mediaType/code=\"text/plain\"]/data",
        "identity": "rim"
      }, {
        "map": "fhir:CodeableConcept.text rdfs:subPropertyOf dt:CD.originalText",
        "identity": "orim"
      } ],
      "type": [ {
        "code": "string"
      } ],
      "extension": [ {
        "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
        "valueBoolean": true
      }, {
        "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
        "valueBoolean": true
      } ],
      "max": "1",
      "id": "Evidence.statistic:meanDifference.attributeEstimate:confidenceInterval.type.text",
      "comment": "Very often the text is the same as a displayName of one of the codings.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "CodeableConcept.text"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.quantity",
      "min": 0,
      "definition": "The singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure.",
      "isModifier": false,
      "short": "The singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure",
      "type": [ {
        "code": "Quantity"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:meanDifference.attributeEstimate:confidenceInterval.quantity",
      "comment": "Often the p value",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.quantity"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.level",
      "min": 1,
      "definition": "Use 95 for a 95% confidence interval.",
      "isModifier": false,
      "short": "Level of confidence interval, e.g., 0.95 for 95% confidence interval",
      "type": [ {
        "code": "decimal"
      } ],
      "mustSupport": true,
      "patternDecimal": 0.95,
      "max": "1",
      "id": "Evidence.statistic:meanDifference.attributeEstimate:confidenceInterval.level",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.level"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.range",
      "min": 1,
      "definition": "Relative effect 95% confidence interval.",
      "isModifier": false,
      "short": "Confidence interval of the relative effect",
      "type": [ {
        "code": "Range"
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Evidence.statistic:meanDifference.attributeEstimate:confidenceInterval.range",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.range"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.attributeEstimate.attributeEstimate",
      "min": 0,
      "definition": "A nested attribute estimate; which is the attribute estimate of an attribute estimate.",
      "isModifier": false,
      "short": "A nested attribute estimate; which is the attribute estimate of an attribute estimate",
      "contentReference": "http://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate",
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:meanDifference.attributeEstimate:confidenceInterval.attributeEstimate",
      "comment": "A nested attribute estimate; which is the attribute estimate of an attribute estimate",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.attributeEstimate.attributeEstimate"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic",
      "min": 0,
      "definition": "A component of the method to generate the statistic.",
      "isModifier": false,
      "short": "An aspect of the statistical model",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:meanDifference.modelCharacteristic",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.modelCharacteristic.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic:meanDifference.modelCharacteristic.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic:meanDifference.modelCharacteristic.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.statistic:meanDifference.modelCharacteristic.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.code",
      "min": 1,
      "definition": "Description of a component of the method to generate the statistic.",
      "isModifier": false,
      "short": "Model specification",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://hl7.org/fhir/ValueSet/statistic-model-code",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "StatisticModelCode"
        } ]
      },
      "max": "1",
      "id": "Evidence.statistic:meanDifference.modelCharacteristic.code",
      "base": {
        "max": "1",
        "min": 1,
        "path": "Evidence.statistic.modelCharacteristic.code"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.value",
      "min": 0,
      "definition": "Further specification of the quantified value of the component of the method to generate the statistic.",
      "isModifier": false,
      "short": "Numerical value to complete model specification",
      "type": [ {
        "code": "Quantity",
        "profile": [ "http://hl7.org/fhir/StructureDefinition/SimpleQuantity" ]
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:meanDifference.modelCharacteristic.value",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.value"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable",
      "min": 0,
      "definition": "A variable adjusted for in the adjusted analysis.",
      "isModifier": false,
      "short": "A variable adjusted for in the adjusted analysis",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:meanDifference.modelCharacteristic.variable",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.variable"
      },
      "isSummary": false
    }, {
      "path": "Evidence.statistic.modelCharacteristic.variable.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.statistic:meanDifference.modelCharacteristic.variable.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.statistic:meanDifference.modelCharacteristic.variable.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.statistic:meanDifference.modelCharacteristic.variable.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.variableDefinition",
      "min": 1,
      "definition": "Description of the variable.",
      "isModifier": false,
      "short": "Description of the variable",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "http://hl7.org/fhir/StructureDefinition/Group", "http://hl7.org/fhir/StructureDefinition/EvidenceVariable" ]
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.statistic:meanDifference.modelCharacteristic.variable.variableDefinition",
      "base": {
        "max": "1",
        "min": 1,
        "path": "Evidence.statistic.modelCharacteristic.variable.variableDefinition"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.handling",
      "min": 0,
      "definition": "How the variable is classified for use in adjusted analysis.",
      "isModifier": false,
      "short": "continuous | dichotomous | ordinal | polychotomous",
      "type": [ {
        "code": "code"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "required",
        "valueSet": "http://hl7.org/fhir/ValueSet/variable-handling|5.0.0",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "EvidenceVariableHandling"
        } ]
      },
      "max": "1",
      "id": "Evidence.statistic:meanDifference.modelCharacteristic.variable.handling",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.variable.handling"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.valueCategory",
      "min": 0,
      "definition": "Description for grouping of ordinal or polychotomous variables.",
      "isModifier": false,
      "short": "Description for grouping of ordinal or polychotomous variables",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:meanDifference.modelCharacteristic.variable.valueCategory",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.variable.valueCategory"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.valueQuantity",
      "min": 0,
      "definition": "Discrete value for grouping of ordinal or polychotomous variables.",
      "isModifier": false,
      "short": "Discrete value for grouping of ordinal or polychotomous variables",
      "type": [ {
        "code": "Quantity"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:meanDifference.modelCharacteristic.variable.valueQuantity",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.variable.valueQuantity"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.variable.valueRange",
      "min": 0,
      "definition": "Range of values for grouping of ordinal or polychotomous variables.",
      "isModifier": false,
      "short": "Range of values for grouping of ordinal or polychotomous variables",
      "type": [ {
        "code": "Range"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:meanDifference.modelCharacteristic.variable.valueRange",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.variable.valueRange"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.statistic.modelCharacteristic.attributeEstimate",
      "min": 0,
      "definition": "An attribute of the statistic used as a model characteristic.",
      "isModifier": false,
      "short": "An attribute of the statistic used as a model characteristic",
      "contentReference": "http://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate",
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.statistic:meanDifference.modelCharacteristic.attributeEstimate",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.statistic.modelCharacteristic.attributeEstimate"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.certainty",
      "min": 0,
      "definition": "Assessment of certainty, confidence in the estimates, or quality of the evidence.",
      "isModifier": false,
      "short": "Certainty or quality of the evidence",
      "type": [ {
        "code": "BackboneElement"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.certainty",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.certainty"
      },
      "isSummary": false
    }, {
      "path": "Evidence.certainty.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Evidence.certainty.id",
      "condition": [ "ele-1" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.certainty.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Evidence.certainty.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Evidence.certainty.modifierExtension",
      "requirements": "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](http://hl7.org/fhir/R5/extensibility.html#modifierExtension).",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "isModifier": true,
      "short": "Extensions that cannot be ignored even if unrecognized",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content", "modifiers" ],
      "max": "*",
      "id": "Evidence.certainty.modifierExtension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.certainty.description",
      "min": 0,
      "definition": "Textual description of certainty.",
      "isModifier": false,
      "short": "Textual description of certainty",
      "type": [ {
        "code": "markdown"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.certainty.description",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.certainty.description"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.certainty.note",
      "min": 0,
      "definition": "Footnotes and/or explanatory notes.",
      "isModifier": false,
      "short": "Footnotes and/or explanatory notes",
      "type": [ {
        "code": "Annotation"
      } ],
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.certainty.note",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.certainty.note"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.certainty.type",
      "min": 0,
      "definition": "Aspect of certainty being rated.",
      "isModifier": false,
      "short": "Aspect of certainty being rated",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://hl7.org/fhir/ValueSet/certainty-type",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "EvidenceCertaintyType"
        } ],
        "description": "The aspect of quality, confidence, or certainty."
      },
      "max": "1",
      "id": "Evidence.certainty.type",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.certainty.type"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.certainty.rating",
      "min": 0,
      "definition": "Assessment or judgement of the aspect.",
      "isModifier": false,
      "short": "Assessment or judgement of the aspect",
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "mustSupport": false,
      "binding": {
        "strength": "extensible",
        "valueSet": "http://hl7.org/fhir/ValueSet/certainty-rating",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "EvidenceCertaintyRating"
        } ],
        "description": "The assessment of quality, confidence, or certainty."
      },
      "max": "1",
      "id": "Evidence.certainty.rating",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.certainty.rating"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.certainty.rater",
      "min": 0,
      "definition": "Individual or group who did the rating.",
      "isModifier": false,
      "short": "Individual or group who did the rating",
      "type": [ {
        "code": "string"
      } ],
      "mustSupport": false,
      "max": "1",
      "id": "Evidence.certainty.rater",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Evidence.certainty.rater"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Evidence.certainty.subcomponent",
      "min": 0,
      "definition": "A domain or subdomain of certainty.",
      "isModifier": false,
      "short": "A domain or subdomain of certainty",
      "contentReference": "http://hl7.org/fhir/StructureDefinition/Evidence#Evidence.certainty",
      "mustSupport": false,
      "max": "*",
      "id": "Evidence.certainty.subcomponent",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Evidence.certainty.subcomponent"
      },
      "isSummary": false
    } ]
  },
  "status": "draft",
  "id": "c8225c09-ab26-4ae4-8098-08f06832a569",
  "kind": "resource",
  "url": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/study-outcome-evidence",
  "version": "0.1.0",
  "differential": {
    "element": [ {
      "id": "Evidence.variableDefinition:population",
      "path": "Evidence.variableDefinition",
      "sliceName": "population"
    }, {
      "id": "Evidence.variableDefinition:population.observed",
      "path": "Evidence.variableDefinition.observed",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/study-cohort" ]
      } ]
    }, {
      "id": "Evidence.variableDefinition:outcome",
      "path": "Evidence.variableDefinition",
      "sliceName": "outcome"
    }, {
      "id": "Evidence.variableDefinition:outcome.observed",
      "path": "Evidence.variableDefinition.observed",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/outcome-definition" ]
      } ]
    } ]
  },
  "contact": [ {
    "telecom": [ {
      "value": "https://www.netzwerk-universitaetsmedizin.de",
      "system": "url"
    } ]
  } ],
  "baseDefinition": "https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/outcome-evidence"
}