{ "description": "Immunhistorchemistry report", "_filename": "StructureDefinition-mii-pr-mtb-immunohistochemistry-mmr.json", "package_name": "de.medizininformatikinitiative.kerndatensatz.mtb", "date": null, "derivation": "constraint", "publisher": "Medizininformatik Initiative", "fhirVersion": "4.0.1", "name": "MII_PR_MTB_Immunohistochemistry_MMR", "abstract": false, "type": "Observation", "experimental": null, "resourceType": "StructureDefinition", "title": "MII PR MTB Immunohistochemistry Mismatch Repair Status", "package_version": "2025.0.0-ballot", "status": "draft", "id": "38ec0799-2b1e-4c13-9faf-f3f9b2e97cf6", "kind": "resource", "url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry-mmr", "version": "2024.0.0-ballot", "differential": { "element": [ { "id": "Observation.identifier", "path": "Observation.identifier", "mustSupport": true }, { "id": "Observation.value[x]", "path": "Observation.value[x]", "slicing": { "rules": "open", "ordered": false, "discriminator": [ { "path": "$this", "type": "type" } ] }, "mustSupport": true }, { "id": "Observation.value[x]:valueCodeableConcept", "max": "1", "min": 0, "path": "Observation.value[x]", "type": [ { "code": "CodeableConcept" } ], "binding": { "strength": "required", "valueSet": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/ValueSet/mii-vs-mtb-mmr-proficiency" }, "sliceName": "valueCodeableConcept", "mustSupport": true }, { "id": "Observation.specimen", "path": "Observation.specimen", "short": "Probe", "definition": "Probe", "mustSupport": true }, { "id": "Observation.component", "path": "Observation.component", "slicing": { "rules": "open", "ordered": false, "description": "Immunohistochemische Ergebnisse", "discriminator": [ { "path": "code", "type": "value" } ] } }, { "id": "Observation.component:mmr-mlh1", "max": "1", "min": 0, "path": "Observation.component", "sliceName": "mmr-mlh1", "mustSupport": true }, { "id": "Observation.component:mmr-mlh1.code.coding", "path": "Observation.component.code.coding", "patternCoding": { "code": "81691-8", "system": "http://loinc.org", "display": "DNA mismatch repair protein Mlh1 [Presence] in Cancer specimen by Immune stain" } }, { "id": "Observation.component:mmr-mlh1.value[x]", "path": "Observation.component.value[x]", "slicing": { "rules": "open", "ordered": false, "discriminator": [ { "path": "$this", "type": "type" } ] } }, { "id": "Observation.component:mmr-mlh1.value[x]:valueCodeableConcept", "max": "1", "min": 0, "path": "Observation.component.value[x]", "type": [ { "code": "CodeableConcept" } ], "sliceName": "valueCodeableConcept" }, { "id": "Observation.component:mmr-mlh1.value[x]:valueCodeableConcept.coding", "path": "Observation.component.value[x].coding", "binding": { "strength": "required", "valueSet": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/ValueSet/mii-vs-mtb-mmr-expression" } }, { "id": "Observation.component:mmr-msh2", "max": "1", "min": 0, "path": "Observation.component", "sliceName": "mmr-msh2", "mustSupport": true }, { "id": "Observation.component:mmr-msh2.code.coding", "path": "Observation.component.code.coding", "patternCoding": { "code": "81692-6", "system": "http://loinc.org", "display": "DNA mismatch repair protein Msh2 [Presence] in Cancer specimen by Immune stain" } }, { "id": "Observation.component:mmr-msh2.value[x]", "path": "Observation.component.value[x]", "slicing": { "rules": "open", "ordered": false, "discriminator": [ { "path": "$this", "type": "type" } ] } }, { "id": "Observation.component:mmr-msh2.value[x]:valueCodeableConcept", "max": "1", "min": 0, "path": "Observation.component.value[x]", "type": [ { "code": "CodeableConcept" } ], "sliceName": "valueCodeableConcept" }, { "id": "Observation.component:mmr-msh2.value[x]:valueCodeableConcept.coding", "path": "Observation.component.value[x].coding", "binding": { "strength": "required", "valueSet": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/ValueSet/mii-vs-mtb-mmr-expression" } }, { "id": "Observation.component:mmr-msh6", "max": "1", "min": 0, "path": "Observation.component", "sliceName": "mmr-msh6", "mustSupport": true }, { "id": "Observation.component:mmr-msh6.code.coding", "path": "Observation.component.code.coding", "patternCoding": { "code": "81693-4", "system": "http://loinc.org", "display": "DNA mismatch repair protein Msh6 [Presence] in Cancer specimen by Immune stain" } }, { "id": "Observation.component:mmr-msh6.value[x]", "path": "Observation.component.value[x]", "slicing": { "rules": "open", "ordered": false, "discriminator": [ { "path": "$this", "type": "type" } ] } }, { "id": "Observation.component:mmr-msh6.value[x]:valueCodeableConcept", "max": "1", "min": 0, "path": "Observation.component.value[x]", "type": [ { "code": "CodeableConcept" } ], "sliceName": "valueCodeableConcept" }, { "id": "Observation.component:mmr-msh6.value[x]:valueCodeableConcept.coding", "path": "Observation.component.value[x].coding", "binding": { "strength": "required", "valueSet": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/ValueSet/mii-vs-mtb-mmr-expression" } }, { "id": "Observation.component:mmr-pms2", "max": "1", "min": 0, "path": "Observation.component", "sliceName": "mmr-pms2", "mustSupport": true }, { "id": "Observation.component:mmr-pms2.code.coding", "path": "Observation.component.code.coding", "patternCoding": { "code": "81694-2", "system": "http://loinc.org", "display": "Mismatch repair endonuclease PMS2 [Presence] in Cancer specimen by Immune stain" } }, { "id": "Observation.component:mmr-pms2.value[x]", "path": "Observation.component.value[x]", "slicing": { "rules": "open", "ordered": false, "discriminator": [ { "path": "$this", "type": "type" } ] } }, { "id": "Observation.component:mmr-pms2.value[x]:valueCodeableConcept", "max": "1", "min": 0, "path": "Observation.component.value[x]", "type": [ { "code": "CodeableConcept" } ], "sliceName": "valueCodeableConcept" }, { "id": "Observation.component:mmr-pms2.value[x]:valueCodeableConcept.coding", "path": "Observation.component.value[x].coding", "binding": { "strength": "required", "valueSet": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/ValueSet/mii-vs-mtb-mmr-expression" } }, { "id": "Observation.component:mmr-msh3", "max": "1", "min": 0, "path": "Observation.component", "sliceName": "mmr-msh3", "mustSupport": true }, { "id": "Observation.component:mmr-msh3.code.coding", "path": "Observation.component.code.coding", "patternCoding": { "code": "96271-2", "system": "http://loinc.org", "display": "DNA mismatch repair protein Msh3 [Presence] in Cancer specimen by Immune stain" } }, { "id": "Observation.component:mmr-msh3.value[x]", "path": "Observation.component.value[x]", "slicing": { "rules": "open", "ordered": false, "discriminator": [ { "path": "$this", "type": "type" } ] } }, { "id": "Observation.component:mmr-msh3.value[x]:valueCodeableConcept", "max": "1", "min": 0, "path": "Observation.component.value[x]", "type": [ { "code": "CodeableConcept" } ], "sliceName": "valueCodeableConcept" }, { "id": "Observation.component:mmr-msh3.value[x]:valueCodeableConcept.coding", "path": "Observation.component.value[x].coding", "binding": { "strength": "required", "valueSet": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/ValueSet/mii-vs-mtb-mmr-expression" } }, { "id": "Observation.component:mmr-mlh3", "max": "1", "min": 0, "path": "Observation.component", "sliceName": "mmr-mlh3", "mustSupport": true }, { "id": "Observation.component:mmr-mlh3.code.coding", "path": "Observation.component.code.coding", "patternCoding": { "code": "96272-0", "system": "http://loinc.org", "display": "DNA mismatch repair protein Mlh3 [Presence] in Cancer specimen by Immune stain" } }, { "id": "Observation.component:mmr-mlh3.value[x]", "path": "Observation.component.value[x]", "slicing": { "rules": "open", "ordered": false, "discriminator": [ { "path": "$this", "type": "type" } ] } }, { "id": "Observation.component:mmr-mlh3.value[x]:valueCodeableConcept", "max": "1", "min": 0, "path": "Observation.component.value[x]", "type": [ { "code": "CodeableConcept" } ], "sliceName": "valueCodeableConcept" }, { "id": "Observation.component:mmr-mlh3.value[x]:valueCodeableConcept.coding", "path": "Observation.component.value[x].coding", "binding": { "strength": "required", "valueSet": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/ValueSet/mii-vs-mtb-mmr-expression" } } ] }, "contact": [ { "telecom": [ { "value": "https://www.medizininformatik-initiative.de", "system": "url" } ] } ], "baseDefinition": "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-molekularer-biomarker" }