{
  "description": "0.4% incidence of fatal intracranial hemorrhage within 7 days without alteplase in patients with acute ischemic stroke",
  "_filename": "Evidence-example-stroke-no-alteplase-fatalICH.json",
  "package_name": "hl7.fhir.r6.examples",
  "statistic": [ {
    "quantity": {
      "value": 0.00386298627
    },
    "sampleSize": {
      "numberOfStudies": 9,
      "numberOfParticipants": 3365
    },
    "statisticType": {
      "coding": [ {
        "code": "STATO:0000607",
        "system": "https://fevir.net/sevco",
        "display": "proportion"
      } ]
    },
    "numberOfEvents": 13
  } ],
  "date": null,
  "publisher": "HL7 International / Clinical Decision Support",
  "name": "RiskOfFatalICHWithoutAlteplaseForStroke",
  "type": null,
  "experimental": null,
  "resourceType": "Evidence",
  "variableDefinition": [ {
    "intended": {
      "type": "Group",
      "display": "adults with acute ischemic stroke treated without alteplase",
      "reference": "Group/AcuteIschemicStrokeTreatedWithoutAlteplase"
    },
    "observed": {
      "type": "Group",
      "display": "Emberson 2014 IPD-MA No Alteplase Cohort",
      "reference": "Group/Emberson-2014-IPD-MA-No-Alteplase-Cohort"
    },
    "variableRole": "population"
  }, {
    "intended": {
      "type": "EvidenceVariable",
      "display": "fatal ICH",
      "reference": "EvidenceVariable/example-fatal-ICH-in-7-days"
    },
    "observed": {
      "type": "EvidenceVariable",
      "display": "fatal ICH",
      "reference": "EvidenceVariable/example-fatal-ICH-in-7-days"
    },
    "variableRole": "outcome"
  } ],
  "title": "Risk of fatal ICH without alteplase for stroke",
  "package_version": "6.0.0-ballot4",
  "synthesisType": [ {
    "coding": [ {
      "code": "IPD-MA",
      "system": "http://terminology.hl7.org/CodeSystem/synthesis-type",
      "display": "individual patient data meta-analysis"
    } ]
  } ],
  "extension": [ {
    "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg",
    "valueCode": "cds"
  } ],
  "status": "draft",
  "id": "78073d44-c0e5-4af1-ae47-8a23eae4e88d",
  "kind": null,
  "url": "http://hl7.org/fhir/Evidence/example-stroke-no-alteplase-fatalICH",
  "identifier": [ {
    "value": "urn:oid:2.16.840.1.113883.4.642.10.4",
    "system": "urn:ietf:rfc:3986"
  } ],
  "relatesTo": [ {
    "type": {
      "coding": [ {
        "code": "cites",
        "system": "http://terminology.hl7.org/CodeSystem/artifact-relationship-type",
        "display": "Cites"
      } ]
    },
    "targetMarkdown": "Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Citation: Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, et al;Stroke Thrombolysis Trialists' Collaborative Group. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014 Nov 29;384(9958):1929-35 PMID 25106063 URL: https://doi.org/10.1016/S0140-6736(14)60584-5"
  } ],
  "version": null,
  "studyDesign": [ {
    "coding": [ {
      "code": "SEVCO:01003",
      "system": "https://fevir.net/sevco",
      "display": "randomized assignment"
    } ]
  } ],
  "contact": [ {
    "telecom": [ {
      "value": "http://www.hl7.org/Special/committees/dss",
      "system": "url"
    } ]
  } ]
}