{
  "description": "0.4% incidence of fatal intracranial hemorrhage within 7 days without alteplase in patients with acute ischemic stroke",
  "_filename": "Evidence-example-stroke-no-alteplase-fatalICH.json",
  "package_name": "hl7.fhir.r4b.examples",
  "statistic": [ {
    "quantity": {
      "value": 0.00386298627
    },
    "sampleSize": {
      "numberOfStudies": 9,
      "numberOfParticipants": 3365
    },
    "statisticType": {
      "coding": [ {
        "code": "C44256",
        "system": "http://terminology.hl7.org/CodeSystem/statistic-type",
        "display": "Proportion"
      } ]
    },
    "numberOfEvents": 13
  } ],
  "date": null,
  "publisher": null,
  "name": null,
  "useContext": [ {
    "code": {
      "code": "focus",
      "system": "http://terminology.hl7.org/CodeSystem/usage-context-type"
    },
    "valueCodeableConcept": {
      "text": "Stroke"
    }
  }, {
    "code": {
      "code": "1386000",
      "system": "http://snomed.info/sct",
      "display": "Intracranial hemorrhage"
    },
    "valueRange": {
      "low": {
        "unit": "d",
        "value": 0
      },
      "high": {
        "unit": "d",
        "value": 7
      }
    }
  } ],
  "studyType": {
    "coding": [ {
      "code": "RCT",
      "system": "http://terminology.hl7.org/CodeSystem/study-type",
      "display": "randomized trial"
    } ]
  },
  "type": null,
  "experimental": null,
  "resourceType": "Evidence",
  "variableDefinition": [ {
    "intended": {
      "type": "Group",
      "display": "adults with acute ischemic stroke",
      "reference": "Group/AcuteIschemicStroke"
    },
    "observed": {
      "type": "Group",
      "display": "adults with acute ischemic stroke",
      "reference": "Group/AcuteIschemicStroke"
    },
    "variableRole": {
      "coding": [ {
        "code": "population",
        "system": "http://terminology.hl7.org/CodeSystem/variable-role",
        "display": "population"
      } ]
    }
  }, {
    "intended": {
      "type": "Group",
      "display": "adults with acute ischemic stroke treated without alteplase",
      "reference": "Group/AcuteIschemicStrokeTreatedWithoutAlteplase"
    },
    "observed": {
      "type": "Group",
      "display": "Emberson 2014 IPD-MA No Alteplase Cohort",
      "reference": "Group/Emberson-2014-IPD-MA-No-Alteplase-Cohort"
    },
    "variableRole": {
      "coding": [ {
        "code": "population",
        "system": "http://terminology.hl7.org/CodeSystem/variable-role",
        "display": "population"
      } ]
    }
  }, {
    "intended": {
      "type": "EvidenceVariable",
      "display": "fatal ICH",
      "reference": "EvidenceVariable/example-fatal-ICH-in-7-days"
    },
    "observed": {
      "type": "EvidenceVariable",
      "display": "fatal ICH",
      "reference": "EvidenceVariable/example-fatal-ICH-in-7-days"
    },
    "variableRole": {
      "coding": [ {
        "code": "measuredVariable",
        "system": "http://terminology.hl7.org/CodeSystem/variable-role",
        "display": "measured variable"
      } ]
    }
  } ],
  "title": "Risk of fatal ICH without alteplase for stroke",
  "package_version": "4.3.0",
  "synthesisType": {
    "coding": [ {
      "code": "IPD-MA",
      "system": "http://terminology.hl7.org/CodeSystem/synthesis-type",
      "display": "individual patient data meta-analysis"
    } ]
  },
  "status": "draft",
  "id": "ac2544f3-eb1c-4cf1-8c25-0da79954346d",
  "kind": null,
  "url": "http://hl7.org/fhir/Evidence/example-stroke-no-alteplase-fatalICH",
  "version": null,
  "relatedArtifact": [ {
    "url": "https://doi.org/10.1016/S0140-6736(14)60584-5",
    "type": "citation",
    "label": "Emberson 2014",
    "display": "Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials.",
    "citation": "Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, et al;Stroke Thrombolysis Trialists' Collaborative Group. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014 Nov 29;384(9958):1929-35 PMID 25106063"
  } ]
}