{
  "description": "Dieses Profil beschreibt molekulare Biomarker, z.B. genübergreifende Biomarker wie Tumormutationslast (TMB) oder Mikrosatelliteninstabilität (MSI). Es ist ein abstraktes Profil, konkrete Biomarker-Profile erben davon.",
  "_filename": "fsh-generated/resources/StructureDefinition-mii-pr-molgen-molekularer-biomarker.json",
  "package_name": "de.medizininformatikinitiative.kerndatensatz.molgen",
  "date": null,
  "derivation": "constraint",
  "publisher": "Medizininformatik Initiative",
  "fhirVersion": "4.0.1",
  "name": "MII_PR_MolGen_MolekularerBiomarker",
  "abstract": false,
  "type": "Observation",
  "experimental": null,
  "resourceType": "StructureDefinition",
  "title": "MII PR MolGen Molekulare Biomarker",
  "package_version": "2026.0.1",
  "status": "active",
  "id": "1e06898f-988c-4c10-ae44-1a20adb8c23d",
  "kind": "resource",
  "url": "https://www.medizininformatik-initiative.de/fhir/ext/modul-molgen/StructureDefinition/mii-pr-molgen-molekularer-biomarker",
  "version": "2026.0.1",
  "differential": {
    "element": [ {
      "id": "Observation.category",
      "path": "Observation.category",
      "short": "Kategorie",
      "_short": {
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/translation",
          "extension": [ {
            "url": "lang",
            "valueCode": "de-DE"
          }, {
            "url": "content",
            "valueString": "Kategorie"
          } ]
        } ]
      },
      "definition": "Klassifizierung der Beobachtungsart",
      "_definition": {
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/translation",
          "extension": [ {
            "url": "lang",
            "valueCode": "de-DE"
          }, {
            "url": "content",
            "valueString": "Klassifizierung der Beobachtungsart"
          } ]
        } ]
      },
      "mustSupport": true
    }, {
      "id": "Observation.code",
      "path": "Observation.code",
      "short": "Code",
      "_short": {
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/translation",
          "extension": [ {
            "url": "lang",
            "valueCode": "de-DE"
          }, {
            "url": "content",
            "valueString": "Code"
          } ]
        } ]
      },
      "definition": "Code zur Identifizierung des Biomarkers",
      "_definition": {
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/translation",
          "extension": [ {
            "url": "lang",
            "valueCode": "de-DE"
          }, {
            "url": "content",
            "valueString": "Code zur Identifizierung des Biomarkers"
          } ]
        } ]
      },
      "mustSupport": true
    }, {
      "id": "Observation.subject",
      "path": "Observation.subject",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "http://hl7.org/fhir/StructureDefinition/Patient", "http://hl7.org/fhir/StructureDefinition/Group" ]
      } ],
      "short": "Patient",
      "_short": {
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/translation",
          "extension": [ {
            "url": "lang",
            "valueCode": "de-DE"
          }, {
            "url": "content",
            "valueString": "Patient"
          } ]
        } ]
      },
      "definition": "Der Patient auf den sich die Beobachtung bezieht",
      "_definition": {
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/translation",
          "extension": [ {
            "url": "lang",
            "valueCode": "de-DE"
          }, {
            "url": "content",
            "valueString": "Der Patient auf den sich die Beobachtung bezieht"
          } ]
        } ]
      },
      "mustSupport": true
    }, {
      "id": "Observation.encounter",
      "path": "Observation.encounter",
      "short": "Kontakt",
      "_short": {
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/translation",
          "extension": [ {
            "url": "lang",
            "valueCode": "de-DE"
          }, {
            "url": "content",
            "valueString": "Kontakt"
          } ]
        } ]
      },
      "definition": "Der Kontakt in dessen Rahmen die Beobachtung gemacht wurde",
      "_definition": {
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/translation",
          "extension": [ {
            "url": "lang",
            "valueCode": "de-DE"
          }, {
            "url": "content",
            "valueString": "Der Kontakt in dessen Rahmen die Beobachtung gemacht wurde"
          } ]
        } ]
      },
      "mustSupport": true
    }, {
      "id": "Observation.effective[x]",
      "path": "Observation.effective[x]",
      "short": "Zeitpunkt der Beobachtung",
      "_short": {
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/translation",
          "extension": [ {
            "url": "lang",
            "valueCode": "de-DE"
          }, {
            "url": "content",
            "valueString": "Zeitpunkt der Beobachtung"
          } ]
        } ]
      },
      "definition": "Klinisch relevanter Zeitpunkt der Beobachtung",
      "_definition": {
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/translation",
          "extension": [ {
            "url": "lang",
            "valueCode": "de-DE"
          }, {
            "url": "content",
            "valueString": "Klinisch relevanter Zeitpunkt der Beobachtung"
          } ]
        } ]
      },
      "mustSupport": true
    }, {
      "id": "Observation.issued",
      "path": "Observation.issued",
      "short": "Freigabedatum",
      "_short": {
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/translation",
          "extension": [ {
            "url": "lang",
            "valueCode": "de-DE"
          }, {
            "url": "content",
            "valueString": "Freigabedatum"
          } ]
        } ]
      },
      "definition": "Datum und Uhrzeit der Freigabe",
      "_definition": {
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/translation",
          "extension": [ {
            "url": "lang",
            "valueCode": "de-DE"
          }, {
            "url": "content",
            "valueString": "Datum und Uhrzeit der Freigabe"
          } ]
        } ]
      },
      "mustSupport": true
    }, {
      "id": "Observation.derivedFrom",
      "path": "Observation.derivedFrom",
      "short": "Abgeleitet von",
      "_short": {
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/translation",
          "extension": [ {
            "url": "lang",
            "valueCode": "de-DE"
          }, {
            "url": "content",
            "valueString": "Abgeleitet von"
          } ]
        } ]
      },
      "definition": "Referenzen zu anderen Beobachtungen von denen diese abgeleitet ist",
      "_definition": {
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/translation",
          "extension": [ {
            "url": "lang",
            "valueCode": "de-DE"
          }, {
            "url": "content",
            "valueString": "Referenzen zu anderen Beobachtungen von denen diese abgeleitet ist"
          } ]
        } ]
      },
      "mustSupport": true
    }, {
      "id": "Observation.derivedFrom:variant",
      "path": "Observation.derivedFrom",
      "type": [ {
        "code": "Reference",
        "targetProfile": [ "https://www.medizininformatik-initiative.de/fhir/ext/modul-molgen/StructureDefinition/variante" ]
      } ],
      "sliceName": "variant"
    }, {
      "id": "Observation.component",
      "path": "Observation.component",
      "short": "Komponenten",
      "_short": {
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/translation",
          "extension": [ {
            "url": "lang",
            "valueCode": "de-DE"
          }, {
            "url": "content",
            "valueString": "Komponenten"
          } ]
        } ]
      },
      "definition": "Einzelne Komponenten der Beobachtung",
      "_definition": {
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/translation",
          "extension": [ {
            "url": "lang",
            "valueCode": "de-DE"
          }, {
            "url": "content",
            "valueString": "Einzelne Komponenten der Beobachtung"
          } ]
        } ]
      },
      "mustSupport": true
    }, {
      "id": "Observation.component:gene-studied",
      "path": "Observation.component",
      "short": "Untersuchtes Gen",
      "_short": {
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/translation",
          "extension": [ {
            "url": "lang",
            "valueCode": "de-DE"
          }, {
            "url": "content",
            "valueString": "Untersuchtes Gen"
          } ]
        } ]
      },
      "sliceName": "gene-studied",
      "definition": "Das untersuchte Gen",
      "_definition": {
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/translation",
          "extension": [ {
            "url": "lang",
            "valueCode": "de-DE"
          }, {
            "url": "content",
            "valueString": "Das untersuchte Gen"
          } ]
        } ]
      },
      "mustSupport": true
    }, {
      "id": "Observation.component:biomarker-category",
      "path": "Observation.component",
      "short": "Biomarker-Kategorie",
      "_short": {
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/translation",
          "extension": [ {
            "url": "lang",
            "valueCode": "de-DE"
          }, {
            "url": "content",
            "valueString": "Biomarker-Kategorie"
          } ]
        } ]
      },
      "sliceName": "biomarker-category",
      "definition": "Die Kategorie des molekularen Biomarkers",
      "_definition": {
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/translation",
          "extension": [ {
            "url": "lang",
            "valueCode": "de-DE"
          }, {
            "url": "content",
            "valueString": "Die Kategorie des molekularen Biomarkers"
          } ]
        } ]
      },
      "mustSupport": true
    } ]
  },
  "contact": [ {
    "telecom": [ {
      "value": "https://www.medizininformatik-initiative.de",
      "system": "url"
    } ]
  } ],
  "baseDefinition": "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-biomarker"
}