description: Profile with properties for observations that convey the potential impact of genomic characteristics on a medication or non-medicinal therapy.
package_name: hl7.fhir.uv.genomics
derivation: constraint
name: TherapeuticImplication
type: Observation
elements:
  extension:
    type: Extension
    url: http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapy-assessed
    index: 0
    slicing:
      slices:
        therapy-assessed:
          match: {}
          schema: {type: Extension, url: 'http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapy-assessed', index: 0}
          min: 0
        medication-assessed:
          match: {}
          schema: {type: Extension, url: 'http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/medication-assessed', index: 1}
          min: 0
  code:
    short: therapeutic-implication
    pattern:
      type: CodeableConcept
      value:
        coding:
        - {code: therapeutic-implication, system: 'http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs'}
    index: 2
  component:
    short: Phenotypic treatment context
    array: true
    index: 3
    slicing:
      slices:
        phenotypic-treatment-context:
          match: {}
          schema:
            short: Phenotypic treatment context
            array: true
            index: 3
            elements:
              code:
                short: 81259-4
                pattern:
                  type: CodeableConcept
                  value:
                    coding:
                    - {code: 81259-4, system: 'http://loinc.org'}
                index: 4
              value:
                short: Contextual phenotype/condition code
                choices: [valueCodeableConcept]
                index: 6
              valueCodeableConcept: {type: CodeableConcept, short: Contextual phenotype/condition code, choiceOf: value, index: 7}
            required: [value, valueCodeableConcept]
        medication-assessed:
          match: {}
          schema:
            short: Medication Assessed
            array: true
            index: 8
            elements:
              code:
                short: 51963-7
                pattern:
                  type: CodeableConcept
                  value:
                    coding:
                    - {code: 51963-7, system: 'http://loinc.org'}
                index: 9
              value:
                short: Medication code
                choices: [valueCodeableConcept]
                index: 11
              valueCodeableConcept: {type: CodeableConcept, short: Medication code, choiceOf: value, index: 12}
            required: [value, valueCodeableConcept]
        therapy-assessed:
          match: {}
          schema:
            short: Non-medication therapy assessed
            array: true
            index: 13
            elements:
              code:
                short: associated-therapy
                pattern:
                  type: CodeableConcept
                  value:
                    coding:
                    - {code: associated-therapy, system: 'http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs'}
                index: 14
              value:
                choices: [valueCodeableConcept]
                index: 16
              valueCodeableConcept: {type: CodeableConcept, choiceOf: value, index: 17}
            required: [value, valueCodeableConcept]
        predicted-therapeutic-implication:
          match: {}
          schema:
            short: Predicted Therapeutic Implication
            array: true
            index: 18
            elements:
              code:
                short: predicted-therapeutic-implication
                pattern:
                  type: CodeableConcept
                  value:
                    coding:
                    - {code: predicted-therapeutic-implication, system: 'http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs'}
                index: 19
              value:
                short: Responsive | Resistant | Poor metabolizer | Rapid metabolizer | Decreased function | Increased function | Does not meet eligibility criteria for clinical trial | ... (more)
                choices: [valueCodeableConcept]
                index: 21
              valueCodeableConcept: {type: CodeableConcept, short: Responsive | Resistant | Poor metabolizer | Rapid metabolizer | Decreased function | Increased function | Does not meet eligibility criteria for clinical trial | ... (more), choiceOf: value, index: 22}
            required: [value, valueCodeableConcept]
package_version: reporting-2.0.0
extensions:
  therapy-assessed: {url: 'http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapy-assessed', min: 0, type: Extension, index: 0}
  medication-assessed: {url: 'http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/medication-assessed', min: 0, type: Extension, index: 1}
class: profile
kind: resource
url: http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication
base: http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/implication
version: 2.0.0