{
  "description": "Der HRD-Score, welcher den Grad der homologen Rekombinationsdefizienz bei Zellen beschreibt.",
  "_filename": "StructureDefinition-mii-pr-mtb-hrd-score.json",
  "package_name": "de.medizininformatikinitiative.kerndatensatz.mtb",
  "date": null,
  "derivation": "constraint",
  "publisher": "Medizininformatik Initiative",
  "fhirVersion": "4.0.1",
  "name": "MII_PR_MTB_HRD_Score",
  "abstract": false,
  "type": "Observation",
  "experimental": null,
  "resourceType": "StructureDefinition",
  "title": "MII PR MTB HRD Score",
  "package_version": "2025.0.0-ballot",
  "status": "draft",
  "id": "9acd87e6-e18c-43ac-a02d-6b2d0adfcde4",
  "kind": "resource",
  "url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-hrd-score",
  "version": "2024.0.0-ballot",
  "differential": {
    "element": [ {
      "id": "Observation.identifier",
      "path": "Observation.identifier",
      "mustSupport": true
    }, {
      "id": "Observation.category",
      "path": "Observation.category",
      "mustSupport": true
    }, {
      "id": "Observation.code",
      "path": "Observation.code",
      "patternCodeableConcept": {
        "coding": [ {
          "code": "107286-7",
          "system": "http://loinc.org"
        } ]
      }
    }, {
      "id": "Observation.subject",
      "min": 1,
      "path": "Observation.subject",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "http://hl7.org/fhir/StructureDefinition/Patient", "http://hl7.org/fhir/StructureDefinition/Group" ]
      } ],
      "mustSupport": true
    }, {
      "id": "Observation.encounter",
      "path": "Observation.encounter",
      "mustSupport": true
    }, {
      "id": "Observation.value[x]",
      "path": "Observation.value[x]",
      "type": [ {
        "code": "integer"
      } ],
      "short": "HRD-Score",
      "definition": "HRD-Score als Summe der LOH, TAI und LST-Werte",
      "mustSupport": true
    }, {
      "id": "Observation.interpretation",
      "path": "Observation.interpretation",
      "binding": {
        "strength": "required",
        "valueSet": "http://hl7.org/fhir/uv/genomics-reporting/ValueSet/high-low-codes-vs"
      },
      "mustSupport": true
    }, {
      "id": "Observation.specimen",
      "path": "Observation.specimen",
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    }, {
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      "path": "Observation.component",
      "slicing": {
        "rules": "closed",
        "ordered": false,
        "description": "Elements of the HRD Score",
        "discriminator": [ {
          "path": "code",
          "type": "value"
        } ]
      }
    }, {
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      "max": "1",
      "min": 0,
      "path": "Observation.component",
      "short": "Loss of heterozygosity",
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      "mustSupport": true
    }, {
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      "path": "Observation.component.code",
      "patternCodeableConcept": {
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          "system": "https://nih-ncpi.github.io/ncpi-fhir-ig/CodeSystem-ncit.html",
          "display": "Loss of Heterozygosity"
        } ]
      }
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      "mustSupport": true
    }, {
      "id": "Observation.component:TAI",
      "max": "1",
      "min": 0,
      "path": "Observation.component",
      "short": "Telomeric allelic imbalance",
      "sliceName": "TAI",
      "mustSupport": true
    }, {
      "id": "Observation.component:TAI.code",
      "path": "Observation.component.code",
      "patternCodeableConcept": {
        "coding": [ {
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          "system": "https://nih-ncpi.github.io/ncpi-fhir-ig/CodeSystem-ncit.html",
          "display": "Telomeric Allelic Imbalance Region"
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    }, {
      "id": "Observation.component:LST",
      "max": "1",
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      "short": "Large-scale state transitions",
      "sliceName": "LST",
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    }, {
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      "path": "Observation.component.code",
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    "telecom": [ {
      "value": "https://www.medizininformatik-initiative.de",
      "system": "url"
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  } ],
  "baseDefinition": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-molekularer-biomarker"
}