description: A single evidence for an outcome from a specific study, meta analysis or systematic review.
package_name: de.netzwerk
derivation: constraint
name: OutcomeEvidence
abstract: true
type: Evidence
elements:
  name: {index: 0}
  relatedArtifact:
    mustSupport: true
    index: 1
    slicing:
      rules: open
      discriminator:
      - {path: type, type: pattern}
      min: 1
      slices:
        studyCitation:
          match: {type: citation}
          schema:
            mustSupport: true
            array: true
            min: 1
            _required: true
            index: 2
            elements:
              type:
                pattern: {type: Code, value: citation}
                index: 3
              resourceReference:
                type: Reference
                mustSupport: true
                refers: ['https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/study-citation']
                index: 4
            required: [resourceReference]
  variableDefinition:
    array: true
    min: 2
    index: 5
    slicing:
      rules: open
      discriminator:
      - {path: variableRole, type: value}
      min: 2
      slices:
        population:
          match:
            variableRole:
              coding:
              - {code: population, system: 'http://terminology.hl7.org/CodeSystem/variable-role'}
          schema:
            mustSupport: true
            _required: true
            index: 6
            elements:
              variableRole:
                pattern:
                  type: CodeableConcept
                  value:
                    coding:
                    - {code: population, system: 'http://terminology.hl7.org/CodeSystem/variable-role'}
                index: 7
              observed:
                type: Reference
                mustSupport: true
                refers: ['https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/cohorts']
                index: 8
              intended:
                type: Reference
                refers: ['https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/study-eligibility-criteria']
                index: 9
            required: [observed]
        outcome:
          match:
            variableRole:
              coding:
              - {code: measuredVariable, system: 'http://terminology.hl7.org/CodeSystem/variable-role'}
          schema:
            mustSupport: true
            _required: true
            index: 10
            elements:
              variableRole:
                pattern:
                  type: CodeableConcept
                  value:
                    coding:
                    - {code: measuredVariable, system: 'http://terminology.hl7.org/CodeSystem/variable-role'}
                index: 11
              observed: {mustSupport: true, index: 12}
              intended: {index: 13}
            required: [observed]
        intervention:
          match:
            variableRole:
              coding:
              - {code: exposure, system: 'http://terminology.hl7.org/CodeSystem/variable-role'}
          schema:
            array: true
            index: 14
            elements:
              variableRole:
                pattern:
                  type: CodeableConcept
                  value:
                    coding:
                    - {code: exposure, system: 'http://terminology.hl7.org/CodeSystem/variable-role'}
                index: 15
              observed:
                type: Reference
                mustSupport: true
                refers: ['https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/intervention-definition']
                index: 16
              intended: {index: 17}
            required: [observed]
        comparator:
          match:
            variableRole:
              coding:
              - {code: referenceExposure, system: 'http://terminology.hl7.org/CodeSystem/variable-role'}
          schema:
            array: true
            index: 18
            elements:
              variableRole:
                pattern:
                  type: CodeableConcept
                  value:
                    coding:
                    - {code: referenceExposure, system: 'http://terminology.hl7.org/CodeSystem/variable-role'}
                index: 19
              observed:
                type: Reference
                mustSupport: true
                refers: ['https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/intervention-definition']
                index: 20
              intended: {index: 21}
            required: [observed]
  synthesisType: {mustSupport: true, index: 22}
  statistic:
    mustSupport: true
    index: 23
    slicing:
      rules: open
      discriminator:
      - {path: statisticType, type: value}
      min: null
      slices:
        relativeEffect:
          match: {statisticType: null}
          schema:
            mustSupport: true
            index: 24
            elements:
              description:
                pattern: {type: Markdown, value: Relative effect of intervention vs. comparator}
                index: 25
              statisticType:
                binding: {strength: required, valueSet: 'https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/ValueSet/vs-relative-effect-type'}
                mustSupport: true
                index: 26
              quantity: {short: Relative Effect of the presented evidence (intervention vs. comparator) for dichotomous outcomes, mustSupport: true, index: 27}
              sampleSize:
                index: 28
                elements:
                  numberOfStudies: {index: 29}
                  numberOfParticipants: {index: 30}
                required: [numberOfParticipants, numberOfStudies]
              attributeEstimate:
                mustSupport: true
                index: 31
                slicing:
                  rules: open
                  discriminator:
                  - {path: type, type: value}
                  min: 1
                  slices:
                    confidenceInterval:
                      match:
                        type:
                          coding:
                          - {code: C53324, system: 'http://terminology.hl7.org/CodeSystem/attribute-estimate-type', display: Confidence interval}
                      schema:
                        mustSupport: true
                        _required: true
                        index: 32
                        elements:
                          type:
                            pattern:
                              type: CodeableConcept
                              value:
                                coding:
                                - {code: C53324, system: 'http://terminology.hl7.org/CodeSystem/attribute-estimate-type', display: Confidence interval}
                            index: 33
                            elements:
                              coding:
                                elements:
                                  system: {index: 34}
                                  code: {index: 35}
                                  display: {index: 36}
                                required: [display, system, code]
                          level:
                            mustSupport: true
                            pattern: {type: Decimal, value: 0.95}
                            index: 37
                          range: {short: Confidence interval of the relative effect, mustSupport: true, index: 38}
                        required: [range, level, type]
            required: [attributeEstimate, quantity, sampleSize, statisticType, description]
        baselineRisk:
          match:
            statisticType:
              coding:
              - {code: C16726, system: 'http://terminology.hl7.org/CodeSystem/statistic-type', display: Incidence}
          schema:
            mustSupport: true
            index: 39
            elements:
              description:
                pattern: {type: Markdown, value: Baseline risk/result in the comparison group}
                index: 40
              statisticType:
                mustSupport: true
                pattern:
                  type: CodeableConcept
                  value:
                    coding:
                    - {code: C16726, system: 'http://terminology.hl7.org/CodeSystem/statistic-type', display: Incidence}
                index: 41
              quantity:
                short: Baseline risk of the presented evidence (intervention vs. comparator) for dichotomous outcomes
                mustSupport: true
                index: 42
                elements:
                  system:
                    pattern: {type: Uri, value: 'http://unitsofmeasure.org'}
                    index: 43
                  code:
                    pattern: {type: Code, value: 1/1000}
                    index: 44
                required: [system, code]
            required: [quantity, statisticType, description]
        meanDifference:
          match: {statisticType: null}
          schema:
            mustSupport: true
            index: 45
            elements:
              description:
                pattern: {type: Markdown, value: Difference intervention vs. comparator}
                index: 46
              statisticType:
                binding: {strength: required, valueSet: 'https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/ValueSet/vs-mean-difference-type'}
                mustSupport: true
                index: 47
              quantity: {short: Difference intervention vs. comparator for continous outcomes, mustSupport: true, index: 48}
              attributeEstimate:
                mustSupport: true
                index: 49
                slicing:
                  rules: open
                  discriminator:
                  - {path: type, type: value}
                  min: 1
                  slices:
                    confidenceInterval:
                      match:
                        type:
                          coding:
                          - {code: C53324, system: 'http://terminology.hl7.org/CodeSystem/attribute-estimate-type', display: Confidence interval}
                      schema:
                        mustSupport: true
                        _required: true
                        index: 50
                        elements:
                          type:
                            pattern:
                              type: CodeableConcept
                              value:
                                coding:
                                - {code: C53324, system: 'http://terminology.hl7.org/CodeSystem/attribute-estimate-type', display: Confidence interval}
                            index: 51
                            elements:
                              coding:
                                elements:
                                  system: {index: 52}
                                  code: {index: 53}
                                  display: {index: 54}
                                required: [display, system, code]
                          level:
                            mustSupport: true
                            pattern: {type: Decimal, value: 0.95}
                            index: 55
                          range: {short: Confidence interval of the relative effect, mustSupport: true, index: 56}
                        required: [range, level, type]
            required: [attributeEstimate, quantity, statisticType, description]
package_version: universitaetsmedizin.ebm-cpg-0.7.0
class: profile
kind: resource
url: https://www.netzwerk-universitaetsmedizin.de/fhir/cpg-on-ebm-on-fhir/StructureDefinition/outcome-evidence
base: http://hl7.org/fhir/StructureDefinition/Evidence
version: 0.2.0
required: [relatedArtifact, name, synthesisType]