{
  "description": "Guidelines for reporting of clinical genomics results using HL7 FHIR",
  "_filename": "ImplementationGuide-genomics-reporting.json",
  "package_name": "hl7.fhir.uv.genomics-reporting",
  "definition": {
    "page": {
      "page": [ {
        "page": [ {
          "title": "Genomics Primer",
          "nameUrl": "background.html",
          "generation": "html"
        }, {
          "title": "General Genomic Reporting",
          "nameUrl": "general.html",
          "generation": "html"
        }, {
          "title": "Sequenced Variants",
          "nameUrl": "sequencing.html",
          "generation": "html"
        }, {
          "title": "Cytogenomic Reporting",
          "nameUrl": "cytogenomics.html",
          "generation": "html"
        }, {
          "title": "Pharmacogenomic Reporting",
          "nameUrl": "pharmacogenomics.html",
          "generation": "html"
        }, {
          "title": "Somatic Genomic Reporting",
          "nameUrl": "somatics.html",
          "generation": "html"
        }, {
          "title": "Genomic Profiling for Transplantation",
          "nameUrl": "transplants.html",
          "generation": "html"
        }, {
          "title": "Conversion from STU3",
          "nameUrl": "conversion.html",
          "generation": "html"
        }, {
          "title": "Appendix A: Relation to v2 reporting",
          "nameUrl": "v2.html",
          "generation": "html"
        }, {
          "title": "Appendix B: Clinical Genomic Apps",
          "nameUrl": "cgapps.html",
          "generation": "html"
        }, {
          "title": "Appendix C: Querying Genomics Information",
          "nameUrl": "domain.html",
          "generation": "html"
        } ],
        "title": "CG IG Home Page",
        "nameUrl": "index.html",
        "generation": "html"
      }, {
        "page": [ {
          "title": "Base observation common properties",
          "nameUrl": "obs-base.html",
          "generation": "generated"
        }, {
          "title": "CG Diagnostic Report",
          "nameUrl": "diagnosticreport.html",
          "generation": "generated"
        }, {
          "title": "CG Specimen",
          "nameUrl": "specimen.html",
          "generation": "generated"
        }, {
          "title": "Recomended Followup",
          "nameUrl": "task-rec-followup.html",
          "generation": "generated"
        }, {
          "title": "Order for Genetics Test",
          "nameUrl": "servicerequest.html",
          "generation": "generated"
        }, {
          "title": "Genetic Panel",
          "nameUrl": "obs-gen-panel.html",
          "generation": "generated"
        }, {
          "title": "Genetic analysis overall interpretation",
          "nameUrl": "obs-overall.html",
          "generation": "generated"
        }, {
          "title": "Deletion-duplication overall interpretation",
          "nameUrl": "obs-deletion-dup.html",
          "generation": "generated"
        }, {
          "title": "Chromosome analysis overall interpretation",
          "nameUrl": "obs-chrom-overall.html",
          "generation": "generated"
        }, {
          "title": "Descriptive Genetic Finding",
          "nameUrl": "obs-desc-gen-finding.html",
          "generation": "generated"
        }, {
          "title": "Computable Genetic Finding",
          "nameUrl": "obs-comp-gen-finding.html",
          "generation": "generated"
        }, {
          "title": "Haplotype",
          "nameUrl": "obs-haplotype.html",
          "generation": "generated"
        }, {
          "title": "Genotype",
          "nameUrl": "obs-genotype.html",
          "generation": "generated"
        }, {
          "title": "Cytogenic Notation",
          "nameUrl": "obs-cytogenic-not.html",
          "generation": "generated"
        }, {
          "title": "Complex Variant",
          "nameUrl": "obs-complex-variant.html",
          "generation": "generated"
        }, {
          "title": "Described Variant (Discrete or Structural)",
          "nameUrl": "obs-described-variant.html",
          "generation": "generated"
        }, {
          "title": "Definitional Sequence",
          "nameUrl": "sequence.html",
          "generation": "generated"
        }, {
          "title": "Sequence Configuration",
          "nameUrl": "obs-sequence-config.html",
          "generation": "generated"
        }, {
          "title": "Genetic Impact",
          "nameUrl": "obs-impact.html",
          "generation": "generated"
        }, {
          "title": "Inheritable Disease Pathology",
          "nameUrl": "obs-inh-dis-path.html",
          "generation": "generated"
        }, {
          "title": "Chromosome analysis G-banding panel",
          "nameUrl": "obs-chrom-g-band.html",
          "generation": "generated"
        }, {
          "title": "Chromosome Analysis FISH panel",
          "nameUrl": "obs-chrom-fish.html",
          "generation": "generated"
        }, {
          "title": "Chromosome copy number change panel",
          "nameUrl": "obs-copy-num-chg.html",
          "generation": "generated"
        }, {
          "title": "Device Micro-array Platform",
          "nameUrl": "device-micro-plat.html",
          "generation": "generated"
        }, {
          "title": "DeviceComponent Fish Probe",
          "nameUrl": "devicecomp-fish-probe.html",
          "generation": "generated"
        }, {
          "title": "Genetic Medication Impact",
          "nameUrl": "obs-med-impact.html",
          "generation": "generated"
        }, {
          "title": "Genotype medication metabolism impact",
          "nameUrl": "obs-metabolism.html",
          "generation": "generated"
        }, {
          "title": "Genotype medication efficacy impact",
          "nameUrl": "obs-efficacy.html",
          "generation": "generated"
        }, {
          "title": "High Risk Allele",
          "nameUrl": "obs-high-risk.html",
          "generation": "generated"
        }, {
          "title": "Medication Adjustment Proposal",
          "nameUrl": "task-med-chg.html",
          "generation": "generated"
        }, {
          "title": "Current Medication",
          "nameUrl": "medicationstatement.html",
          "generation": "generated"
        }, {
          "title": "Somatic Impact",
          "nameUrl": "obs-som-impact.html",
          "generation": "generated"
        }, {
          "title": "Somatic Diagnostic Impact",
          "nameUrl": "obs-som-diagnostic.html",
          "generation": "generated"
        }, {
          "title": "Somatic Prognostic Impact",
          "nameUrl": "obs-som-prognostic.html",
          "generation": "generated"
        }, {
          "title": "Somatic Predictive Impact",
          "nameUrl": "obs-som-predictive.html",
          "generation": "generated"
        }, {
          "title": "Related Artifact",
          "nameUrl": "dr-relatedArtifact.html",
          "generation": "generated"
        }, {
          "title": "Recommended action",
          "nameUrl": "dr-recommendedAction.html",
          "generation": "generated"
        }, {
          "title": "Supporting Information",
          "nameUrl": "dr-supportingInfo.html",
          "generation": "generated"
        }, {
          "title": "Focus",
          "nameUrl": "obs-focus.html",
          "generation": "generated"
        }, {
          "title": "Recommended action",
          "nameUrl": "obs-recommendedAction.html",
          "generation": "generated"
        }, {
          "title": "Unsolicited?",
          "nameUrl": "obs-unsolicited.html",
          "generation": "generated"
        }, {
          "title": "Manufacturer",
          "nameUrl": "device-comp-manufacturer.html",
          "generation": "generated"
        }, {
          "title": "CG Test",
          "nameUrl": "diagnosticreport-cgexample.html",
          "generation": "generated"
        }, {
          "title": "PGx Example",
          "nameUrl": "diagnosticreport-pgxexample.html",
          "generation": "generated"
        }, {
          "title": "HLA Example",
          "nameUrl": "CG-IG-HLA-FullBundle-01.html",
          "generation": "generated"
        } ],
        "title": "Artifact List",
        "nameUrl": "artifacts.html",
        "generation": "html"
      }, {
        "title": "HL7 Domain Analysis Use Cases",
        "nameUrl": "usecases.html",
        "generation": "html"
      } ],
      "title": "Table of Contents",
      "nameUrl": "toc.html",
      "generation": "html"
    },
    "package": [ {
      "id": "general",
      "name": "General Profiles",
      "description": "General constraints on FHIR resources to be adhered to as part of the CG implementation guide that apply regardless of what area(s) of genomics are of interest"
    }, {
      "id": "somatics",
      "name": "Somatics",
      "description": "Profiles related to the reporting of somatic genetic issues"
    }, {
      "id": "pharmacogenomics",
      "name": "Pharmacogenomics",
      "description": "Profiles for reports relating to genetic impact on medication use and effectiveness"
    }, {
      "id": "cytogenomics",
      "name": "Cytogenomics",
      "description": "Profiles for reporting cytogenic results"
    }, {
      "id": "extensions",
      "name": "Extensions",
      "description": "Extensions defined as part of the CG implementation guide"
    }, {
      "id": "examples",
      "name": "Example(s)",
      "description": "Example(s) showing the use of the CG profiles"
    }, {
      "id": "device-profile-spreadsheet.xml",
      "name": "CG Device"
    }, {
      "id": "devicecomponent-profile-spreadsheet.xml",
      "name": "CG Device Component"
    }, {
      "id": "diagnosticreport-profile-spreadsheet.xml",
      "name": "CG Diagnostic Report"
    }, {
      "id": "medicationstatement-profile-spreadsheet.xml",
      "name": "CG Medication Statement"
    }, {
      "id": "observation-profile-spreadsheet.xml",
      "name": "CG Observations"
    }, {
      "id": "sequence-profile-spreadsheet.xml",
      "name": "CG Sequence"
    }, {
      "id": "servicerequest-profile-spreadsheet.xml",
      "name": "CG Service Request"
    }, {
      "id": "specimen-profile-spreadsheet.xml",
      "name": "CG Specimen"
    }, {
      "id": "task-profile-spreadsheet.xml",
      "name": "CG Task profiles"
    } ],
    "resource": [ {
      "name": "CG Test",
      "extension": [ {
        "url": "http://hl7.org/fhir/StructureDefinition/implementationguide-page",
        "valueUri": "diagnosticreport-cgexample.html"
      } ],
      "reference": {
        "reference": "Bundle/diagnosticreport-cgexample"
      },
      "description": "Test instance showing data from the CG v2 spec",
      "exampleCanonical": "StructureDefinition/diagnosticreport"
    }, {
      "name": "PGx Example",
      "extension": [ {
        "url": "http://hl7.org/fhir/StructureDefinition/implementationguide-page",
        "valueUri": "diagnosticreport-pgxexample.html"
      } ],
      "reference": {
        "reference": "Bundle/diagnosticreport-pgxexample"
      },
      "description": "Pharmacogenomic Report Example instances",
      "exampleCanonical": "StructureDefinition/diagnosticreport"
    }, {
      "name": "HLA Example",
      "extension": [ {
        "url": "http://hl7.org/fhir/StructureDefinition/implementationguide-page",
        "valueUri": "CG-IG-HLA-FullBundle-01.html"
      } ],
      "reference": {
        "reference": "Bundle/CG-IG-HLA-FullBundle-01"
      },
      "description": "HLA Typing Example",
      "exampleCanonical": "StructureDefinition/diagnosticreport"
    }, {
      "name": "Device Microarray Platform",
      "package": "device-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/device-micro-plat"
      }
    }, {
      "name": "Manufacturer",
      "package": "devicecomponent-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/device-comp-manufacturer"
      }
    }, {
      "name": "DeviceComponent Fish Probe",
      "package": "devicecomponent-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/devicecomp-fish-probe"
      }
    }, {
      "name": "Supporting Information",
      "package": "diagnosticreport-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/dr-supportingInfo"
      }
    }, {
      "name": "Recommended Action",
      "package": "diagnosticreport-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/dr-recommendedAction"
      }
    }, {
      "name": "Related Artifact",
      "package": "diagnosticreport-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/dr-relatedArtifact"
      }
    }, {
      "name": "Genetics Diagnostic Report",
      "package": "diagnosticreport-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/diagnosticreport"
      }
    }, {
      "name": "Current Medication",
      "package": "medicationstatement-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/medicationstatement"
      }
    }, {
      "name": "GeneticCoordinateSystem",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "ValueSet/genetic-coordinate-system"
      }
    }, {
      "name": "GeneticCoordinateSystem",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "CodeSystem/genetic-coordinate-system"
      }
    }, {
      "name": "Focus",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-focus"
      }
    }, {
      "name": "Recommended Action",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-recommendedAction"
      }
    }, {
      "name": "Unsolicited?",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-unsolicited"
      }
    }, {
      "name": "Genetic Observation Common Properties",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-base"
      }
    }, {
      "name": "Genomics Panel",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-gen-panel"
      }
    }, {
      "name": "Genetic analysis overall interpretation",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-overall"
      }
    }, {
      "name": "Deletion-duplication overall interpretation",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-deletion-dup"
      }
    }, {
      "name": "Chromosome analysis overall interpretation",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-chrom-overall"
      }
    }, {
      "name": "Computable Genetic Finding",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-comp-gen-finding"
      }
    }, {
      "name": "Descriptive Genetic Finding",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-desc-gen-finding"
      }
    }, {
      "name": "Genotype",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-genotype"
      }
    }, {
      "name": "Haplotype",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-haplotype"
      }
    }, {
      "name": "Complex variation",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-complex-variant"
      }
    }, {
      "name": "Described Variant (Discrete or Structural)",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-described-variant"
      }
    }, {
      "name": "Cytogenic Notation",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-cytogenic-not"
      }
    }, {
      "name": "Sequence Configuration",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-sequence-config"
      }
    }, {
      "name": "Medication Impact",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-impact"
      }
    }, {
      "name": "Inherited Disease Pathogenicity",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-inh-dis-path"
      }
    }, {
      "name": "Medication Impact",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-med-impact"
      }
    }, {
      "name": "Genotype medication metabolism impact",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-metabolism"
      }
    }, {
      "name": "Genotype medication efficacy impact",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-efficacy"
      }
    }, {
      "name": "High Risk Allele",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-high-risk"
      }
    }, {
      "name": "Somatic Impact",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-som-impact"
      }
    }, {
      "name": "Somatic Diagnostic Impact",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-som-diagnostic"
      }
    }, {
      "name": "Somatic Prognostic Impact",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-som-prognostic"
      }
    }, {
      "name": "Somatic Predictive Impact",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-som-predictive"
      }
    }, {
      "name": "Chromosome analysis G-banding panel",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-chrom-g-band"
      }
    }, {
      "name": "Chromosome Analysis FISH panel",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-chrom-fish"
      }
    }, {
      "name": "Chromosome copy number change panel",
      "package": "observation-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/obs-copy-num-chg"
      }
    }, {
      "name": "Definitional Sequence",
      "package": "sequence-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/sequence"
      }
    }, {
      "name": "Request for Genetic Test",
      "package": "servicerequest-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/servicerequest"
      }
    }, {
      "name": "Specimen",
      "package": "specimen-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/specimen"
      }
    }, {
      "name": "Medication Usage Implications",
      "package": "task-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/task-med-chg"
      }
    }, {
      "name": "Recommended Followup",
      "package": "task-profile-spreadsheet.xml",
      "reference": {
        "reference": "StructureDefinition/task-rec-followup"
      }
    } ]
  },
  "date": null,
  "publisher": "HL7 International Clinical Genomics Work Group",
  "fhirVersion": "3.3.0",
  "license": "CC0-1.0",
  "jurisdiction": [ {
    "coding": [ {
      "code": "001",
      "system": "http://unstats.un.org/unsd/methods/m49/m49.htm"
    } ]
  } ],
  "name": "Clinical Genomics Reporting",
  "type": null,
  "experimental": "false",
  "manifest": {
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      "name": "medicationstatement.xml.html"
    }, {
      "name": "obs-genotype.json.html"
    }, {
      "name": "obs-sequence-config.profile.xml.html"
    }, {
      "name": "obs-desc-gen-finding.html"
    }, {
      "name": "obs-metabolism.json.html"
    }, {
      "name": "obs-deletion-dup.profile.xml.html"
    }, {
      "name": "obs-described-variant.json.html"
    }, {
      "name": "device-micro-plat.profile.json.html"
    }, {
      "name": "obs-copy-num-chg.profile.json.html"
    }, {
      "name": "task-rec-followup.profile.xml.html"
    }, {
      "name": "medicationstatement.profile.json.html"
    }, {
      "name": "obs-complex-variant-examples.html"
    }, {
      "name": "obs-med-impact.profile.xml.html"
    }, {
      "name": "dr-supportingInfo-mappings.html"
    }, {
      "name": "obs-base-definitions.html"
    }, {
      "name": "obs-med-impact.json.html"
    }, {
      "name": "obs-som-prognostic.html"
    }, {
      "name": "obs-overall-examples.html"
    }, {
      "name": "CG-IG-HLA-FullBundle-01.json.html"
    }, {
      "name": "obs-copy-num-chg.ttl.html"
    }, {
      "name": "obs-chrom-overall-examples.html"
    }, {
      "name": "diagnosticreport-examples.html"
    }, {
      "name": "obs-recommendedAction.profile.json.html"
    }, {
      "name": "obs-high-risk.profile.ttl.html"
    }, {
      "name": "obs-inh-dis-path-mappings.html"
    }, {
      "name": "diagnosticreport.profile.xml.html"
    }, {
      "name": "obs-chrom-fish.html"
    }, {
      "name": "obs-base.ttl.html"
    }, {
      "name": "obs-som-prognostic.profile.ttl.html"
    }, {
      "name": "transplants.html"
    }, {
      "name": "obs-chrom-fish-examples.html"
    }, {
      "name": "obs-chrom-fish.profile.ttl.html"
    }, {
      "name": "servicerequest-mappings.html"
    }, {
      "name": "sequencing.html"
    }, {
      "name": "dr-recommendedAction.json.html"
    }, {
      "name": "obs-genotype-definitions.html"
    }, {
      "name": "dr-supportingInfo.json.html"
    }, {
      "name": "obs-focus.xml.html"
    }, {
      "name": "obs-metabolism.profile.json.html"
    }, {
      "name": "obs-cytogenic-not.html"
    }, {
      "name": "obs-copy-num-chg.xml.html"
    }, {
      "name": "obs-chrom-overall.html"
    }, {
      "name": "obs-efficacy.ttl.html"
    }, {
      "name": "obs-haplotype.json.html"
    }, {
      "name": "obs-cytogenic-not-mappings.html"
    }, {
      "name": "obs-focus.html"
    }, {
      "name": "obs-impact-definitions.html"
    }, {
      "name": "obs-chrom-fish.ttl.html"
    }, {
      "name": "obs-som-predictive.html"
    }, {
      "name": "obs-haplotype-definitions.html"
    }, {
      "name": "obs-unsolicited.json.html"
    }, {
      "name": "obs-gen-panel.profile.ttl.html"
    }, {
      "name": "task-med-chg-mappings.html"
    }, {
      "name": "obs-chrom-fish.xml.html"
    }, {
      "name": "medicationstatement.json.html"
    }, {
      "name": "obs-described-variant.html"
    }, {
      "name": "obs-comp-gen-finding-mappings.html"
    }, {
      "name": "obs-genotype.ttl.html"
    }, {
      "name": "obs-sequence-config.profile.json.html"
    }, {
      "name": "dr-supportingInfo.html"
    }, {
      "name": "obs-complex-variant.profile.xml.html"
    }, {
      "name": "obs-som-prognostic.profile.xml.html"
    }, {
      "name": "obs-som-prognostic-mappings.html"
    }, {
      "name": "device-comp-manufacturer-definitions.html"
    }, {
      "name": "task-rec-followup.json.html"
    }, {
      "name": "medicationstatement-mappings.html"
    }, {
      "name": "obs-chrom-fish.profile.xml.html"
    }, {
      "name": "obs-deletion-dup.json.html"
    }, {
      "name": "obs-overall-mappings.html"
    }, {
      "name": "obs-chrom-overall-definitions.html"
    }, {
      "name": "obs-high-risk.profile.xml.html"
    }, {
      "name": "obs-gen-panel.profile.xml.html"
    }, {
      "name": "obs-som-diagnostic.profile.xml.html"
    }, {
      "name": "obs-efficacy.html"
    }, {
      "name": "dr-supportingInfo.profile.json.html"
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