description: RNA-Fusion
package_name: de.medizininformatikinitiative.kerndatensatz.mtb
derivation: constraint
name: MII_PR_MTB_RNA_Fusion
type: Observation
elements:
  meta:
    mustSupport: true
    index: 0
    elements:
      profile: {mustSupport: true, index: 1}
  identifier:
    short: VariantenId innerhalb des NGS-Befundes
    _short:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: VariantenId innerhalb des NGS-Befundes}
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: en}
        - {url: content, valueString: Variant ID within the NGS report}
    mustSupport: true
    index: 2
  focus:
    type: Reference
    mustSupport: true
    refers: ['https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-diagnose-primaertumor', 'https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-diagnose-primaertumor']
    index: 3
  component:
    array: true
    min: 10
    index: 4
    slicing:
      slices:
        three-prime-transcript-id:
          match: {}
          schema:
            short: 3' Transcript - Identifier
            _short:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: 3' Transkript - Identifier}
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: en}
                - {url: content, valueString: 3' Transcript - Identifier}
            mustSupport: true
            _required: true
            index: 52
            elements:
              code:
                pattern:
                  type: CodeableConcept
                  value:
                    coding:
                    - {code: three-prime-transcript-id, system: 'https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker'}
                index: 53
              value:
                choices: []
                index: 55
                slicing:
                  rules: open
                  ordered: false
                  discriminator:
                  - {path: $this, type: type}
                  min: null
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema:
                        mustSupport: true
                        choices: [valueCodeableConcept]
                        index: 57
                      min: 0
                      max: 1
              valueCodeableConcept:
                type: CodeableConcept
                mustSupport: true
                choiceOf: value
                index: 58
                slicing:
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema: {type: CodeableConcept, mustSupport: true, choiceOf: value, index: 58}
                      min: 0
                      max: 1
        allelic-read-depth:
          match: {}
          schema:
            short: Number reported reads
            _short:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: Anzahl berichteter Lesevorgaenge}
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: en}
                - {url: content, valueString: Number reported reads}
            index: 5
            elements:
              code: {mustSupport: true, index: 6}
              value:
                mustSupport: true
                choices: []
                index: 8
        three-prime-gene:
          match: {}
          schema:
            short: 3' Domain - Gene
            _short:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: 3' Domaene - Gen}
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: en}
                - {url: content, valueString: 3' Domain - Gene}
            mustSupport: true
            _required: true
            index: 45
            elements:
              code:
                pattern:
                  type: CodeableConcept
                  value:
                    coding:
                    - {code: three-prime-gene, system: 'https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker'}
                index: 46
              value:
                choices: []
                index: 48
                slicing:
                  rules: open
                  ordered: false
                  discriminator:
                  - {path: $this, type: type}
                  min: null
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema:
                        mustSupport: true
                        choices: [valueCodeableConcept]
                        index: 50
                      min: 0
                      max: 1
              valueCodeableConcept:
                type: CodeableConcept
                mustSupport: true
                choiceOf: value
                index: 51
                slicing:
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema: {type: CodeableConcept, mustSupport: true, choiceOf: value, index: 51}
                      min: 0
                      max: 1
        five-prime-transcript-id:
          match: {}
          schema:
            short: 5' Transcript - Identifier
            _short:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: 5' Transkript - Identifier}
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: en}
                - {url: content, valueString: 5' Transcript - Identifier}
            mustSupport: true
            _required: true
            index: 17
            elements:
              code:
                pattern:
                  type: CodeableConcept
                  value:
                    coding:
                    - {code: five-prime-transcript-id, system: 'https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker'}
                index: 18
              value:
                choices: []
                index: 20
                slicing:
                  rules: open
                  ordered: false
                  discriminator:
                  - {path: $this, type: type}
                  min: null
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema:
                        mustSupport: true
                        choices: [valueCodeableConcept]
                        index: 22
                      min: 0
                      max: 1
              valueCodeableConcept:
                type: CodeableConcept
                mustSupport: true
                choiceOf: value
                index: 23
                slicing:
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema: {type: CodeableConcept, mustSupport: true, choiceOf: value, index: 23}
                      min: 0
                      max: 1
        five-prime-strand:
          match: {}
          schema:
            short: 5' Strand
            _short:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: 5' Strang}
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: en}
                - {url: content, valueString: 5' Strand}
            mustSupport: true
            _required: true
            index: 38
            elements:
              code:
                pattern:
                  type: CodeableConcept
                  value:
                    coding:
                    - {code: five-prime-strand, system: 'https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker'}
                index: 39
              value:
                choices: []
                index: 41
                slicing:
                  rules: open
                  ordered: false
                  discriminator:
                  - {path: $this, type: type}
                  min: null
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema:
                        mustSupport: true
                        choices: [valueCodeableConcept]
                        index: 43
                      min: 0
                      max: 1
              valueCodeableConcept:
                type: CodeableConcept
                mustSupport: true
                choiceOf: value
                index: 44
                slicing:
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema: {type: CodeableConcept, mustSupport: true, choiceOf: value, index: 44}
                      min: 0
                      max: 1
        five-prime-gene:
          match: {}
          schema:
            short: 5' Domain - Gene
            _short:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: 5' Domaene - Gen}
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: en}
                - {url: content, valueString: 5' Domain - Gene}
            mustSupport: true
            _required: true
            index: 10
            elements:
              code:
                pattern:
                  type: CodeableConcept
                  value:
                    coding:
                    - {code: five-prime-gene, system: 'https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker'}
                index: 11
              value:
                choices: []
                index: 13
                slicing:
                  rules: open
                  ordered: false
                  discriminator:
                  - {path: $this, type: type}
                  min: null
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema:
                        mustSupport: true
                        choices: [valueCodeableConcept]
                        index: 15
                      min: 0
                      max: 1
              valueCodeableConcept:
                type: CodeableConcept
                mustSupport: true
                choiceOf: value
                index: 16
                slicing:
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema: {type: CodeableConcept, mustSupport: true, choiceOf: value, index: 16}
                      min: 0
                      max: 1
        variation-code:
          match: {}
          schema:
            short: Variant database ID (e.g. COSMIC)
            _short:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: Varianten-Datenbank-ID (z.B. COSMIC)}
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: en}
                - {url: content, valueString: Variant database ID (e.g. COSMIC)}
            index: 9
        five-prime-position:
          match: {}
          schema:
            short: 5' Domain - Position
            _short:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: 5' Domaene - Position}
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: en}
                - {url: content, valueString: 5' Domain - Position}
            mustSupport: true
            _required: true
            index: 31
            elements:
              code:
                pattern:
                  type: CodeableConcept
                  value:
                    coding:
                    - {code: five-prime-position, system: 'https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker'}
                index: 32
              value:
                choices: []
                index: 34
                slicing:
                  rules: open
                  ordered: false
                  discriminator:
                  - {path: $this, type: type}
                  min: null
                  slices:
                    valueRange:
                      match: {}
                      schema:
                        mustSupport: true
                        choices: [valueRange]
                        index: 36
                      min: 0
                      max: 1
              valueRange:
                type: Range
                mustSupport: true
                choiceOf: value
                index: 37
                slicing:
                  slices:
                    valueRange:
                      match: {}
                      schema: {type: Range, mustSupport: true, choiceOf: value, index: 37}
                      min: 0
                      max: 1
        three-prime-strand:
          match: {}
          schema:
            short: 3' Strand
            _short:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: 3' Strang}
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: en}
                - {url: content, valueString: 3' Strand}
            mustSupport: true
            _required: true
            index: 73
            elements:
              code:
                pattern:
                  type: CodeableConcept
                  value:
                    coding:
                    - {code: three-prime-strand, system: 'https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker'}
                index: 74
              value:
                choices: []
                index: 76
                slicing:
                  rules: open
                  ordered: false
                  discriminator:
                  - {path: $this, type: type}
                  min: null
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema:
                        mustSupport: true
                        choices: [valueCodeableConcept]
                        index: 78
                      min: 0
                      max: 1
              valueCodeableConcept:
                type: CodeableConcept
                mustSupport: true
                choiceOf: value
                index: 79
                slicing:
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema: {type: CodeableConcept, mustSupport: true, choiceOf: value, index: 79}
                      min: 0
                      max: 1
        three-prime-position:
          match: {}
          schema:
            short: 3' Domain - Position
            _short:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: 3' Domaene - Position}
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: en}
                - {url: content, valueString: 3' Domain - Position}
            mustSupport: true
            _required: true
            index: 66
            elements:
              code:
                pattern:
                  type: CodeableConcept
                  value:
                    coding:
                    - {code: three-prime-position, system: 'https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker'}
                index: 67
              value:
                choices: []
                index: 69
                slicing:
                  rules: open
                  ordered: false
                  discriminator:
                  - {path: $this, type: type}
                  min: null
                  slices:
                    valueRange:
                      match: {}
                      schema:
                        mustSupport: true
                        choices: [valueRange]
                        index: 71
                      min: 0
                      max: 1
              valueRange:
                type: Range
                mustSupport: true
                choiceOf: value
                index: 72
                slicing:
                  slices:
                    valueRange:
                      match: {}
                      schema: {type: Range, mustSupport: true, choiceOf: value, index: 72}
                      min: 0
                      max: 1
        five-prime-exon-id:
          match: {}
          schema:
            short: 5' Exon - Identifier
            _short:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: 5' Exon - Identifier}
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: en}
                - {url: content, valueString: 5' Exon - Identifier}
            mustSupport: true
            _required: true
            index: 24
            elements:
              code:
                pattern:
                  type: CodeableConcept
                  value:
                    coding:
                    - {code: five-prime-exon-id, system: 'https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker'}
                index: 25
              value:
                choices: []
                index: 27
                slicing:
                  rules: open
                  ordered: false
                  discriminator:
                  - {path: $this, type: type}
                  min: null
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema:
                        mustSupport: true
                        choices: [valueCodeableConcept]
                        index: 29
                      min: 0
                      max: 1
              valueCodeableConcept:
                type: CodeableConcept
                mustSupport: true
                choiceOf: value
                index: 30
                slicing:
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema: {type: CodeableConcept, mustSupport: true, choiceOf: value, index: 30}
                      min: 0
                      max: 1
        three-prime-exon-id:
          match: {}
          schema:
            short: 3' Exon - Identifier
            _short:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: 3' Exon - Identifier}
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: en}
                - {url: content, valueString: 3' Exon - Identifier}
            mustSupport: true
            _required: true
            index: 59
            elements:
              code:
                pattern:
                  type: CodeableConcept
                  value:
                    coding:
                    - {code: three-prime-exon-id, system: 'https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker'}
                index: 60
              value:
                choices: []
                index: 62
                slicing:
                  rules: open
                  ordered: false
                  discriminator:
                  - {path: $this, type: type}
                  min: null
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema:
                        mustSupport: true
                        choices: [valueCodeableConcept]
                        index: 64
                      min: 0
                      max: 1
              valueCodeableConcept:
                type: CodeableConcept
                mustSupport: true
                choiceOf: value
                index: 65
                slicing:
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema: {type: CodeableConcept, mustSupport: true, choiceOf: value, index: 65}
                      min: 0
                      max: 1
package_version: 2026.0.1
class: profile
kind: resource
url: https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-rna-fusion
base: https://www.medizininformatik-initiative.de/fhir/ext/modul-molgen/StructureDefinition/variante
version: 2026.0.1