description: Beschreibt die BRCAness, also wie sehr ein Tumor ein Verhalten zeigt, welches BRCA1- oder BRCA2-Mutationen entspricht. Die BRCAness ist ein Indikator für die Wirksamkeit von PARP-Inhibitoren.
package_name: de.medizininformatikinitiative.kerndatensatz.mtb
derivation: constraint
name: MII_PR_MTB_BRCAness
type: Observation
elements:
  category: {mustSupport: true, index: 1}
  value[x]:
    elements:
      value: {mustSupport: true, index: 10}
      unit:
        pattern: {type: string, value: Score}
        type: string
        index: 11
      system:
        pattern: {type: uri, value: 'http://unitsofmeasure.org'}
        type: uri
        index: 12
      code:
        pattern: {type: code, value: '1'}
        type: code
        index: 13
  interpretation:
    binding: {strength: required, valueSet: 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/high-low-codes-vs'}
    mustSupport: true
    index: 14
  encounter: {mustSupport: true, index: 4}
  specimen: {mustSupport: true, index: 15}
  valueQuantity:
    type: Quantity
    mustSupport: true
    choiceOf: value
    index: 9
    slicing:
      slices:
        valueQuantity:
          match: {}
          schema: {type: Quantity, mustSupport: true, choiceOf: value, index: 9}
          min: 0
          max: 1
  value:
    mustSupport: true
    choices: []
    index: 6
    slicing:
      rules: open
      ordered: false
      discriminator:
      - {path: $this, type: type}
      min: null
      slices:
        valueQuantity:
          match: {}
          schema:
            mustSupport: true
            choices: [valueQuantity]
            index: 8
          min: 0
          max: 1
  component: {mustSupport: true, index: 16}
  code:
    short: BRCAness
    pattern:
      type: CodeableConcept
      value:
        coding:
        - {code: brcaness, system: 'https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker'}
    type: CodeableConcept
    index: 2
  identifier: {short: Biomarker-ID im Kontext des NGS-Befundes, mustSupport: true, index: 0}
  subject:
    type: Reference
    mustSupport: true
    refers: ['http://hl7.org/fhir/StructureDefinition/Group', 'http://hl7.org/fhir/StructureDefinition/Patient']
    index: 3
package_version: 2025.0.0-ballot
class: profile
kind: resource
url: https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-brcaness
base: https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-molekularer-biomarker
version: 2024.0.0-ballot
required: [subject]