{ "description": "This cross-version extension represents SubstanceNucleicAcid from http://hl7.org/fhir/StructureDefinition/SubstanceNucleicAcid|4.0.1 for use in FHIR R5.", "_filename": "StructureDefinition-ext-R4-SubstanceNucleicAcid.json", "package_name": "rs/hl7.fhir.uv.xver", "date": "2025-06-03T03:13:12.3837633+02:00", "derivation": "constraint", "publisher": null, "fhirVersion": "5.0.0", "name": "ext_R4_SubstanceNucleicAcid", "abstract": false, "type": "Extension", "experimental": "false", "resourceType": "StructureDefinition", "title": "Cross-version Extension for R4.SubstanceNucleicAcid for use in FHIR R5", "package_version": "r4.r5-0.0.1-snapshot-1", "snapshot": { "element": [ { "constraint": [ { "key": "ele-1", "human": "All FHIR elements must have a @value or children", "source": "http://hl7.org/fhir/StructureDefinition/Element", "severity": "error", "expression": "hasValue() or (children().count() > id.count())" }, { "key": "ext-1", "human": "Must have either extensions or value[x], not both", "source": "http://hl7.org/fhir/StructureDefinition/Extension", "severity": "error", "expression": "extension.exists() != value.exists()" } ], "path": "Extension", "min": 0, "definition": "Optional Extension Element - found in all resources.", "isModifier": false, "short": "Nucleic acids are defined by three distinct elements: the base, sugar and linkage. 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The definition SHALL be a URI for the Structure Definition defining the extension.", "base": { "max": "1", "min": 1, "path": "Extension.url" }, "isSummary": false }, { "constraint": [ { "key": "ele-1", "human": "All FHIR elements must have a @value or children", "source": "http://hl7.org/fhir/StructureDefinition/Element", "severity": "error", "expression": "hasValue() or (children().count() > id.count())" } ], "path": "Extension.extension.extension.extension.value[x]", "min": 0, "definition": "Value of extension - must be one of a constrained set of the data types (see [Extensibility](extensibility.html) for a list).", "isModifier": false, "short": "The Substance ID of the sugar or sugar-like component that make up the nucleotide", "mapping": [ { "map": "N/A", "identity": "rim" } ], "type": [ { "code": "Identifier" } ], "max": "1", "id": "Extension.extension:subunit.extension:sugar.extension:identifier.value[x]", "condition": [ "ext-1" ], "base": { "max": "1", "min": 0, "path": "Extension.value[x]" }, "isSummary": false }, { "constraint": [ { "key": "ele-1", "human": "All FHIR elements must have a @value or children", "source": "http://hl7.org/fhir/StructureDefinition/Element", "severity": "error", "expression": "hasValue() or (children().count() > id.count())" }, { "key": "ext-1", "human": "Must have either extensions or value[x], not both", "source": "http://hl7.org/fhir/StructureDefinition/Extension", "severity": "error", "expression": "extension.exists() != value.exists()" } ], "path": "Extension.extension.extension.extension", "min": 0, "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.", "isModifier": false, "short": "The name of the sugar or sugar-like component that make up the nucleotide", "mapping": [ { "map": "n/a", "identity": "rim" } ], "type": [ { "code": "Extension" } ], "sliceName": "name", "alias": [ "extensions", "user content" ], "max": "1", "id": "Extension.extension:subunit.extension:sugar.extension:name", "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.", "base": { "max": "*", "min": 0, "path": "Element.extension" }, "isSummary": false }, { "path": "Extension.extension.extension.extension.id", "min": 0, "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.", "isModifier": false, "short": "Unique id for inter-element referencing", "mapping": [ { "map": "n/a", "identity": "rim" } ], "type": [ { "code": "http://hl7.org/fhirpath/System.String", "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type", "valueUrl": "id" } ] } ], "representation": [ "xmlAttr" ], "max": "1", "id": "Extension.extension:subunit.extension:sugar.extension:name.id", "condition": [ "ele-1" ], "base": { "max": "1", "min": 0, "path": "Element.id" }, "isSummary": false }, { "constraint": [ { "key": "ele-1", "human": "All FHIR elements must have a @value or children", "source": "http://hl7.org/fhir/StructureDefinition/Element", "severity": "error", "expression": "hasValue() or (children().count() > id.count())" }, { "key": "ext-1", "human": "Must have either extensions or value[x], not both", "source": "http://hl7.org/fhir/StructureDefinition/Extension", "severity": "error", "expression": "extension.exists() != value.exists()" } ], "path": "Extension.extension.extension.extension.extension", "min": 0, "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.", "isModifier": false, "short": "Additional content defined by implementations", "mapping": [ { "map": "n/a", "identity": "rim" } ], "slicing": { "rules": "open", "description": "Extensions are always sliced by (at least) url", "discriminator": [ { "path": "url", "type": "value" } ] }, "type": [ { "code": "Extension" } ], "alias": [ "extensions", "user content" ], "max": "*", "id": "Extension.extension:subunit.extension:sugar.extension:name.extension", "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.", "base": { "max": "*", "min": 0, "path": "Element.extension" }, "isSummary": false }, { "path": "Extension.extension.extension.extension.url", "min": 1, "definition": "Source of the definition for the extension code - a logical name or a URL.", "isModifier": false, "short": "identifies the meaning of the extension", "fixedUri": "name", "mapping": [ { "map": "N/A", "identity": "rim" } ], "type": [ { "code": "http://hl7.org/fhirpath/System.String", "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type", "valueUrl": "uri" } ] } ], "representation": [ "xmlAttr" ], "max": "1", "id": "Extension.extension:subunit.extension:sugar.extension:name.url", "comment": "The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.", "base": { "max": "1", "min": 1, "path": "Extension.url" }, "isSummary": false }, { "constraint": [ { "key": "ele-1", "human": "All FHIR elements must have a @value or children", "source": "http://hl7.org/fhir/StructureDefinition/Element", "severity": "error", "expression": "hasValue() or (children().count() > id.count())" } ], "path": "Extension.extension.extension.extension.value[x]", "min": 0, "definition": "Value of extension - must be one of a constrained set of the data types (see [Extensibility](extensibility.html) for a list).", "isModifier": false, "short": "The name of the sugar or sugar-like component that make up the nucleotide", "mapping": [ { "map": "N/A", "identity": "rim" } ], "type": [ { "code": "string" } ], "max": "1", "id": "Extension.extension:subunit.extension:sugar.extension:name.value[x]", "condition": [ "ext-1" ], "base": { "max": "1", "min": 0, "path": "Extension.value[x]" }, "isSummary": false }, { "constraint": [ { "key": "ele-1", "human": "All FHIR elements must have a @value or children", "source": "http://hl7.org/fhir/StructureDefinition/Element", "severity": "error", "expression": "hasValue() or (children().count() > id.count())" }, { "key": "ext-1", "human": "Must have either extensions or value[x], not both", "source": "http://hl7.org/fhir/StructureDefinition/Extension", "severity": "error", "expression": "extension.exists() != value.exists()" } ], "path": "Extension.extension.extension.extension", "min": 0, "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.", "isModifier": false, "short": "The residues that contain a given sugar will be captured. The order of given residues will be captured in the 5‘-3‘direction consistent with the base sequences listed above", "mapping": [ { "map": "n/a", "identity": "rim" } ], "type": [ { "code": "Extension" } ], "sliceName": "residueSite", "alias": [ "extensions", "user content" ], "max": "1", "id": "Extension.extension:subunit.extension:sugar.extension:residueSite", "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.", "base": { "max": "*", "min": 0, "path": "Element.extension" }, "isSummary": false }, { "path": "Extension.extension.extension.extension.id", "min": 0, "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.", "isModifier": false, "short": "Unique id for inter-element referencing", "mapping": [ { "map": "n/a", "identity": "rim" } ], "type": [ { "code": "http://hl7.org/fhirpath/System.String", "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type", "valueUrl": "id" } ] } ], "representation": [ "xmlAttr" ], "max": "1", "id": "Extension.extension:subunit.extension:sugar.extension:residueSite.id", "condition": [ "ele-1" ], "base": { "max": "1", "min": 0, "path": "Element.id" }, "isSummary": false }, { "constraint": [ { "key": "ele-1", "human": "All FHIR elements must have a @value or children", "source": "http://hl7.org/fhir/StructureDefinition/Element", "severity": "error", "expression": "hasValue() or (children().count() > id.count())" }, { "key": "ext-1", "human": "Must have either extensions or value[x], not both", "source": "http://hl7.org/fhir/StructureDefinition/Extension", "severity": "error", "expression": "extension.exists() != value.exists()" } ], "path": "Extension.extension.extension.extension.extension", "min": 0, "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.", "isModifier": false, "short": "Additional content defined by implementations", "mapping": [ { "map": "n/a", "identity": "rim" } ], "slicing": { "rules": "open", "description": "Extensions are always sliced by (at least) url", "discriminator": [ { "path": "url", "type": "value" } ] }, "type": [ { "code": "Extension" } ], "alias": [ "extensions", "user content" ], "max": "*", "id": "Extension.extension:subunit.extension:sugar.extension:residueSite.extension", "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.", "base": { "max": "*", "min": 0, "path": "Element.extension" }, "isSummary": false }, { "path": "Extension.extension.extension.extension.url", "min": 1, "definition": "Source of the definition for the extension code - a logical name or a URL.", "isModifier": false, "short": "identifies the meaning of the extension", "fixedUri": "residueSite", "mapping": [ { "map": "N/A", "identity": "rim" } ], "type": [ { "code": "http://hl7.org/fhirpath/System.String", "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type", "valueUrl": "uri" } ] } ], "representation": [ "xmlAttr" ], "max": "1", "id": "Extension.extension:subunit.extension:sugar.extension:residueSite.url", "comment": "The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.", "base": { "max": "1", "min": 1, "path": "Extension.url" }, "isSummary": false }, { "constraint": [ { "key": "ele-1", "human": "All FHIR elements must have a @value or children", "source": "http://hl7.org/fhir/StructureDefinition/Element", "severity": "error", "expression": "hasValue() or (children().count() > id.count())" } ], "path": "Extension.extension.extension.extension.value[x]", "min": 0, "definition": "Value of extension - must be one of a constrained set of the data types (see [Extensibility](extensibility.html) for a list).", "isModifier": false, "short": "The residues that contain a given sugar will be captured. The order of given residues will be captured in the 5‘-3‘direction consistent with the base sequences listed above", "mapping": [ { "map": "N/A", "identity": "rim" } ], "type": [ { "code": "string" } ], "max": "1", "id": "Extension.extension:subunit.extension:sugar.extension:residueSite.value[x]", "condition": [ "ext-1" ], "base": { "max": "1", "min": 0, "path": "Extension.value[x]" }, "isSummary": false }, { "path": "Extension.extension.extension.url", "min": 1, "definition": "Source of the definition for the extension code - a logical name or a URL.", "isModifier": false, "short": "identifies the meaning of the extension", "fixedUri": "sugar", "mapping": [ { "map": "N/A", "identity": "rim" } ], "type": [ { "code": "http://hl7.org/fhirpath/System.String", "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type", "valueUrl": "uri" } ] } ], "representation": [ "xmlAttr" ], "max": "1", "id": "Extension.extension:subunit.extension:sugar.url", "comment": "The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.", "base": { "max": "1", "min": 1, "path": "Extension.url" }, "isSummary": false }, { "constraint": [ { "key": "ele-1", "human": "All FHIR elements must have a @value or children", "source": "http://hl7.org/fhir/StructureDefinition/Element", "severity": "error", "expression": "hasValue() or (children().count() > id.count())" } ], "path": "Extension.extension.extension.value[x]", "min": 0, "definition": "Value of extension - must be one of a constrained set of the data types (see [Extensibility](extensibility.html) for a list).", "isModifier": false, "short": "Value of extension", "mapping": [ { "map": "N/A", "identity": "rim" } ], "type": [ { "code": "base64Binary" }, { "code": "boolean" }, { "code": "canonical" }, { "code": "code" }, { "code": "date" }, { "code": "dateTime" }, { "code": "decimal" }, { "code": "id" }, { "code": "instant" }, { "code": "integer" }, { "code": "integer64" }, { "code": "markdown" }, { "code": "oid" }, { "code": "positiveInt" }, { "code": "string" }, { "code": "time" }, { "code": "unsignedInt" }, { "code": "uri" }, { "code": "url" }, { "code": "uuid" }, { "code": "Address" }, { "code": "Age" }, { "code": "Annotation" }, { "code": "Attachment" }, { "code": "CodeableConcept" }, { "code": "CodeableReference" }, { "code": "Coding" }, { "code": "ContactPoint" }, { "code": "Count" }, { "code": "Distance" }, { "code": "Duration" }, { "code": "HumanName" }, { "code": "Identifier" }, { "code": "Money" }, { "code": "Period" }, { "code": "Quantity" }, { "code": "Range" }, { "code": "Ratio" }, { "code": "RatioRange" }, { "code": "Reference" }, { "code": "SampledData" }, { "code": "Signature" }, { "code": "Timing" }, { "code": "ContactDetail" }, { "code": "DataRequirement" }, { "code": "Expression" }, { "code": "ParameterDefinition" }, { "code": "RelatedArtifact" }, { "code": "TriggerDefinition" }, { "code": "UsageContext" }, { "code": "Availability" }, { "code": "ExtendedContactDetail" }, { "code": "Dosage" }, { "code": "Meta" } ], "max": "1", "id": "Extension.extension:subunit.extension:sugar.value[x]", "condition": [ "ext-1" ], "base": { "max": "1", "min": 0, "path": "Extension.value[x]" }, "isSummary": false }, { "path": "Extension.extension.url", "min": 1, "definition": "Source of the definition for the extension code - a logical name or a URL.", "isModifier": false, "short": "identifies the meaning of the extension", "fixedUri": "subunit", "mapping": [ { "map": "N/A", "identity": "rim" } ], "type": [ { "code": "http://hl7.org/fhirpath/System.String", "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type", "valueUrl": "uri" } ] } ], "representation": [ "xmlAttr" ], "max": "1", "id": "Extension.extension:subunit.url", "comment": "The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.", "base": { "max": "1", "min": 1, "path": "Extension.url" }, "isSummary": false }, { "constraint": [ { "key": "ele-1", "human": "All FHIR elements must have a @value or children", "source": "http://hl7.org/fhir/StructureDefinition/Element", "severity": "error", "expression": "hasValue() or (children().count() > id.count())" } ], "path": "Extension.extension.value[x]", "min": 0, "definition": "Value of extension - must be one of a constrained set of the data types (see [Extensibility](extensibility.html) for a list).", "isModifier": false, "short": "Value of extension", "mapping": [ { "map": "N/A", "identity": "rim" } ], "type": [ { "code": "base64Binary" }, { "code": "boolean" }, { "code": "canonical" }, { "code": "code" }, { "code": "date" }, { "code": "dateTime" }, { "code": "decimal" }, { "code": "id" }, { "code": "instant" }, { "code": "integer" }, { "code": "integer64" }, { "code": "markdown" }, { "code": "oid" }, { "code": "positiveInt" }, { "code": "string" }, { "code": "time" }, { "code": "unsignedInt" }, { "code": "uri" }, { "code": "url" }, { "code": "uuid" }, { "code": "Address" }, { "code": "Age" }, { "code": "Annotation" }, { "code": "Attachment" }, { "code": "CodeableConcept" }, { "code": "CodeableReference" }, { "code": "Coding" }, { "code": "ContactPoint" }, { "code": "Count" }, { "code": "Distance" }, { "code": "Duration" }, { "code": "HumanName" }, { "code": "Identifier" }, { "code": "Money" }, { "code": "Period" }, { "code": "Quantity" }, { "code": "Range" }, { "code": "Ratio" }, { "code": "RatioRange" }, { "code": "Reference" }, { "code": "SampledData" }, { "code": "Signature" }, { "code": "Timing" }, { "code": "ContactDetail" }, { "code": "DataRequirement" }, { "code": "Expression" }, { "code": "ParameterDefinition" }, { "code": "RelatedArtifact" }, { "code": "TriggerDefinition" }, { "code": "UsageContext" }, { "code": "Availability" }, { "code": "ExtendedContactDetail" }, { "code": "Dosage" }, { "code": "Meta" } ], "max": "1", "id": "Extension.extension:subunit.value[x]", "condition": [ "ext-1" ], "base": { "max": "1", "min": 0, "path": "Extension.value[x]" }, "isSummary": false }, { "path": "Extension.url", "min": 1, "definition": "Source of the definition for the extension code - a logical name or a URL.", "isModifier": false, "short": "identifies the meaning of the extension", "fixedUri": "http://hl7.org/fhir/4.0/StructureDefinition/extension-SubstanceNucleicAcid", "mapping": [ { "map": "N/A", "identity": "rim" } ], "type": [ { "code": "http://hl7.org/fhirpath/System.String", "extension": [ { "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type", "valueUrl": "uri" } ] } ], "representation": [ "xmlAttr" ], "max": "1", "id": "Extension.url", "comment": "The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.", "base": { "max": "1", "min": 1, "path": "Extension.url" }, "isSummary": false }, { "constraint": [ { "key": "ele-1", "human": "All FHIR elements must have a @value or children", "source": "http://hl7.org/fhir/StructureDefinition/Element", "severity": "error", "expression": "hasValue() or (children().count() > id.count())" } ], "path": "Extension.value[x]", "min": 0, "definition": "Value of extension - must be one of a constrained set of the data types (see [Extensibility](extensibility.html) for a list).", "isModifier": false, "short": "Value of extension", "mapping": [ { "map": "N/A", "identity": "rim" } ], "type": [ { "code": "base64Binary" }, { "code": "boolean" }, { "code": "canonical" }, { "code": "code" }, { "code": "date" }, { "code": "dateTime" }, { "code": "decimal" }, { "code": "id" }, { "code": "instant" }, { "code": "integer" }, { "code": "integer64" }, { "code": "markdown" }, { "code": "oid" }, { "code": "positiveInt" }, { "code": "string" }, { "code": "time" }, { "code": "unsignedInt" }, { "code": "uri" }, { "code": "url" }, { "code": "uuid" }, { "code": "Address" }, { "code": "Age" }, { "code": "Annotation" }, { "code": "Attachment" }, { "code": "CodeableConcept" }, { "code": "CodeableReference" }, { "code": "Coding" }, { "code": "ContactPoint" }, { "code": "Count" }, { "code": "Distance" }, { "code": "Duration" }, { "code": "HumanName" }, { "code": "Identifier" }, { "code": "Money" }, { "code": "Period" }, { "code": "Quantity" }, { "code": "Range" }, { "code": "Ratio" }, { "code": "RatioRange" }, { "code": "Reference" }, { "code": "SampledData" }, { "code": "Signature" }, { "code": "Timing" }, { "code": "ContactDetail" }, { "code": "DataRequirement" }, { "code": "Expression" }, { "code": "ParameterDefinition" }, { "code": "RelatedArtifact" }, { "code": "TriggerDefinition" }, { "code": "UsageContext" }, { "code": "Availability" }, { "code": "ExtendedContactDetail" }, { "code": "Dosage" }, { "code": "Meta" } ], "max": "1", "id": "Extension.value[x]", "condition": [ "ext-1" ], "base": { "max": "1", "min": 0, "path": "Extension.value[x]" }, "isSummary": false } ] }, "status": "draft", "id": "5bcea48a-e901-4478-9b73-dcf2f853a7d6", "kind": "complex-type", "url": "http://hl7.org/fhir/4.0/StructureDefinition/extension-SubstanceNucleicAcid", "context": [ { "type": "element", "expression": "Basic" } ], "version": "0.0.1-snapshot-1", "differential": { "element": [ { "id": "Extension", "max": "*", "min": 0, "path": "Extension", "short": "Nucleic acids are defined by three distinct elements: the base, sugar and linkage. Individual substance/moiety IDs will be created for each of these elements. The nucleotide sequence will be always entered in the 5’-3’ direction", "isModifier": false }, { "id": "Extension.extension", "max": "*", "min": 0, "path": "Extension.extension", "slicing": { "rules": "closed", "ordered": false, "discriminator": [ { "path": "url", "type": "value" } ] } }, { "id": "Extension.extension:sequenceType", "max": "1", "min": 0, "path": "Extension.extension", "short": "The type of the sequence shall be specified based on a controlled vocabulary", "sliceName": "sequenceType", "isModifier": false }, { "id": "Extension.extension:sequenceType.value[x]", "base": { "path": "Extension.value[x]" }, "path": "Extension.extension.value[x]", "type": [ { "code": "CodeableConcept" } ], "short": "The type of the sequence shall be specified based on a controlled vocabulary" }, { "id": "Extension.extension:numberOfSubunits", "max": "1", "min": 0, "path": "Extension.extension", "short": "The number of linear sequences of nucleotides linked through phosphodiester bonds shall be described. Subunits would be strands of nucleic acids that are tightly associated typically through Watson-Crick base pairing. NOTE: If not specified in the reference source, the assumption is that there is 1 subunit", "sliceName": "numberOfSubunits", "isModifier": false }, { "id": "Extension.extension:numberOfSubunits.value[x]", "base": { "path": "Extension.value[x]" }, "path": "Extension.extension.value[x]", "type": [ { "code": "integer" } ], "short": "The number of linear sequences of nucleotides linked through phosphodiester bonds shall be described. Subunits would be strands of nucleic acids that are tightly associated typically through Watson-Crick base pairing. NOTE: If not specified in the reference source, the assumption is that there is 1 subunit" }, { "id": "Extension.extension:areaOfHybridisation", "max": "1", "min": 0, "path": "Extension.extension", "short": "The area of hybridisation shall be described if applicable for double stranded RNA or DNA. The number associated with the subunit followed by the number associated to the residue shall be specified in increasing order. The underscore “” shall be used as separator as follows: “Subunitnumber Residue”", "sliceName": "areaOfHybridisation", "isModifier": false }, { "id": "Extension.extension:areaOfHybridisation.value[x]", "base": { "path": "Extension.value[x]" }, "path": "Extension.extension.value[x]", "type": [ { "code": "string" } ], "short": "The area of hybridisation shall be described if applicable for double stranded RNA or DNA. The number associated with the subunit followed by the number associated to the residue shall be specified in increasing order. The underscore “” shall be used as separator as follows: “Subunitnumber Residue”" }, { "id": "Extension.extension:oligoNucleotideType", "max": "1", "min": 0, "path": "Extension.extension", "short": "(TBC)", "sliceName": "oligoNucleotideType", "isModifier": false }, { "id": "Extension.extension:oligoNucleotideType.value[x]", "base": { "path": "Extension.value[x]" }, "path": "Extension.extension.value[x]", "type": [ { "code": "CodeableConcept" } ], "short": "(TBC)" }, { "id": "Extension.extension:subunit", "max": "*", "min": 0, "path": "Extension.extension", "short": "Subunits are listed in order of decreasing length; sequences of the same length will be ordered by molecular weight; subunits that have identical sequences will be repeated multiple times", "sliceName": "subunit", "isModifier": false }, { "id": "Extension.extension:subunit.extension", "max": "*", "min": 0, "path": "Extension.extension.extension", "slicing": { "rules": "closed", "ordered": false, "discriminator": [ { "path": "url", "type": "value" } ] } }, { "id": "Extension.extension:subunit.extension:subunit", "max": "1", "min": 0, "path": "Extension.extension.extension", "short": "Index of linear sequences of nucleic acids in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts", "sliceName": "subunit", "isModifier": false }, { "id": "Extension.extension:subunit.extension:subunit.value[x]", "base": { "path": "Extension.value[x]" }, "path": "Extension.extension.extension.value[x]", "type": [ { "code": "integer" } ], "short": "Index of linear sequences of nucleic acids in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts" }, { "id": "Extension.extension:subunit.extension:sequence", "max": "1", "min": 0, "path": "Extension.extension.extension", "short": "Actual nucleotide sequence notation from 5' to 3' end using standard single letter codes. In addition to the base sequence, sugar and type of phosphate or non-phosphate linkage should also be captured", "sliceName": "sequence", "isModifier": false }, { "id": "Extension.extension:subunit.extension:sequence.value[x]", "base": { "path": "Extension.value[x]" }, "path": "Extension.extension.extension.value[x]", "type": [ { "code": "string" } ], "short": "Actual nucleotide sequence notation from 5' to 3' end using standard single letter codes. In addition to the base sequence, sugar and type of phosphate or non-phosphate linkage should also be captured" }, { "id": "Extension.extension:subunit.extension:length", "max": "1", "min": 0, "path": "Extension.extension.extension", "short": "The length of the sequence shall be captured", "sliceName": "length", "isModifier": false }, { "id": "Extension.extension:subunit.extension:length.value[x]", "base": { "path": "Extension.value[x]" }, "path": "Extension.extension.extension.value[x]", "type": [ { "code": "integer" } ], "short": "The length of the sequence shall be captured" }, { "id": "Extension.extension:subunit.extension:sequenceAttachment", "max": "1", "min": 0, "path": "Extension.extension.extension", "short": "(TBC)", "sliceName": "sequenceAttachment", "isModifier": false }, { "id": "Extension.extension:subunit.extension:sequenceAttachment.value[x]", "base": { "path": "Extension.value[x]" }, "path": "Extension.extension.extension.value[x]", "type": [ { "code": "Attachment" } ], "short": "(TBC)" }, { "id": "Extension.extension:subunit.extension:fivePrime", "max": "1", "min": 0, "path": "Extension.extension.extension", "short": "The nucleotide present at the 5’ terminal shall be specified based on a controlled vocabulary. Since the sequence is represented from the 5' to the 3' end, the 5’ prime nucleotide is the letter at the first position in the sequence. A separate representation would be redundant", "sliceName": "fivePrime", "isModifier": false }, { "id": "Extension.extension:subunit.extension:fivePrime.value[x]", "base": { "path": "Extension.value[x]" }, "path": "Extension.extension.extension.value[x]", "type": [ { "code": "CodeableConcept" } ], "short": "The nucleotide present at the 5’ terminal shall be specified based on a controlled vocabulary. Since the sequence is represented from the 5' to the 3' end, the 5’ prime nucleotide is the letter at the first position in the sequence. A separate representation would be redundant" }, { "id": "Extension.extension:subunit.extension:threePrime", "max": "1", "min": 0, "path": "Extension.extension.extension", "short": "The nucleotide present at the 3’ terminal shall be specified based on a controlled vocabulary. Since the sequence is represented from the 5' to the 3' end, the 5’ prime nucleotide is the letter at the last position in the sequence. A separate representation would be redundant", "sliceName": "threePrime", "isModifier": false }, { "id": "Extension.extension:subunit.extension:threePrime.value[x]", "base": { "path": "Extension.value[x]" }, "path": "Extension.extension.extension.value[x]", "type": [ { "code": "CodeableConcept" } ], "short": "The nucleotide present at the 3’ terminal shall be specified based on a controlled vocabulary. Since the sequence is represented from the 5' to the 3' end, the 5’ prime nucleotide is the letter at the last position in the sequence. A separate representation would be redundant" }, { "id": "Extension.extension:subunit.extension:linkage", "max": "*", "min": 0, "path": "Extension.extension.extension", "short": "The linkages between sugar residues will also be captured", "sliceName": "linkage", "isModifier": false }, { "id": "Extension.extension:subunit.extension:linkage.extension", "max": "*", "min": 0, "path": "Extension.extension.extension.extension", "slicing": { "rules": "closed", "ordered": false, "discriminator": [ { "path": "url", "type": "value" } ] } }, { "id": "Extension.extension:subunit.extension:linkage.extension:connectivity", "max": "1", "min": 0, "path": "Extension.extension.extension.extension", "short": "The entity that links the sugar residues together should also be captured for nearly all naturally occurring nucleic acid the linkage is a phosphate group. For many synthetic oligonucleotides phosphorothioate linkages are often seen. Linkage connectivity is assumed to be 3’-5’. If the linkage is either 3’-3’ or 5’-5’ this should be specified", "sliceName": "connectivity", "isModifier": false }, { "id": "Extension.extension:subunit.extension:linkage.extension:connectivity.value[x]", "base": { "path": "Extension.value[x]" }, "path": "Extension.extension.extension.extension.value[x]", "type": [ { "code": "string" } ], "short": "The entity that links the sugar residues together should also be captured for nearly all naturally occurring nucleic acid the linkage is a phosphate group. For many synthetic oligonucleotides phosphorothioate linkages are often seen. Linkage connectivity is assumed to be 3’-5’. If the linkage is either 3’-3’ or 5’-5’ this should be specified" }, { "id": "Extension.extension:subunit.extension:linkage.extension:identifier", "max": "1", "min": 0, "path": "Extension.extension.extension.extension", "short": "Each linkage will be registered as a fragment and have an ID", "sliceName": "identifier", "isModifier": false }, { "id": "Extension.extension:subunit.extension:linkage.extension:identifier.value[x]", "base": { "path": "Extension.value[x]" }, "path": "Extension.extension.extension.extension.value[x]", "type": [ { "code": "Identifier" } ], "short": "Each linkage will be registered as a fragment and have an ID" }, { "id": "Extension.extension:subunit.extension:linkage.extension:name", "max": "1", "min": 0, "path": "Extension.extension.extension.extension", "short": "Each linkage will be registered as a fragment and have at least one name. A single name shall be assigned to each linkage", "sliceName": "name", "isModifier": false }, { "id": "Extension.extension:subunit.extension:linkage.extension:name.value[x]", "base": { "path": "Extension.value[x]" }, "path": "Extension.extension.extension.extension.value[x]", "type": [ { "code": "string" } ], "short": "Each linkage will be registered as a fragment and have at least one name. A single name shall be assigned to each linkage" }, { "id": "Extension.extension:subunit.extension:linkage.extension:residueSite", "max": "1", "min": 0, "path": "Extension.extension.extension.extension", "short": "Residues shall be captured as described in 5.3.6.8.3", "sliceName": "residueSite", "isModifier": false }, { "id": "Extension.extension:subunit.extension:linkage.extension:residueSite.value[x]", "base": { "path": "Extension.value[x]" }, "path": "Extension.extension.extension.extension.value[x]", "type": [ { "code": "string" } ], "short": "Residues shall be captured as described in 5.3.6.8.3" }, { "id": "Extension.extension:subunit.extension:sugar", "max": "*", "min": 0, "path": "Extension.extension.extension", "short": "5.3.6.8.1 Sugar ID (Mandatory)", "sliceName": "sugar", "isModifier": false }, { "id": "Extension.extension:subunit.extension:sugar.extension", "max": "*", "min": 0, "path": "Extension.extension.extension.extension", "slicing": { "rules": "closed", "ordered": false, "discriminator": [ { "path": "url", "type": "value" } ] } }, { "id": "Extension.extension:subunit.extension:sugar.extension:identifier", "max": "1", "min": 0, "path": "Extension.extension.extension.extension", "short": "The Substance ID of the sugar or sugar-like component that make up the nucleotide", "sliceName": "identifier", "isModifier": false }, { "id": "Extension.extension:subunit.extension:sugar.extension:identifier.value[x]", "base": { "path": "Extension.value[x]" }, "path": "Extension.extension.extension.extension.value[x]", "type": [ { "code": "Identifier" } ], "short": "The Substance ID of the sugar or sugar-like component that make up the nucleotide" }, { "id": "Extension.extension:subunit.extension:sugar.extension:name", "max": "1", "min": 0, "path": "Extension.extension.extension.extension", "short": "The name of the sugar or sugar-like component that make up the nucleotide", "sliceName": "name", "isModifier": false }, { "id": "Extension.extension:subunit.extension:sugar.extension:name.value[x]", "base": { "path": "Extension.value[x]" }, "path": "Extension.extension.extension.extension.value[x]", "type": [ { "code": "string" } ], "short": "The name of the sugar or sugar-like component that make up the nucleotide" }, { "id": "Extension.extension:subunit.extension:sugar.extension:residueSite", "max": "1", "min": 0, "path": "Extension.extension.extension.extension", "short": "The residues that contain a given sugar will be captured. The order of given residues will be captured in the 5‘-3‘direction consistent with the base sequences listed above", "sliceName": "residueSite", "isModifier": false }, { "id": "Extension.extension:subunit.extension:sugar.extension:residueSite.value[x]", "base": { "path": "Extension.value[x]" }, "path": "Extension.extension.extension.extension.value[x]", "type": [ { "code": "string" } ], "short": "The residues that contain a given sugar will be captured. The order of given residues will be captured in the 5‘-3‘direction consistent with the base sequences listed above" }, { "id": "Extension.url", "max": "1", "min": 1, "path": "Extension.url", "fixedUri": "http://hl7.org/fhir/4.0/StructureDefinition/extension-SubstanceNucleicAcid" } ] }, "baseDefinition": "http://hl7.org/fhir/StructureDefinition/Extension" }