description: Beschreibt die BRCAness, also wie sehr ein Tumor ein Verhalten zeigt, welches BRCA1- oder BRCA2-Mutationen entspricht. Die BRCAness ist ein Indikator für die Wirksamkeit von PARP-Inhibitoren.
package_name: de.medizininformatikinitiative.kerndatensatz.mtb
derivation: constraint
name: MII_PR_MTB_BRCAness
type: Observation
elements:
  identifier:
    short: Biomarker-ID im Kontext des NGS-Befundes
    _short:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: Biomarker-ID im Kontext des NGS-Befundes}
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: en}
        - {url: content, valueString: Biomarker ID in the context of the NGS report}
    _definition:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: Eindeutige Biomarker-ID im Kontext des NGS-Befundes.}
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: en}
        - {url: content, valueString: Unique biomarker ID in the context of the NGS report.}
    mustSupport: true
    index: 0
  code:
    short: BRCAness
    _short:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: BRCAness}
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: en}
        - {url: content, valueString: BRCAness}
    _definition:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: BRCAness der Tumormutationsmuster}
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: en}
        - {url: content, valueString: BRCAness of tumor mutation patterns}
    pattern:
      type: CodeableConcept
      value:
        coding:
        - {code: brcaness, system: 'https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker'}
    index: 1
  subject: {index: 2}
  value:
    mustSupport: true
    choices: []
    index: 4
    slicing:
      rules: open
      ordered: false
      discriminator:
      - {path: $this, type: type}
      min: null
      slices:
        valueQuantity:
          match: {}
          schema:
            mustSupport: true
            choices: [valueQuantity]
            index: 6
          min: 0
          max: 1
  valueQuantity:
    type: Quantity
    mustSupport: true
    choiceOf: value
    index: 7
    slicing:
      slices:
        valueQuantity:
          match: {}
          schema: {type: Quantity, mustSupport: true, choiceOf: value, index: 7}
          min: 0
          max: 1
  value[x]:
    elements:
      value: {mustSupport: true, index: 8}
      unit:
        pattern: {type: String, value: Score}
        index: 9
      system:
        pattern: {type: Uri, value: 'http://unitsofmeasure.org'}
        index: 10
      code:
        pattern: {type: Code, value: '1'}
        index: 11
  interpretation:
    binding: {strength: required, valueSet: 'http://hl7.org/fhir/uv/genomics-reporting/ValueSet/high-low-codes-vs'}
    mustSupport: true
    index: 12
  specimen: {mustSupport: true, index: 13}
package_version: 2026.0.1
class: profile
kind: resource
url: https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-brcaness
base: https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-molekularer-biomarker
version: 2026.0.1
required: [subject]