description: Immunhistorchemistry report
package_name: de.medizininformatikinitiative.kerndatensatz.mtb
derivation: constraint
name: MII_PR_MTB_Immunohistochemistry_MMR
type: Observation
elements:
  identifier: {mustSupport: true, index: 0}
  value:
    mustSupport: true
    choices: []
    index: 2
    slicing:
      rules: open
      ordered: false
      discriminator:
      - {path: $this, type: type}
      min: null
      slices:
        valueCodeableConcept:
          match: {}
          schema:
            mustSupport: true
            choices: [valueCodeableConcept]
            index: 4
          min: 0
          max: 1
  valueCodeableConcept:
    type: CodeableConcept
    mustSupport: true
    choiceOf: value
    index: 5
    slicing:
      slices:
        valueCodeableConcept:
          match: {}
          schema: {type: CodeableConcept, mustSupport: true, choiceOf: value, index: 5}
          min: 0
          max: 1
  specimen: {short: Probe, mustSupport: true, index: 6}
  component:
    index: 7
    slicing:
      rules: open
      ordered: false
      description: Immunohistochemische Ergebnisse
      discriminator:
      - {path: code, type: value}
      min: null
      slices:
        mmr-mlh1:
          match: {code: null}
          schema:
            mustSupport: true
            index: 8
            elements:
              code:
                elements:
                  coding:
                    pattern:
                      type: Coding
                      value: {code: 81691-8, system: 'http://loinc.org', display: 'DNA mismatch repair protein Mlh1 [Presence] in Cancer specimen by Immune stain'}
                    type: Coding
                    index: 9
              value:
                choices: []
                index: 11
                slicing:
                  rules: open
                  ordered: false
                  discriminator:
                  - {path: $this, type: type}
                  min: null
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema:
                        choices: [valueCodeableConcept]
                        index: 13
                      min: 0
                      max: 1
              valueCodeableConcept:
                type: CodeableConcept
                choiceOf: value
                index: 14
                slicing:
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema: {type: CodeableConcept, choiceOf: value, index: 14}
                      min: 0
                      max: 1
              value[x]:
                elements:
                  coding:
                    binding: {strength: required, valueSet: 'https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/ValueSet/mii-vs-mtb-mmr-expression'}
                    index: 15
        mmr-msh2:
          match: {code: null}
          schema:
            mustSupport: true
            index: 16
            elements:
              code:
                elements:
                  coding:
                    pattern:
                      type: Coding
                      value: {code: 81692-6, system: 'http://loinc.org', display: 'DNA mismatch repair protein Msh2 [Presence] in Cancer specimen by Immune stain'}
                    type: Coding
                    index: 17
              value:
                choices: []
                index: 19
                slicing:
                  rules: open
                  ordered: false
                  discriminator:
                  - {path: $this, type: type}
                  min: null
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema:
                        choices: [valueCodeableConcept]
                        index: 21
                      min: 0
                      max: 1
              valueCodeableConcept:
                type: CodeableConcept
                choiceOf: value
                index: 22
                slicing:
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema: {type: CodeableConcept, choiceOf: value, index: 22}
                      min: 0
                      max: 1
              value[x]:
                elements:
                  coding:
                    binding: {strength: required, valueSet: 'https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/ValueSet/mii-vs-mtb-mmr-expression'}
                    index: 23
        mmr-msh6:
          match: {code: null}
          schema:
            mustSupport: true
            index: 24
            elements:
              code:
                elements:
                  coding:
                    pattern:
                      type: Coding
                      value: {code: 81693-4, system: 'http://loinc.org', display: 'DNA mismatch repair protein Msh6 [Presence] in Cancer specimen by Immune stain'}
                    type: Coding
                    index: 25
              value:
                choices: []
                index: 27
                slicing:
                  rules: open
                  ordered: false
                  discriminator:
                  - {path: $this, type: type}
                  min: null
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema:
                        choices: [valueCodeableConcept]
                        index: 29
                      min: 0
                      max: 1
              valueCodeableConcept:
                type: CodeableConcept
                choiceOf: value
                index: 30
                slicing:
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema: {type: CodeableConcept, choiceOf: value, index: 30}
                      min: 0
                      max: 1
              value[x]:
                elements:
                  coding:
                    binding: {strength: required, valueSet: 'https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/ValueSet/mii-vs-mtb-mmr-expression'}
                    index: 31
        mmr-pms2:
          match: {code: null}
          schema:
            mustSupport: true
            index: 32
            elements:
              code:
                elements:
                  coding:
                    pattern:
                      type: Coding
                      value: {code: 81694-2, system: 'http://loinc.org', display: 'Mismatch repair endonuclease PMS2 [Presence] in Cancer specimen by Immune stain'}
                    type: Coding
                    index: 33
              value:
                choices: []
                index: 35
                slicing:
                  rules: open
                  ordered: false
                  discriminator:
                  - {path: $this, type: type}
                  min: null
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema:
                        choices: [valueCodeableConcept]
                        index: 37
                      min: 0
                      max: 1
              valueCodeableConcept:
                type: CodeableConcept
                choiceOf: value
                index: 38
                slicing:
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema: {type: CodeableConcept, choiceOf: value, index: 38}
                      min: 0
                      max: 1
              value[x]:
                elements:
                  coding:
                    binding: {strength: required, valueSet: 'https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/ValueSet/mii-vs-mtb-mmr-expression'}
                    index: 39
        mmr-msh3:
          match: {code: null}
          schema:
            mustSupport: true
            index: 40
            elements:
              code:
                elements:
                  coding:
                    pattern:
                      type: Coding
                      value: {code: 96271-2, system: 'http://loinc.org', display: 'DNA mismatch repair protein Msh3 [Presence] in Cancer specimen by Immune stain'}
                    type: Coding
                    index: 41
              value:
                choices: []
                index: 43
                slicing:
                  rules: open
                  ordered: false
                  discriminator:
                  - {path: $this, type: type}
                  min: null
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema:
                        choices: [valueCodeableConcept]
                        index: 45
                      min: 0
                      max: 1
              valueCodeableConcept:
                type: CodeableConcept
                choiceOf: value
                index: 46
                slicing:
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema: {type: CodeableConcept, choiceOf: value, index: 46}
                      min: 0
                      max: 1
              value[x]:
                elements:
                  coding:
                    binding: {strength: required, valueSet: 'https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/ValueSet/mii-vs-mtb-mmr-expression'}
                    index: 47
        mmr-mlh3:
          match: {code: null}
          schema:
            mustSupport: true
            index: 48
            elements:
              code:
                elements:
                  coding:
                    pattern:
                      type: Coding
                      value: {code: 96272-0, system: 'http://loinc.org', display: 'DNA mismatch repair protein Mlh3 [Presence] in Cancer specimen by Immune stain'}
                    type: Coding
                    index: 49
              value:
                choices: []
                index: 51
                slicing:
                  rules: open
                  ordered: false
                  discriminator:
                  - {path: $this, type: type}
                  min: null
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema:
                        choices: [valueCodeableConcept]
                        index: 53
                      min: 0
                      max: 1
              valueCodeableConcept:
                type: CodeableConcept
                choiceOf: value
                index: 54
                slicing:
                  slices:
                    valueCodeableConcept:
                      match: {}
                      schema: {type: CodeableConcept, choiceOf: value, index: 54}
                      min: 0
                      max: 1
              value[x]:
                elements:
                  coding:
                    binding: {strength: required, valueSet: 'https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/ValueSet/mii-vs-mtb-mmr-expression'}
                    index: 55
package_version: 2025.0.0-ballot
class: profile
kind: resource
url: https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-immunohistochemistry-mmr
base: https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-molekularer-biomarker
version: 2024.0.0-ballot