{
  "description": "This (experimental) code system provides for a draft categorization of biomarkers along several axes. Based on ballot feedback, the committee anticipates significant revisions.",
  "_filename": "CodeSystem-molecular-biomarker-ontology-cs.json",
  "package_name": "hl7.fhir.uv.genomics-reporting",
  "date": "2024-12-12T20:43:36+00:00",
  "publisher": "HL7 International / Clinical Genomics",
  "jurisdiction": [ {
    "coding": [ {
      "code": "001",
      "system": "http://unstats.un.org/unsd/methods/m49/m49.htm",
      "display": "World"
    } ]
  } ],
  "content": "complete",
  "name": "MolecularBiomarkerOntologyCS",
  "type": null,
  "experimental": "true",
  "resourceType": "CodeSystem",
  "title": "Molecular Biomarker Ontology Codes",
  "package_version": "3.0.0",
  "extension": [ {
    "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg",
    "valueCode": "cg"
  } ],
  "status": "active",
  "hierarchyMeaning": "is-a",
  "id": "a32a36d6-9a66-4405-9404-9c2a7dc1ab0a",
  "kind": null,
  "count": 17,
  "url": "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/molecular-biomarker-ontology-cs",
  "concept": [ {
    "code": "_physiologyBiomarkerCategory",
    "concept": [ {
      "code": "antibody",
      "display": "antibody category",
      "definition": "Molecular biomarker physiologic role is an antibody."
    }, {
      "code": "antgen",
      "display": "antigen category",
      "definition": "Molecular biomarker physiologic role is an antigen."
    }, {
      "code": "cellReceptor",
      "display": "cell receptor category",
      "definition": "Molecular biomarker physiologic role is a cell receptor."
    }, {
      "code": "cellReceptorLigand",
      "display": "cell receptor ligand category",
      "definition": "Molecular biomarker physiologic role is a cell receptor ligand."
    } ],
    "display": "Molecular biomarker physiologic role category",
    "definition": "A category based on the normal bodily function of the biomarker."
  }, {
    "code": "_moleculeTypeBiomarkerCategory",
    "concept": [ {
      "code": "carbohydrate",
      "display": "carbohydrate category",
      "definition": "Molecular biomarker molecule type is a carbohydrate."
    }, {
      "code": "lipid",
      "display": "lipid category",
      "definition": "Molecular biomarker molecule type is a lipid."
    }, {
      "code": "nucleicAcid",
      "display": "nucleic acid category",
      "definition": "Molecular biomarker molecule type is a nucleic acid."
    }, {
      "code": "protein",
      "display": "protein category",
      "definition": "Molecular biomarker molecule type is a protein. Includes single or multi-subunit proteins with or without post-translational modifications."
    } ],
    "display": "Molecular biomarker molecular type category",
    "definition": "A category based on the type of biomarker molecule."
  }, {
    "code": "_methodBiomarkerCategory",
    "concept": [ {
      "code": "enzymeAssay",
      "display": "enzyme assay category",
      "definition": "Molecular biomarker method is enzyme assay."
    }, {
      "code": "flowCytometry",
      "display": "flow cytometry category",
      "definition": "Molecular biomarker method is flow cytometry."
    }, {
      "code": "immuneStain",
      "display": "immune stain category",
      "definition": "Molecular biomarker method is immune stain."
    }, {
      "code": "immunoassay",
      "display": "immunoassay category",
      "definition": "Molecular biomarker method is immunoassay."
    }, {
      "code": "methylationAnalysis",
      "display": "methylation analysis category",
      "definition": "Molecular biomarker method is methylation analysis."
    }, {
      "code": "molgen",
      "display": "molecular sequence adjacent category",
      "definition": "Molecular biomarker method is molecular sequence adjacent observation."
    } ],
    "display": "Molecular biomarker method type category",
    "definition": "A category based on the measurement ascertainment method of the biomarker. (Methods are drawn from LOINC (https://loinc.org/kb/users-guide/major-parts-of-a-loinc-term/#type-of-method-6th-part) and NCBI Genetic Testing Registry (https://www.ncbi.nlm.nih.gov/gtr/))."
  } ],
  "caseSensitive": true,
  "version": "3.0.0",
  "contact": [ {
    "name": "HL7 International / Clinical Genomics",
    "telecom": [ {
      "value": "http://www.hl7.org/Special/committees/clingenomics",
      "system": "url"
    }, {
      "value": "cg@lists.HL7.org",
      "system": "email"
    } ]
  } ]
}