description: Dieses Profil beschreibt molekulare Biomarker, z.B. genübergreifende Biomarker wie Tumormutationslast (TMB) oder Mikrosatelliteninstabilität (MSI). Es ist ein abstraktes Profil, konkrete Biomarker-Profile erben davon.
package_name: de.medizininformatikinitiative.kerndatensatz.molgen
derivation: constraint
name: MII_PR_MolGen_MolekularerBiomarker
type: Observation
elements:
  category:
    short: Kategorie
    _short:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: Kategorie}
    _definition:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: Klassifizierung der Beobachtungsart}
    mustSupport: true
    index: 0
  code:
    short: Code
    _short:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: Code}
    _definition:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: Code zur Identifizierung des Biomarkers}
    mustSupport: true
    index: 1
  subject:
    short: Patient
    _definition:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: Der Patient auf den sich die Beobachtung bezieht}
    refers: ['http://hl7.org/fhir/StructureDefinition/Group', 'http://hl7.org/fhir/StructureDefinition/Patient']
    type: Reference
    mustSupport: true
    _short:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: Patient}
    index: 2
  encounter:
    short: Kontakt
    _short:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: Kontakt}
    _definition:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: Der Kontakt in dessen Rahmen die Beobachtung gemacht wurde}
    mustSupport: true
    index: 3
  effective:
    short: Zeitpunkt der Beobachtung
    _short:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: Zeitpunkt der Beobachtung}
    _definition:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: Klinisch relevanter Zeitpunkt der Beobachtung}
    mustSupport: true
    choices: []
    index: 5
  issued:
    short: Freigabedatum
    _short:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: Freigabedatum}
    _definition:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: Datum und Uhrzeit der Freigabe}
    mustSupport: true
    index: 6
  derivedFrom:
    short: Abgeleitet von
    _short:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: Abgeleitet von}
    _definition:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: Referenzen zu anderen Beobachtungen von denen diese abgeleitet ist}
    mustSupport: true
    index: 7
    slicing:
      slices:
        variant:
          match: {}
          schema:
            type: Reference
            refers: ['https://www.medizininformatik-initiative.de/fhir/ext/modul-molgen/StructureDefinition/variante']
            index: 8
  component:
    short: Komponenten
    _short:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: Komponenten}
    _definition:
      extension:
      - url: http://hl7.org/fhir/StructureDefinition/translation
        extension:
        - {url: lang, valueCode: de-DE}
        - {url: content, valueString: Einzelne Komponenten der Beobachtung}
    mustSupport: true
    index: 9
    slicing:
      slices:
        gene-studied:
          match: {}
          schema:
            short: Untersuchtes Gen
            _short:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: Untersuchtes Gen}
            _definition:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: Das untersuchte Gen}
            mustSupport: true
            index: 10
        biomarker-category:
          match: {}
          schema:
            short: Biomarker-Kategorie
            _short:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: Biomarker-Kategorie}
            _definition:
              extension:
              - url: http://hl7.org/fhir/StructureDefinition/translation
                extension:
                - {url: lang, valueCode: de-DE}
                - {url: content, valueString: Die Kategorie des molekularen Biomarkers}
            mustSupport: true
            index: 11
package_version: 2026.0.0
class: profile
kind: resource
url: https://www.medizininformatik-initiative.de/fhir/ext/modul-molgen/StructureDefinition/mii-pr-molgen-molekularer-biomarker
base: http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-biomarker
version: 2026.0.0