{
  "description": "Gibt an, wie das Medikament eingenommen oder verabreicht wurde bzw. eingenommen oder verabreicht werden soll - entweder selbst vom Patienten eingenommen oder bei Fremdverabreichung von Dritten (z. B. Leistungserbringer, Angehörige) verabreicht.",
  "_filename": "StructureDefinition-DosageDE.json",
  "package_name": "de.fhir.medication",
  "date": "2026-08-30T11:32:01+02:00",
  "derivation": "constraint",
  "publisher": "HL7 Deutschland e.V.",
  "fhirVersion": "4.0.1",
  "name": "DosageDE",
  "mapping": [ {
    "uri": "http://hl7.org/v3",
    "name": "RIM Mapping",
    "identity": "rim"
  }, {
    "uri": "http://hl7.org/v2",
    "name": "HL7 v2 Mapping",
    "identity": "v2"
  } ],
  "abstract": false,
  "type": "Dosage",
  "experimental": null,
  "resourceType": "StructureDefinition",
  "title": "Dosage DE",
  "package_version": "2.0.0-ballot",
  "snapshot": {
    "element": [ {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "DosageStructuredOrFreeTextWarning",
        "human": "A dosage must be given either as free text only or as complete structured information only; mixing both is not allowed.",
        "source": "http://ig.fhir.de/igs/medication/StructureDefinition/DosageDE",
        "severity": "warning",
        "expression": "(%resource.ofType(MedicationRequest).dosageInstruction | \n %resource.ofType(MedicationDispense).dosageInstruction | \n %resource.ofType(MedicationStatement).dosage).all(\n  (text.exists() and timing.empty() and doseAndRate.empty()) or\n  (text.empty() and (timing.exists() or doseAndRate.exists()))\n)"
      }, {
        "key": "DosageStructuredRequiresBothWarning",
        "human": "If a structured dosage is given, both timing and doseAndRate should be present. For pure as-needed dosages, doseAndRate may be given without timing.",
        "source": "http://ig.fhir.de/igs/medication/StructureDefinition/DosageDE",
        "severity": "warning",
        "expression": "(%resource.ofType(MedicationRequest).dosageInstruction | \n %resource.ofType(MedicationDispense).dosageInstruction | \n %resource.ofType(MedicationStatement).dosage).all(\n  (timing.exists() implies doseAndRate.exists()) and\n  (doseAndRate.exists() implies (\n    timing.exists() or\n    asNeeded.ofType(boolean) = true or\n    extension.where(url='http://hl7.org/fhir/5.0/StructureDefinition/extension-Dosage.asNeededFor').exists()\n  ))\n)"
      }, {
        "key": "DosageDoseUnitSameCodeWarning",
        "human": "The dose unit should be the same across all dosages.",
        "source": "http://ig.fhir.de/igs/medication/StructureDefinition/DosageDE",
        "severity": "warning",
        "expression": "(%resource.ofType(MedicationRequest).dosageInstruction | %resource.ofType(MedicationDispense).dosageInstruction | %resource.ofType(MedicationStatement).dosage).all(\ndoseAndRate.exists() implies\n  (\n    (%resource.ofType(MedicationRequest).dosageInstruction | %resource.ofType(MedicationDispense).dosageInstruction | %resource.ofType(MedicationStatement).dosage).doseAndRate.dose.ofType(Quantity).code | \n    (%resource.ofType(MedicationRequest).dosageInstruction | %resource.ofType(MedicationDispense).dosageInstruction | %resource.ofType(MedicationStatement).dosage).doseAndRate.dose.ofType(Range).low.code | \n    (%resource.ofType(MedicationRequest).dosageInstruction | %resource.ofType(MedicationDispense).dosageInstruction | %resource.ofType(MedicationStatement).dosage).doseAndRate.dose.ofType(Range).high.code\n  ).distinct().count() = 1\n)"
      }, {
        "key": "DosageDoseValuePositiveWarning",
        "human": "doseQuantity.value and doseRange.high.value should be greater than 0. The value 0 is additionally allowed for doseRange.low.value only.",
        "source": "http://ig.fhir.de/igs/medication/StructureDefinition/DosageDE",
        "severity": "warning",
        "expression": "doseAndRate.all(\n  dose.ofType(Quantity).value.all($this > 0) and\n  dose.ofType(Range).low.value.all($this >= 0) and\n  dose.ofType(Range).high.value.all($this > 0)\n)"
      }, {
        "key": "DosageFourSlotPatternInTextWarning",
        "human": "A four-slot dosing schema (Viererschema, e.g. 1-1-1-1) was detected in Dosage.text. Please check whether it can be represented structurally.",
        "source": "http://ig.fhir.de/igs/medication/StructureDefinition/DosageDE",
        "severity": "warning",
        "expression": "text.exists() implies text.matches('.*\\\\d+\\\\s*[-–]\\\\s*\\\\d+\\\\s*[-–]\\\\s*\\\\d+\\\\s*[-–]\\\\s*\\\\d+.*').not()"
      }, {
        "key": "FreeTextSingleDosageOnlyWarning",
        "human": "If a dosage is given as pure free text, there should be exactly one Dosage element.",
        "source": "http://ig.fhir.de/igs/medication/StructureDefinition/DosageDE",
        "severity": "warning",
        "expression": "(\n  (%resource.ofType(MedicationRequest).dosageInstruction |\n   %resource.ofType(MedicationDispense).dosageInstruction |\n   %resource.ofType(MedicationStatement).dosage\n  ).exists(text.exists() and timing.empty() and doseAndRate.empty())\n)\nimplies\n(\n  (%resource.ofType(MedicationRequest).dosageInstruction |\n   %resource.ofType(MedicationDispense).dosageInstruction |\n   %resource.ofType(MedicationStatement).dosage\n  ).count() = 1\n)"
      }, {
        "key": "dos-1",
        "human": "AsNeededFor can only be set if AsNeeded is empty or true",
        "source": "http://ig.fhir.de/igs/medication/StructureDefinition/DosageDE",
        "severity": "error",
        "expression": "extension.where(url='http://hl7.org/fhir/5.0/StructureDefinition/extension-Dosage.asNeededFor').empty() or asNeeded.empty() or asNeeded"
      } ],
      "path": "Dosage",
      "min": 0,
      "definition": "Indicates how the medication is/was taken or should be taken by the patient.",
      "isModifier": false,
      "short": "How the medication is/was taken or should be taken",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      }, {
        "map": ".outboundRelationship[typeCode=COMP].target[classCode=SBADM, moodCode=INT]",
        "identity": "rim"
      } ],
      "max": "*",
      "id": "Dosage",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Dosage"
      }
    }, {
      "path": "Dosage.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Dosage.id",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "xpath": "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Dosage.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "slicing": {
        "rules": "open",
        "description": "Extensions are always sliced by (at least) url",
        "discriminator": [ {
          "path": "url",
          "type": "value"
        } ]
      },
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Dosage.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "xpath": "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Dosage.extension",
      "min": 0,
      "definition": "Gibt die Indikation für die Bedarfsdosierung an.",
      "isModifier": false,
      "short": "Indikation für die Bedarfsdosierung",
      "type": [ {
        "code": "Extension",
        "profile": [ "http://hl7.org/fhir/5.0/StructureDefinition/extension-Dosage.asNeededFor" ]
      } ],
      "mustSupport": true,
      "sliceName": "asNeededFor",
      "max": "*",
      "id": "Dosage.extension:asNeededFor",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "path": "Dosage.extension.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Dosage.extension:asNeededFor.id",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "xpath": "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Dosage.extension.extension",
      "min": 0,
      "definition": "An Extension",
      "isModifier": false,
      "short": "Extension",
      "slicing": {
        "rules": "open",
        "description": "Extensions are always sliced by (at least) url",
        "discriminator": [ {
          "path": "url",
          "type": "value"
        } ]
      },
      "type": [ {
        "code": "Extension"
      } ],
      "max": "0",
      "id": "Dosage.extension:asNeededFor.extension",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "path": "Dosage.extension.url",
      "min": 1,
      "definition": "Source of the definition for the extension code - a logical name or a URL.",
      "isModifier": false,
      "short": "identifies the meaning of the extension",
      "fixedUri": "http://hl7.org/fhir/5.0/StructureDefinition/extension-Dosage.asNeededFor",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "uri"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Dosage.extension:asNeededFor.url",
      "comment": "The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.",
      "base": {
        "max": "1",
        "min": 1,
        "path": "Extension.url"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.extension.value[x]",
      "min": 0,
      "definition": "Value of extension - must be one of a constrained set of the data types (see [Extensibility](http://hl7.org/fhir/R4/extensibility.html) for a list).",
      "isModifier": false,
      "short": "Value of extension",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "binding": {
        "strength": "example",
        "valueSet": "http://hl7.org/fhir/ValueSet/medication-as-needed-reason"
      },
      "max": "1",
      "id": "Dosage.extension:asNeededFor.value[x]",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Extension.value[x]"
      },
      "isSummary": false
    }, {
      "path": "Dosage.extension.value[x].id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Dosage.extension:asNeededFor.value[x].id",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "xpath": "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Dosage.extension.value[x].extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "slicing": {
        "rules": "open",
        "description": "Extensions are always sliced by (at least) url",
        "discriminator": [ {
          "path": "url",
          "type": "value"
        } ]
      },
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Dosage.extension:asNeededFor.value[x].extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.extension.value[x].coding",
      "requirements": "Allows for alternative encodings within a code system, and translations to other code systems.",
      "min": 0,
      "definition": "A reference to a code defined by a terminology system.",
      "isModifier": false,
      "short": "Code defined by a terminology system",
      "mapping": [ {
        "map": "C*E.1-8, C*E.10-22",
        "identity": "v2"
      }, {
        "map": "union(., ./translation)",
        "identity": "rim"
      }, {
        "map": "fhir:CodeableConcept.coding rdfs:subPropertyOf dt:CD.coding",
        "identity": "orim"
      } ],
      "type": [ {
        "code": "Coding"
      } ],
      "max": "*",
      "id": "Dosage.extension:asNeededFor.value[x].coding",
      "comment": "Codes may be defined very casually in enumerations, or code lists, up to very formal definitions such as SNOMED CT - see the HL7 v3 Core Principles for more information.  Ordering of codings is undefined and SHALL NOT be used to infer meaning. Generally, at most only one of the coding values will be labeled as UserSelected = true.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "CodeableConcept.coding"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.extension.value[x].text",
      "requirements": "The codes from the terminologies do not always capture the correct meaning with all the nuances of the human using them, or sometimes there is no appropriate code at all. In these cases, the text is used to capture the full meaning of the source.",
      "min": 0,
      "definition": "A human language representation of the concept as seen/selected/uttered by the user who entered the data and/or which represents the intended meaning of the user.",
      "isModifier": false,
      "short": "Plain text representation of the concept",
      "mapping": [ {
        "map": "C*E.9. But note many systems use C*E.2 for this",
        "identity": "v2"
      }, {
        "map": "./originalText[mediaType/code=\"text/plain\"]/data",
        "identity": "rim"
      }, {
        "map": "fhir:CodeableConcept.text rdfs:subPropertyOf dt:CD.originalText",
        "identity": "orim"
      } ],
      "type": [ {
        "code": "string"
      } ],
      "mustSupport": true,
      "extension": [ {
        "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
        "valueBoolean": true
      } ],
      "max": "1",
      "id": "Dosage.extension:asNeededFor.value[x].text",
      "comment": "Very often the text is the same as a displayName of one of the codings.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "CodeableConcept.text"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "xpath": "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Dosage.modifierExtension",
      "min": 0,
      "definition": "An Extension",
      "isModifier": true,
      "short": "Extension",
      "slicing": {
        "rules": "open",
        "ordered": false,
        "discriminator": [ {
          "path": "url",
          "type": "value"
        } ]
      },
      "type": [ {
        "code": "Extension"
      } ],
      "max": "*",
      "id": "Dosage.modifierExtension",
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Modifier extensions are expected to modify the meaning or interpretation of the element that contains them",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "xpath": "exists(f:extension)!=exists(f:*[starts-with(local-name(.), 'value')])",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Dosage.modifierExtension",
      "min": 0,
      "definition": "Gibt den Mindestabstand zwischen zwei Gaben einer Bedarfsmedikation an.",
      "isModifier": true,
      "short": "Mindestabstand zwischen zwei Gaben",
      "type": [ {
        "code": "Extension",
        "profile": [ "http://ig.fhir.de/igs/medication/StructureDefinition/MinimumIntervalBetweenAdministrations" ]
      } ],
      "mustSupport": true,
      "sliceName": "minimumIntervalBetweenAdministrations",
      "max": "1",
      "id": "Dosage.modifierExtension:minimumIntervalBetweenAdministrations",
      "condition": [ "ele-1" ],
      "base": {
        "max": "*",
        "min": 0,
        "path": "BackboneElement.modifierExtension"
      },
      "isModifierReason": "Der Mindestabstand zwischen Gaben verändert die zulässige Interpretation und Anwendung der Dosierung.",
      "isSummary": true
    }, {
      "path": "Dosage.modifierExtension.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Dosage.modifierExtension:minimumIntervalBetweenAdministrations.id",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "xpath": "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Dosage.modifierExtension.extension",
      "min": 0,
      "definition": "An Extension",
      "isModifier": false,
      "short": "Extension",
      "slicing": {
        "rules": "open",
        "description": "Extensions are always sliced by (at least) url",
        "discriminator": [ {
          "path": "url",
          "type": "value"
        } ]
      },
      "type": [ {
        "code": "Extension"
      } ],
      "max": "0",
      "id": "Dosage.modifierExtension:minimumIntervalBetweenAdministrations.extension",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "path": "Dosage.modifierExtension.url",
      "min": 1,
      "definition": "Source of the definition for the extension code - a logical name or a URL.",
      "isModifier": false,
      "short": "identifies the meaning of the extension",
      "fixedUri": "http://ig.fhir.de/igs/medication/StructureDefinition/MinimumIntervalBetweenAdministrations",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "uri"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Dosage.modifierExtension:minimumIntervalBetweenAdministrations.url",
      "comment": "The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.",
      "base": {
        "max": "1",
        "min": 1,
        "path": "Extension.url"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.modifierExtension.value[x]",
      "min": 1,
      "definition": "Zeitlicher Mindestabstand, der zwischen zwei Gaben einer Bedarfsmedikation einzuhalten ist.",
      "isModifier": false,
      "short": "Mindestabstand zwischen zwei Gaben",
      "mapping": [ {
        "map": "N/A",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Duration"
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Dosage.modifierExtension:minimumIntervalBetweenAdministrations.value[x]",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Extension.value[x]"
      },
      "isSummary": false
    }, {
      "path": "Dosage.modifierExtension.value[x].id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Dosage.modifierExtension:minimumIntervalBetweenAdministrations.value[x].id",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "xpath": "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Dosage.modifierExtension.value[x].extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "slicing": {
        "rules": "open",
        "description": "Extensions are always sliced by (at least) url",
        "discriminator": [ {
          "path": "url",
          "type": "value"
        } ]
      },
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Dosage.modifierExtension:minimumIntervalBetweenAdministrations.value[x].extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.modifierExtension.value[x].value",
      "requirements": "Precision is handled implicitly in almost all cases of measurement.",
      "min": 0,
      "definition": "The value of the measured amount. The value includes an implicit precision in the presentation of the value.",
      "isModifier": false,
      "short": "Numerical value (with implicit precision)",
      "mapping": [ {
        "map": "SN.2  / CQ - N/A",
        "identity": "v2"
      }, {
        "map": "PQ.value, CO.value, MO.value, IVL.high or IVL.low depending on the value",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "decimal"
      } ],
      "max": "1",
      "id": "Dosage.modifierExtension:minimumIntervalBetweenAdministrations.value[x].value",
      "comment": "The implicit precision in the value should always be honored. Monetary values have their own rules for handling precision (refer to standard accounting text books).",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.value"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.modifierExtension.value[x].comparator",
      "requirements": "Need a framework for handling measures where the value is <5ug/L or >400mg/L due to the limitations of measuring methodology.",
      "min": 0,
      "definition": "How the value should be understood and represented - whether the actual value is greater or less than the stated value due to measurement issues; e.g. if the comparator is \"<\" , then the real value is < stated value.",
      "isModifier": true,
      "short": "< | <= | >= | > - how to understand the value",
      "mapping": [ {
        "map": "SN.1  / CQ.1",
        "identity": "v2"
      }, {
        "map": "IVL properties",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "code"
      } ],
      "meaningWhenMissing": "If there is no comparator, then there is no modification of the value",
      "binding": {
        "strength": "required",
        "valueSet": "http://hl7.org/fhir/ValueSet/quantity-comparator|4.0.1",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "QuantityComparator"
        } ],
        "description": "How the Quantity should be understood and represented."
      },
      "max": "1",
      "id": "Dosage.modifierExtension:minimumIntervalBetweenAdministrations.value[x].comparator",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.comparator"
      },
      "isModifierReason": "This is labeled as \"Is Modifier\" because the comparator modifies the interpretation of the value significantly. If there is no comparator, then there is no modification of the value",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.modifierExtension.value[x].unit",
      "requirements": "There are many representations for units of measure and in many contexts, particular representations are fixed and required. I.e. mcg for micrograms.",
      "min": 0,
      "definition": "A human-readable form of the unit.",
      "isModifier": false,
      "short": "Unit representation",
      "mapping": [ {
        "map": "(see OBX.6 etc.) / CQ.2",
        "identity": "v2"
      }, {
        "map": "PQ.unit",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "string"
      } ],
      "mustSupport": true,
      "extension": [ {
        "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
        "valueBoolean": true
      } ],
      "max": "1",
      "id": "Dosage.modifierExtension:minimumIntervalBetweenAdministrations.value[x].unit",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.unit"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.modifierExtension.value[x].system",
      "requirements": "Need to know the system that defines the coded form of the unit.",
      "min": 0,
      "definition": "The identification of the system that provides the coded form of the unit.",
      "isModifier": false,
      "short": "System that defines coded unit form",
      "mapping": [ {
        "map": "(see OBX.6 etc.) / CQ.2",
        "identity": "v2"
      }, {
        "map": "CO.codeSystem, PQ.translation.codeSystem",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "uri"
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Dosage.modifierExtension:minimumIntervalBetweenAdministrations.value[x].system",
      "condition": [ "qty-3" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.system"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.modifierExtension.value[x].code",
      "requirements": "Need a computable form of the unit that is fixed across all forms. UCUM provides this for quantities, but SNOMED CT provides many units of interest.",
      "min": 0,
      "definition": "A computer processable form of the unit in some unit representation system.",
      "isModifier": false,
      "short": "Coded form of the unit",
      "mapping": [ {
        "map": "(see OBX.6 etc.) / CQ.2",
        "identity": "v2"
      }, {
        "map": "PQ.code, MO.currency, PQ.translation.code",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "code"
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Dosage.modifierExtension:minimumIntervalBetweenAdministrations.value[x].code",
      "comment": "The preferred system is UCUM, but SNOMED CT can also be used (for customary units) or ISO 4217 for currency.  The context of use may additionally require a code from a particular system.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.code"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.sequence",
      "requirements": "If the sequence number of multiple Dosages is the same, then it is implied that the instructions are to be treated as concurrent.  If the sequence number is different, then the Dosages are intended to be sequential.",
      "min": 0,
      "definition": "Indicates the order in which the dosage instructions should be applied or interpreted.",
      "isModifier": false,
      "short": "The order of the dosage instructions",
      "mapping": [ {
        "map": "TQ1-1",
        "identity": "v2"
      }, {
        "map": ".text",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "integer"
      } ],
      "max": "1",
      "id": "Dosage.sequence",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Dosage.sequence"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.text",
      "requirements": "Free text dosage instructions can be used for cases where the instructions are too complex to code.  The content of this attribute does not include the name or description of the medication. When coded instructions are present, the free text instructions may still be present for display to humans taking or administering the medication. It is expected that the text instructions will always be populated.  If the dosage.timing attribute is also populated, then the dosage.text should reflect the same information as the timing.  Additional information about administration or preparation of the medication should be included as text.",
      "min": 0,
      "definition": "Freitext-Dosierungsanweisungen, z. B. 'Maximal 3x täglich 1 Stück bei Bedarf'. Als Quelle dient hier ausschließlich der Arzt oder Apotheker",
      "isModifier": false,
      "short": "Freitext-Dosierungsanweisungen, z. B. 'Maximal 3x täglich 1 Stück bei Bedarf'",
      "mapping": [ {
        "map": "RXO-6; RXE-21",
        "identity": "v2"
      }, {
        "map": ".text",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "string"
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Dosage.text",
      "comment": "Die Freitextdosierung sollte nur angegeben werden, wenn aufgrund der Komplexität keine strukturierte Dosierung möglich ist, um widersprüchliche Anweisungen zu vermeiden.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Dosage.text"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.additionalInstruction",
      "requirements": "Additional instruction is intended to be coded, but where no code exists, the element could include text.  For example, \"Swallow with plenty of water\" which might or might not be coded.",
      "min": 0,
      "definition": "Supplemental instructions to the patient on how to take the medication  (e.g. \"with meals\" or\"take half to one hour before food\") or warnings for the patient about the medication (e.g. \"may cause drowsiness\" or \"avoid exposure of skin to direct sunlight or sunlamps\").",
      "isModifier": false,
      "short": "Supplemental instruction or warnings to the patient - e.g. \"with meals\", \"may cause drowsiness\"",
      "mapping": [ {
        "map": "RXO-7",
        "identity": "v2"
      }, {
        "map": ".text",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "binding": {
        "strength": "example",
        "valueSet": "http://hl7.org/fhir/ValueSet/additional-instruction-codes|4.0.1",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "AdditionalInstruction"
        } ],
        "description": "A coded concept identifying additional instructions such as \"take with water\" or \"avoid operating heavy machinery\"."
      },
      "max": "*",
      "id": "Dosage.additionalInstruction",
      "comment": "Information about administration or preparation of the medication (e.g. \"infuse as rapidly as possibly via intraperitoneal port\" or \"immediately following drug x\") should be populated in dosage.text.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Dosage.additionalInstruction"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.patientInstruction",
      "min": 0,
      "definition": "Ergänzende, nicht strukturiert abbildbare Anwendungshinweise für die sichere, korrekte oder verständliche Anwendung des Arzneimittels.",
      "isModifier": false,
      "short": "Ergänzende Anwendungshinweise für Patientinnen und Patienten",
      "mapping": [ {
        "map": "RXO-7",
        "identity": "v2"
      }, {
        "map": ".text",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "string"
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Dosage.patientInstruction",
      "comment": "Dieses Feld dient ausschließlich für zusätzliche Instruktionen, die nicht bereits eindeutig über strukturierte Dosierungsangaben abbildbar sind, z. B. qualitative oder situative Hinweise.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Dosage.patientInstruction"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.timing",
      "requirements": "The timing schedule for giving the medication to the patient. This  data type allows many different expressions. For example: \"Every 8 hours\"; \"Three times a day\"; \"1/2 an hour before breakfast for 10 days from 23-Dec 2011:\"; \"15 Oct 2013, 17 Oct 2013 and 1 Nov 2013\".  Sometimes, a rate can imply duration when expressed as total volume / duration (e.g.  500mL/2 hours implies a duration of 2 hours).  However, when rate doesn't imply duration (e.g. 250mL/hour), then the timing.repeat.duration is needed to convey the infuse over time period.",
      "min": 0,
      "definition": "Wann das Medikament verabreicht werden soll.",
      "isModifier": false,
      "short": "Wann das Medikament verabreicht werden soll",
      "mapping": [ {
        "map": ".effectiveTime",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Timing",
        "profile": [ "http://ig.fhir.de/igs/medication/StructureDefinition/TimingDE" ]
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Dosage.timing",
      "comment": "Um widersprüchliche Anweisungen zu vermeiden, ist entweder Dosage.timing oder Dosage.text zu befüllen. Falls eine strukturierte Dosierung als Text abgebildet werden soll ist dafür die GeneratedDosageInstructionsMeta Extension zu verwenden.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Dosage.timing"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.asNeeded[x]",
      "min": 0,
      "definition": "Gibt an, ob es sich um eine Bedarfsdosierung handelt. Es ist nur eine Ja/Nein-Angabe erlaubt. Die Abbildung der Indikation erfolgt über die Extension asNeededFor.",
      "isModifier": false,
      "short": "Bedarfsdosierung (nur Ja/Nein-Angabe)",
      "mapping": [ {
        "map": "TQ1-9",
        "identity": "v2"
      }, {
        "map": ".outboundRelationship[typeCode=PRCN].target[classCode=OBS, moodCode=EVN, code=\"as needed\"].value=boolean or codable concept",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "boolean"
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Dosage.asNeeded[x]",
      "comment": "Can express \"as needed\" without a reason by setting the Boolean = True.  In this case the CodeableConcept is not populated.  Or you can express \"as needed\" with a reason by including the CodeableConcept.  In this case the Boolean is assumed to be True.  If you set the Boolean to False, then the dose is given according to the schedule and is not \"prn\" or \"as needed\".",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Dosage.asNeeded[x]"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.site",
      "requirements": "A coded specification of the anatomic site where the medication first enters the body.",
      "min": 0,
      "definition": "Body site to administer to.",
      "isModifier": false,
      "short": "Body site to administer to",
      "mapping": [ {
        "map": "RXR-2",
        "identity": "v2"
      }, {
        "map": ".approachSiteCode",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "binding": {
        "strength": "example",
        "valueSet": "http://hl7.org/fhir/ValueSet/approach-site-codes|4.0.1",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "MedicationAdministrationSite"
        } ],
        "description": "A coded concept describing the site location the medicine enters into or onto the body."
      },
      "max": "1",
      "id": "Dosage.site",
      "comment": "If the use case requires attributes from the BodySite resource (e.g. to identify and track separately) then use the standard extension [bodySite](http://hl7.org/fhir/R4/extension-bodysite.html).  May be a summary code, or a reference to a very precise definition of the location, or both.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Dosage.site"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.route",
      "requirements": "A code specifying the route or physiological path of administration of a therapeutic agent into or onto a patient's body.",
      "min": 0,
      "definition": "How drug should enter body.",
      "isModifier": false,
      "short": "How drug should enter body",
      "mapping": [ {
        "map": "RXR-1",
        "identity": "v2"
      }, {
        "map": ".routeCode",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "binding": {
        "strength": "example",
        "valueSet": "http://hl7.org/fhir/ValueSet/route-codes|4.0.1",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "RouteOfAdministration"
        } ],
        "description": "A coded concept describing the route or physiological path of administration of a therapeutic agent into or onto the body of a subject."
      },
      "max": "1",
      "id": "Dosage.route",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Dosage.route"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.method",
      "requirements": "A coded value indicating the method by which the medication is introduced into or onto the body. Most commonly used for injections.  For examples, Slow Push; Deep IV.",
      "min": 0,
      "definition": "Technique for administering medication.",
      "isModifier": false,
      "short": "Technique for administering medication",
      "mapping": [ {
        "map": "RXR-4",
        "identity": "v2"
      }, {
        "map": ".doseQuantity",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "binding": {
        "strength": "example",
        "valueSet": "http://hl7.org/fhir/ValueSet/administration-method-codes|4.0.1",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "MedicationAdministrationMethod"
        } ],
        "description": "A coded concept describing the technique by which the medicine is administered."
      },
      "max": "1",
      "id": "Dosage.method",
      "comment": "Terminologies used often pre-coordinate this term with the route and or form of administration.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Dosage.method"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.doseAndRate",
      "min": 0,
      "definition": "Die verabreichte Menge des Medikaments.",
      "isModifier": false,
      "short": "Menge des verabreichten Medikaments",
      "mapping": [ {
        "map": "TQ1-2",
        "identity": "v2"
      } ],
      "type": [ {
        "code": "Element"
      } ],
      "mustSupport": true,
      "max": "*",
      "id": "Dosage.doseAndRate",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Dosage.doseAndRate"
      },
      "isSummary": true
    }, {
      "path": "Dosage.doseAndRate.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Dosage.doseAndRate.id",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "xpath": "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Dosage.doseAndRate.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "slicing": {
        "rules": "open",
        "description": "Extensions are always sliced by (at least) url",
        "discriminator": [ {
          "path": "url",
          "type": "value"
        } ]
      },
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Dosage.doseAndRate.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.doseAndRate.type",
      "requirements": "If the type is not populated, assume to be \"ordered\".",
      "min": 0,
      "definition": "The kind of dose or rate specified, for example, ordered or calculated.",
      "isModifier": false,
      "short": "The kind of dose or rate specified",
      "mapping": [ {
        "map": "RXO-21; RXE-23",
        "identity": "v2"
      } ],
      "type": [ {
        "code": "CodeableConcept"
      } ],
      "binding": {
        "strength": "example",
        "valueSet": "http://hl7.org/fhir/ValueSet/dose-rate-type|4.0.1",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "DoseAndRateType"
        } ],
        "description": "The kind of dose or rate specified."
      },
      "max": "1",
      "id": "Dosage.doseAndRate.type",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Dosage.doseAndRate.type"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.doseAndRate.dose[x]",
      "requirements": "The amount of therapeutic or other substance given at one administration event.",
      "min": 0,
      "definition": "Amount of medication per dose.",
      "isModifier": false,
      "short": "Amount of medication per dose",
      "mapping": [ {
        "map": "RXO-2, RXE-3",
        "identity": "v2"
      }, {
        "map": ".doseQuantity",
        "identity": "rim"
      } ],
      "slicing": {
        "rules": "closed",
        "ordered": false,
        "discriminator": [ {
          "path": "$this",
          "type": "type"
        } ]
      },
      "type": [ {
        "code": "Range"
      }, {
        "code": "Quantity",
        "profile": [ "http://hl7.org/fhir/StructureDefinition/SimpleQuantity|4.0.1" ]
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Dosage.doseAndRate.dose[x]",
      "comment": "Note that this specifies the quantity of the specified medication, not the quantity for each active ingredient(s). Each ingredient amount can be communicated in the Medication resource. For example, if one wants to communicate that a tablet was 375 mg, where the dose was one tablet, you can use the Medication resource to document that the tablet was comprised of 375 mg of drug XYZ. Alternatively if the dose was 375 mg, then you may only need to use the Medication resource to indicate this was a tablet. If the example were an IV such as dopamine and you wanted to communicate that 400mg of dopamine was mixed in 500 ml of some IV solution, then this would all be communicated in the Medication resource. If the administration is not intended to be instantaneous (rate is present or timing has a duration), this can be specified to convey the total amount to be administered over the period of time as indicated by the schedule e.g. 500 ml in dose, with timing used to convey that this should be done over 4 hours.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Dosage.doseAndRate.dose[x]"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.doseAndRate.dose[x]",
      "requirements": "The amount of therapeutic or other substance given at one administration event.",
      "min": 0,
      "definition": "Menge des Medikaments pro Dosis.",
      "isModifier": false,
      "short": "Menge des Medikaments pro Dosis",
      "mapping": [ {
        "map": "RXO-2, RXE-3",
        "identity": "v2"
      }, {
        "map": ".doseQuantity",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Quantity",
        "profile": [ "http://hl7.org/fhir/StructureDefinition/SimpleQuantity" ]
      } ],
      "mustSupport": true,
      "sliceName": "doseQuantity",
      "binding": {
        "strength": "required",
        "valueSet": "http://ig.fhir.de/igs/medication/ValueSet/DosageDoseQuantityDE"
      },
      "max": "1",
      "id": "Dosage.doseAndRate.dose[x]:doseQuantity",
      "comment": "Beachten Sie, dass dies die Menge des angegebenen Medikaments angibt, nicht die Menge für die einzelnen Wirkstoffe. Jede Wirkstoffmenge kann in der Medication-Ressource kommuniziert werden. Zum Beispiel, wenn man angeben möchte, dass eine Tablette 375 mg enthält und die Dosis eine Tablette beträgt, kann man die Medication-Ressource verwenden, um zu dokumentieren, dass die Tablette aus 375 mg des Wirkstoffs XYZ besteht. Alternativ, wenn die Dosis 375 mg beträgt, muss man möglicherweise nur angeben, dass es sich um eine Tablette handelt. Bei einer Infusion wie Dopamin, bei der 400 mg Dopamin in 500 ml einer Infusionslösung gemischt werden, würde dies alles in der Medication-Ressource kommuniziert werden. Wenn die Verabreichung nicht als sofortig vorgesehen ist (Rate ist vorhanden oder Timing hat eine Dauer), kann dies angegeben werden, um die Gesamtmenge anzugeben, die über den im Zeitplan angegebenen Zeitraum verabreicht werden soll, z. B. 500 ml in der Dosis, wobei Timing verwendet wird, um anzugeben, dass dies über 4 Stunden erfolgen soll.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Dosage.doseAndRate.dose[x]"
      },
      "isSummary": true
    }, {
      "path": "Dosage.doseAndRate.dose[x].id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Dosage.doseAndRate.dose[x]:doseQuantity.id",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "xpath": "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Dosage.doseAndRate.dose[x].extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "slicing": {
        "rules": "open",
        "description": "Extensions are always sliced by (at least) url",
        "discriminator": [ {
          "path": "url",
          "type": "value"
        } ]
      },
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Dosage.doseAndRate.dose[x]:doseQuantity.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.doseAndRate.dose[x].value",
      "requirements": "Precision is handled implicitly in almost all cases of measurement.",
      "min": 0,
      "definition": "The value of the measured amount. The value includes an implicit precision in the presentation of the value.",
      "isModifier": false,
      "short": "Numerical value (with implicit precision)",
      "mapping": [ {
        "map": "SN.2  / CQ - N/A",
        "identity": "v2"
      }, {
        "map": "PQ.value, CO.value, MO.value, IVL.high or IVL.low depending on the value",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "decimal"
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Dosage.doseAndRate.dose[x]:doseQuantity.value",
      "comment": "The implicit precision in the value should always be honored. Monetary values have their own rules for handling precision (refer to standard accounting text books).",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.value"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.doseAndRate.dose[x].comparator",
      "requirements": "Need a framework for handling measures where the value is <5ug/L or >400mg/L due to the limitations of measuring methodology.",
      "min": 0,
      "definition": "Not allowed to be used in this context",
      "isModifier": true,
      "short": "< | <= | >= | > - how to understand the value",
      "mapping": [ {
        "map": "SN.1  / CQ.1",
        "identity": "v2"
      }, {
        "map": "IVL properties",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "code"
      } ],
      "meaningWhenMissing": "If there is no comparator, then there is no modification of the value",
      "binding": {
        "strength": "required",
        "valueSet": "http://hl7.org/fhir/ValueSet/quantity-comparator|4.0.1",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "QuantityComparator"
        } ],
        "description": "How the Quantity should be understood and represented."
      },
      "max": "0",
      "id": "Dosage.doseAndRate.dose[x]:doseQuantity.comparator",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.comparator"
      },
      "isModifierReason": "This is labeled as \"Is Modifier\" because the comparator modifies the interpretation of the value significantly. If there is no comparator, then there is no modification of the value",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.doseAndRate.dose[x].unit",
      "requirements": "There are many representations for units of measure and in many contexts, particular representations are fixed and required. I.e. mcg for micrograms.",
      "min": 0,
      "definition": "A human-readable form of the unit.",
      "isModifier": false,
      "short": "Unit representation",
      "mapping": [ {
        "map": "(see OBX.6 etc.) / CQ.2",
        "identity": "v2"
      }, {
        "map": "PQ.unit",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "string"
      } ],
      "mustSupport": true,
      "extension": [ {
        "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
        "valueBoolean": true
      } ],
      "max": "1",
      "id": "Dosage.doseAndRate.dose[x]:doseQuantity.unit",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.unit"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.doseAndRate.dose[x].system",
      "requirements": "Need to know the system that defines the coded form of the unit.",
      "min": 0,
      "definition": "The identification of the system that provides the coded form of the unit.",
      "isModifier": false,
      "short": "System that defines coded unit form",
      "mapping": [ {
        "map": "(see OBX.6 etc.) / CQ.2",
        "identity": "v2"
      }, {
        "map": "CO.codeSystem, PQ.translation.codeSystem",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "uri"
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Dosage.doseAndRate.dose[x]:doseQuantity.system",
      "condition": [ "qty-3" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.system"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.doseAndRate.dose[x].code",
      "requirements": "Need a computable form of the unit that is fixed across all forms. UCUM provides this for quantities, but SNOMED CT provides many units of interest.",
      "min": 0,
      "definition": "A computer processable form of the unit in some unit representation system.",
      "isModifier": false,
      "short": "Coded form of the unit",
      "mapping": [ {
        "map": "(see OBX.6 etc.) / CQ.2",
        "identity": "v2"
      }, {
        "map": "PQ.code, MO.currency, PQ.translation.code",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "code"
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Dosage.doseAndRate.dose[x]:doseQuantity.code",
      "comment": "The preferred system is UCUM, but SNOMED CT can also be used (for customary units) or ISO 4217 for currency.  The context of use may additionally require a code from a particular system.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.code"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.doseAndRate.dose[x]",
      "requirements": "The amount of therapeutic or other substance given at one administration event.",
      "min": 0,
      "definition": "Amount of medication per dose.",
      "isModifier": false,
      "short": "Amount of medication per dose",
      "mapping": [ {
        "map": "RXO-2, RXE-3",
        "identity": "v2"
      }, {
        "map": ".doseQuantity",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Range"
      } ],
      "mustSupport": true,
      "sliceName": "doseRange",
      "max": "1",
      "id": "Dosage.doseAndRate.dose[x]:doseRange",
      "comment": "Note that this specifies the quantity of the specified medication, not the quantity for each active ingredient(s). Each ingredient amount can be communicated in the Medication resource. For example, if one wants to communicate that a tablet was 375 mg, where the dose was one tablet, you can use the Medication resource to document that the tablet was comprised of 375 mg of drug XYZ. Alternatively if the dose was 375 mg, then you may only need to use the Medication resource to indicate this was a tablet. If the example were an IV such as dopamine and you wanted to communicate that 400mg of dopamine was mixed in 500 ml of some IV solution, then this would all be communicated in the Medication resource. If the administration is not intended to be instantaneous (rate is present or timing has a duration), this can be specified to convey the total amount to be administered over the period of time as indicated by the schedule e.g. 500 ml in dose, with timing used to convey that this should be done over 4 hours.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Dosage.doseAndRate.dose[x]"
      },
      "isSummary": true
    }, {
      "path": "Dosage.doseAndRate.dose[x].id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Dosage.doseAndRate.dose[x]:doseRange.id",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "xpath": "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Dosage.doseAndRate.dose[x].extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "slicing": {
        "rules": "open",
        "description": "Extensions are always sliced by (at least) url",
        "discriminator": [ {
          "path": "url",
          "type": "value"
        } ]
      },
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Dosage.doseAndRate.dose[x]:doseRange.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.doseAndRate.dose[x].low",
      "min": 0,
      "definition": "The low limit. The boundary is inclusive.",
      "isModifier": false,
      "short": "Low limit",
      "mapping": [ {
        "map": "NR.1",
        "identity": "v2"
      }, {
        "map": "./low",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Quantity",
        "profile": [ "http://hl7.org/fhir/StructureDefinition/SimpleQuantity|4.0.1" ]
      } ],
      "mustSupport": true,
      "binding": {
        "strength": "required",
        "valueSet": "http://ig.fhir.de/igs/medication/ValueSet/DosageDoseQuantityDE"
      },
      "max": "1",
      "id": "Dosage.doseAndRate.dose[x]:doseRange.low",
      "comment": "If the low element is missing, the low boundary is not known.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Range.low"
      },
      "isSummary": true
    }, {
      "path": "Dosage.doseAndRate.dose[x].low.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Dosage.doseAndRate.dose[x]:doseRange.low.id",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "xpath": "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Dosage.doseAndRate.dose[x].low.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "slicing": {
        "rules": "open",
        "description": "Extensions are always sliced by (at least) url",
        "discriminator": [ {
          "path": "url",
          "type": "value"
        } ]
      },
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Dosage.doseAndRate.dose[x]:doseRange.low.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.doseAndRate.dose[x].low.value",
      "requirements": "Precision is handled implicitly in almost all cases of measurement.",
      "min": 0,
      "definition": "The value of the measured amount. The value includes an implicit precision in the presentation of the value.",
      "isModifier": false,
      "short": "Numerical value (with implicit precision)",
      "mapping": [ {
        "map": "SN.2  / CQ - N/A",
        "identity": "v2"
      }, {
        "map": "PQ.value, CO.value, MO.value, IVL.high or IVL.low depending on the value",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "decimal"
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Dosage.doseAndRate.dose[x]:doseRange.low.value",
      "comment": "The implicit precision in the value should always be honored. Monetary values have their own rules for handling precision (refer to standard accounting text books).",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.value"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.doseAndRate.dose[x].low.comparator",
      "requirements": "Need a framework for handling measures where the value is <5ug/L or >400mg/L due to the limitations of measuring methodology.",
      "min": 0,
      "definition": "Not allowed to be used in this context",
      "isModifier": true,
      "short": "< | <= | >= | > - how to understand the value",
      "mapping": [ {
        "map": "SN.1  / CQ.1",
        "identity": "v2"
      }, {
        "map": "IVL properties",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "code"
      } ],
      "meaningWhenMissing": "If there is no comparator, then there is no modification of the value",
      "binding": {
        "strength": "required",
        "valueSet": "http://hl7.org/fhir/ValueSet/quantity-comparator|4.0.1",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "QuantityComparator"
        } ],
        "description": "How the Quantity should be understood and represented."
      },
      "max": "0",
      "id": "Dosage.doseAndRate.dose[x]:doseRange.low.comparator",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.comparator"
      },
      "isModifierReason": "This is labeled as \"Is Modifier\" because the comparator modifies the interpretation of the value significantly. If there is no comparator, then there is no modification of the value",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.doseAndRate.dose[x].low.unit",
      "requirements": "There are many representations for units of measure and in many contexts, particular representations are fixed and required. I.e. mcg for micrograms.",
      "min": 0,
      "definition": "A human-readable form of the unit.",
      "isModifier": false,
      "short": "Unit representation",
      "mapping": [ {
        "map": "(see OBX.6 etc.) / CQ.2",
        "identity": "v2"
      }, {
        "map": "PQ.unit",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "string"
      } ],
      "mustSupport": true,
      "extension": [ {
        "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
        "valueBoolean": true
      } ],
      "max": "1",
      "id": "Dosage.doseAndRate.dose[x]:doseRange.low.unit",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.unit"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.doseAndRate.dose[x].low.system",
      "requirements": "Need to know the system that defines the coded form of the unit.",
      "min": 0,
      "definition": "The identification of the system that provides the coded form of the unit.",
      "isModifier": false,
      "short": "System that defines coded unit form",
      "mapping": [ {
        "map": "(see OBX.6 etc.) / CQ.2",
        "identity": "v2"
      }, {
        "map": "CO.codeSystem, PQ.translation.codeSystem",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "uri"
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Dosage.doseAndRate.dose[x]:doseRange.low.system",
      "condition": [ "qty-3" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.system"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.doseAndRate.dose[x].low.code",
      "requirements": "Need a computable form of the unit that is fixed across all forms. UCUM provides this for quantities, but SNOMED CT provides many units of interest.",
      "min": 0,
      "definition": "A computer processable form of the unit in some unit representation system.",
      "isModifier": false,
      "short": "Coded form of the unit",
      "mapping": [ {
        "map": "(see OBX.6 etc.) / CQ.2",
        "identity": "v2"
      }, {
        "map": "PQ.code, MO.currency, PQ.translation.code",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "code"
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Dosage.doseAndRate.dose[x]:doseRange.low.code",
      "comment": "The preferred system is UCUM, but SNOMED CT can also be used (for customary units) or ISO 4217 for currency.  The context of use may additionally require a code from a particular system.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.code"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.doseAndRate.dose[x].high",
      "min": 0,
      "definition": "The high limit. The boundary is inclusive.",
      "isModifier": false,
      "short": "High limit",
      "mapping": [ {
        "map": "NR.2",
        "identity": "v2"
      }, {
        "map": "./high",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Quantity",
        "profile": [ "http://hl7.org/fhir/StructureDefinition/SimpleQuantity|4.0.1" ]
      } ],
      "mustSupport": true,
      "binding": {
        "strength": "required",
        "valueSet": "http://ig.fhir.de/igs/medication/ValueSet/DosageDoseQuantityDE"
      },
      "max": "1",
      "id": "Dosage.doseAndRate.dose[x]:doseRange.high",
      "comment": "If the high element is missing, the high boundary is not known.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Range.high"
      },
      "isSummary": true
    }, {
      "path": "Dosage.doseAndRate.dose[x].high.id",
      "min": 0,
      "definition": "Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.",
      "isModifier": false,
      "short": "Unique id for inter-element referencing",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "http://hl7.org/fhirpath/System.String",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/structuredefinition-fhir-type",
          "valueUrl": "string"
        } ]
      } ],
      "representation": [ "xmlAttr" ],
      "max": "1",
      "id": "Dosage.doseAndRate.dose[x]:doseRange.high.id",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Element.id"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      }, {
        "key": "ext-1",
        "human": "Must have either extensions or value[x], not both",
        "xpath": "exists(f:extension)!=exists(f:*[starts-with(local-name(.), \"value\")])",
        "source": "http://hl7.org/fhir/StructureDefinition/Extension",
        "severity": "error",
        "expression": "extension.exists() != value.exists()"
      } ],
      "path": "Dosage.doseAndRate.dose[x].high.extension",
      "min": 0,
      "definition": "May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "isModifier": false,
      "short": "Additional content defined by implementations",
      "mapping": [ {
        "map": "n/a",
        "identity": "rim"
      } ],
      "slicing": {
        "rules": "open",
        "description": "Extensions are always sliced by (at least) url",
        "discriminator": [ {
          "path": "url",
          "type": "value"
        } ]
      },
      "type": [ {
        "code": "Extension"
      } ],
      "alias": [ "extensions", "user content" ],
      "max": "*",
      "id": "Dosage.doseAndRate.dose[x]:doseRange.high.extension",
      "comment": "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "base": {
        "max": "*",
        "min": 0,
        "path": "Element.extension"
      },
      "isSummary": false
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.doseAndRate.dose[x].high.value",
      "requirements": "Precision is handled implicitly in almost all cases of measurement.",
      "min": 0,
      "definition": "The value of the measured amount. The value includes an implicit precision in the presentation of the value.",
      "isModifier": false,
      "short": "Numerical value (with implicit precision)",
      "mapping": [ {
        "map": "SN.2  / CQ - N/A",
        "identity": "v2"
      }, {
        "map": "PQ.value, CO.value, MO.value, IVL.high or IVL.low depending on the value",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "decimal"
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Dosage.doseAndRate.dose[x]:doseRange.high.value",
      "comment": "The implicit precision in the value should always be honored. Monetary values have their own rules for handling precision (refer to standard accounting text books).",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.value"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.doseAndRate.dose[x].high.comparator",
      "requirements": "Need a framework for handling measures where the value is <5ug/L or >400mg/L due to the limitations of measuring methodology.",
      "min": 0,
      "definition": "Not allowed to be used in this context",
      "isModifier": true,
      "short": "< | <= | >= | > - how to understand the value",
      "mapping": [ {
        "map": "SN.1  / CQ.1",
        "identity": "v2"
      }, {
        "map": "IVL properties",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "code"
      } ],
      "meaningWhenMissing": "If there is no comparator, then there is no modification of the value",
      "binding": {
        "strength": "required",
        "valueSet": "http://hl7.org/fhir/ValueSet/quantity-comparator|4.0.1",
        "extension": [ {
          "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString": "QuantityComparator"
        } ],
        "description": "How the Quantity should be understood and represented."
      },
      "max": "0",
      "id": "Dosage.doseAndRate.dose[x]:doseRange.high.comparator",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.comparator"
      },
      "isModifierReason": "This is labeled as \"Is Modifier\" because the comparator modifies the interpretation of the value significantly. If there is no comparator, then there is no modification of the value",
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.doseAndRate.dose[x].high.unit",
      "requirements": "There are many representations for units of measure and in many contexts, particular representations are fixed and required. I.e. mcg for micrograms.",
      "min": 0,
      "definition": "A human-readable form of the unit.",
      "isModifier": false,
      "short": "Unit representation",
      "mapping": [ {
        "map": "(see OBX.6 etc.) / CQ.2",
        "identity": "v2"
      }, {
        "map": "PQ.unit",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "string"
      } ],
      "mustSupport": true,
      "extension": [ {
        "url": "http://hl7.org/fhir/StructureDefinition/elementdefinition-translatable",
        "valueBoolean": true
      } ],
      "max": "1",
      "id": "Dosage.doseAndRate.dose[x]:doseRange.high.unit",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.unit"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.doseAndRate.dose[x].high.system",
      "requirements": "Need to know the system that defines the coded form of the unit.",
      "min": 0,
      "definition": "The identification of the system that provides the coded form of the unit.",
      "isModifier": false,
      "short": "System that defines coded unit form",
      "mapping": [ {
        "map": "(see OBX.6 etc.) / CQ.2",
        "identity": "v2"
      }, {
        "map": "CO.codeSystem, PQ.translation.codeSystem",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "uri"
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Dosage.doseAndRate.dose[x]:doseRange.high.system",
      "condition": [ "qty-3" ],
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.system"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.doseAndRate.dose[x].high.code",
      "requirements": "Need a computable form of the unit that is fixed across all forms. UCUM provides this for quantities, but SNOMED CT provides many units of interest.",
      "min": 0,
      "definition": "A computer processable form of the unit in some unit representation system.",
      "isModifier": false,
      "short": "Coded form of the unit",
      "mapping": [ {
        "map": "(see OBX.6 etc.) / CQ.2",
        "identity": "v2"
      }, {
        "map": "PQ.code, MO.currency, PQ.translation.code",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "code"
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Dosage.doseAndRate.dose[x]:doseRange.high.code",
      "comment": "The preferred system is UCUM, but SNOMED CT can also be used (for customary units) or ISO 4217 for currency.  The context of use may additionally require a code from a particular system.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Quantity.code"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.doseAndRate.rate[x]",
      "requirements": "Identifies the speed with which the medication was or will be introduced into the patient. Typically the rate for an infusion e.g. 100 ml per 1 hour or 100 ml/hr.  May also be expressed as a rate per unit of time e.g. 500 ml per 2 hours.   Other examples: 200 mcg/min or 200 mcg/1 minute; 1 liter/8 hours.  Sometimes, a rate can imply duration when expressed as total volume / duration (e.g.  500mL/2 hours implies a duration of 2 hours).  However, when rate doesn't imply duration (e.g. 250mL/hour), then the timing.repeat.duration is needed to convey the infuse over time period.",
      "min": 0,
      "definition": "Amount of medication per unit of time.",
      "isModifier": false,
      "short": "Amount of medication per unit of time",
      "mapping": [ {
        "map": "RXE22, RXE23, RXE-24",
        "identity": "v2"
      }, {
        "map": ".rateQuantity",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Ratio"
      }, {
        "code": "Range"
      }, {
        "code": "Quantity",
        "profile": [ "http://hl7.org/fhir/StructureDefinition/SimpleQuantity|4.0.1" ]
      } ],
      "max": "1",
      "id": "Dosage.doseAndRate.rate[x]",
      "comment": "It is possible to supply both a rate and a doseQuantity to provide full details about how the medication is to be administered and supplied. If the rate is intended to change over time, depending on local rules/regulations, each change should be captured as a new version of the MedicationRequest with an updated rate, or captured with a new MedicationRequest with the new rate.\r\rIt is possible to specify a rate over time (for example, 100 ml/hour) using either the rateRatio and rateQuantity.  The rateQuantity approach requires systems to have the capability to parse UCUM grammer where ml/hour is included rather than a specific ratio where the time is specified as the denominator.  Where a rate such as 500ml over 2 hours is specified, the use of rateRatio may be more semantically correct than specifying using a rateQuantity of 250 mg/hour.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Dosage.doseAndRate.rate[x]"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.maxDosePerPeriod",
      "requirements": "The maximum total quantity of a therapeutic substance that may be administered to a subject over the period of time.  For example, 1000mg in 24 hours.",
      "min": 0,
      "definition": "Upper limit on medication per unit of time.",
      "isModifier": false,
      "short": "Maximale Dosis pro Zeitraum",
      "mapping": [ {
        "map": "RXO-23, RXE-19",
        "identity": "v2"
      }, {
        "map": ".maxDoseQuantity",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Ratio"
      } ],
      "mustSupport": true,
      "max": "1",
      "id": "Dosage.maxDosePerPeriod",
      "comment": "This is intended for use as an adjunct to the dosage when there is an upper cap.  For example \"2 tablets every 4 hours to a maximum of 8/day\".",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Dosage.maxDosePerPeriod"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.maxDosePerAdministration",
      "requirements": "The maximum total quantity of a therapeutic substance that may be administered to a subject per administration.",
      "min": 0,
      "definition": "Upper limit on medication per administration.",
      "isModifier": false,
      "short": "Upper limit on medication per administration",
      "mapping": [ {
        "map": "not supported",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Quantity",
        "profile": [ "http://hl7.org/fhir/StructureDefinition/SimpleQuantity|4.0.1" ]
      } ],
      "max": "1",
      "id": "Dosage.maxDosePerAdministration",
      "comment": "This is intended for use as an adjunct to the dosage when there is an upper cap.  For example, a body surface area related dose with a maximum amount, such as 1.5 mg/m2 (maximum 2 mg) IV over 5 – 10 minutes would have doseQuantity of 1.5 mg/m2 and maxDosePerAdministration of 2 mg.",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Dosage.maxDosePerAdministration"
      },
      "isSummary": true
    }, {
      "constraint": [ {
        "key": "ele-1",
        "human": "All FHIR elements must have a @value or children",
        "xpath": "@value|f:*|h:div",
        "source": "http://hl7.org/fhir/StructureDefinition/Element",
        "severity": "error",
        "expression": "hasValue() or (children().count() > id.count())"
      } ],
      "path": "Dosage.maxDosePerLifetime",
      "requirements": "The maximum total quantity of a therapeutic substance that may be administered per lifetime of the subject.",
      "min": 0,
      "definition": "Upper limit on medication per lifetime of the patient.",
      "isModifier": false,
      "short": "Upper limit on medication per lifetime of the patient",
      "mapping": [ {
        "map": "not supported",
        "identity": "rim"
      } ],
      "type": [ {
        "code": "Quantity",
        "profile": [ "http://hl7.org/fhir/StructureDefinition/SimpleQuantity|4.0.1" ]
      } ],
      "max": "1",
      "id": "Dosage.maxDosePerLifetime",
      "base": {
        "max": "1",
        "min": 0,
        "path": "Dosage.maxDosePerLifetime"
      },
      "isSummary": true
    } ],
    "extension": [ {
      "url": "http://hl7.org/fhir/tools/StructureDefinition/snapshot-base-version",
      "valueString": "4.0.1"
    } ]
  },
  "status": "active",
  "id": "1b8a6b05-384f-4f95-97b2-97dc55f472c7",
  "kind": "complex-type",
  "url": "http://ig.fhir.de/igs/medication/StructureDefinition/DosageDE",
  "version": "2.0.0-ballot",
  "differential": {
    "element": [ {
      "id": "Dosage",
      "path": "Dosage",
      "constraint": [ {
        "key": "DosageStructuredOrFreeTextWarning",
        "human": "A dosage must be given either as free text only or as complete structured information only; mixing both is not allowed.",
        "source": "http://ig.fhir.de/igs/medication/StructureDefinition/DosageDE",
        "severity": "warning",
        "expression": "(%resource.ofType(MedicationRequest).dosageInstruction | \n %resource.ofType(MedicationDispense).dosageInstruction | \n %resource.ofType(MedicationStatement).dosage).all(\n  (text.exists() and timing.empty() and doseAndRate.empty()) or\n  (text.empty() and (timing.exists() or doseAndRate.exists()))\n)"
      }, {
        "key": "DosageStructuredRequiresBothWarning",
        "human": "If a structured dosage is given, both timing and doseAndRate should be present. For pure as-needed dosages, doseAndRate may be given without timing.",
        "source": "http://ig.fhir.de/igs/medication/StructureDefinition/DosageDE",
        "severity": "warning",
        "expression": "(%resource.ofType(MedicationRequest).dosageInstruction | \n %resource.ofType(MedicationDispense).dosageInstruction | \n %resource.ofType(MedicationStatement).dosage).all(\n  (timing.exists() implies doseAndRate.exists()) and\n  (doseAndRate.exists() implies (\n    timing.exists() or\n    asNeeded.ofType(boolean) = true or\n    extension.where(url='http://hl7.org/fhir/5.0/StructureDefinition/extension-Dosage.asNeededFor').exists()\n  ))\n)"
      }, {
        "key": "DosageDoseUnitSameCodeWarning",
        "human": "The dose unit should be the same across all dosages.",
        "source": "http://ig.fhir.de/igs/medication/StructureDefinition/DosageDE",
        "severity": "warning",
        "expression": "(%resource.ofType(MedicationRequest).dosageInstruction | %resource.ofType(MedicationDispense).dosageInstruction | %resource.ofType(MedicationStatement).dosage).all(\ndoseAndRate.exists() implies\n  (\n    (%resource.ofType(MedicationRequest).dosageInstruction | %resource.ofType(MedicationDispense).dosageInstruction | %resource.ofType(MedicationStatement).dosage).doseAndRate.dose.ofType(Quantity).code | \n    (%resource.ofType(MedicationRequest).dosageInstruction | %resource.ofType(MedicationDispense).dosageInstruction | %resource.ofType(MedicationStatement).dosage).doseAndRate.dose.ofType(Range).low.code | \n    (%resource.ofType(MedicationRequest).dosageInstruction | %resource.ofType(MedicationDispense).dosageInstruction | %resource.ofType(MedicationStatement).dosage).doseAndRate.dose.ofType(Range).high.code\n  ).distinct().count() = 1\n)"
      }, {
        "key": "DosageDoseValuePositiveWarning",
        "human": "doseQuantity.value and doseRange.high.value should be greater than 0. The value 0 is additionally allowed for doseRange.low.value only.",
        "source": "http://ig.fhir.de/igs/medication/StructureDefinition/DosageDE",
        "severity": "warning",
        "expression": "doseAndRate.all(\n  dose.ofType(Quantity).value.all($this > 0) and\n  dose.ofType(Range).low.value.all($this >= 0) and\n  dose.ofType(Range).high.value.all($this > 0)\n)"
      }, {
        "key": "DosageFourSlotPatternInTextWarning",
        "human": "A four-slot dosing schema (Viererschema, e.g. 1-1-1-1) was detected in Dosage.text. Please check whether it can be represented structurally.",
        "source": "http://ig.fhir.de/igs/medication/StructureDefinition/DosageDE",
        "severity": "warning",
        "expression": "text.exists() implies text.matches('.*\\\\d+\\\\s*[-–]\\\\s*\\\\d+\\\\s*[-–]\\\\s*\\\\d+\\\\s*[-–]\\\\s*\\\\d+.*').not()"
      }, {
        "key": "FreeTextSingleDosageOnlyWarning",
        "human": "If a dosage is given as pure free text, there should be exactly one Dosage element.",
        "source": "http://ig.fhir.de/igs/medication/StructureDefinition/DosageDE",
        "severity": "warning",
        "expression": "(\n  (%resource.ofType(MedicationRequest).dosageInstruction |\n   %resource.ofType(MedicationDispense).dosageInstruction |\n   %resource.ofType(MedicationStatement).dosage\n  ).exists(text.exists() and timing.empty() and doseAndRate.empty())\n)\nimplies\n(\n  (%resource.ofType(MedicationRequest).dosageInstruction |\n   %resource.ofType(MedicationDispense).dosageInstruction |\n   %resource.ofType(MedicationStatement).dosage\n  ).count() = 1\n)"
      }, {
        "key": "dos-1",
        "human": "AsNeededFor can only be set if AsNeeded is empty or true",
        "source": "http://ig.fhir.de/igs/medication/StructureDefinition/DosageDE",
        "severity": "error",
        "expression": "extension.where(url='http://hl7.org/fhir/5.0/StructureDefinition/extension-Dosage.asNeededFor').empty() or asNeeded.empty() or asNeeded"
      } ]
    }, {
      "path": "Dosage.extension",
      "min": 0,
      "definition": "Gibt die Indikation für die Bedarfsdosierung an.",
      "short": "Indikation für die Bedarfsdosierung",
      "type": [ {
        "code": "Extension",
        "profile": [ "http://hl7.org/fhir/5.0/StructureDefinition/extension-Dosage.asNeededFor" ]
      } ],
      "mustSupport": true,
      "sliceName": "asNeededFor",
      "max": "*",
      "id": "Dosage.extension:asNeededFor"
    }, {
      "id": "Dosage.extension:asNeededFor.value[x].text",
      "path": "Dosage.extension.value[x].text",
      "mustSupport": true
    }, {
      "id": "Dosage.modifierExtension",
      "path": "Dosage.modifierExtension",
      "slicing": {
        "rules": "open",
        "ordered": false,
        "discriminator": [ {
          "path": "url",
          "type": "value"
        } ]
      }
    }, {
      "path": "Dosage.modifierExtension",
      "min": 0,
      "definition": "Gibt den Mindestabstand zwischen zwei Gaben einer Bedarfsmedikation an.",
      "short": "Mindestabstand zwischen zwei Gaben",
      "type": [ {
        "code": "Extension",
        "profile": [ "http://ig.fhir.de/igs/medication/StructureDefinition/MinimumIntervalBetweenAdministrations" ]
      } ],
      "mustSupport": true,
      "sliceName": "minimumIntervalBetweenAdministrations",
      "max": "1",
      "id": "Dosage.modifierExtension:minimumIntervalBetweenAdministrations"
    }, {
      "id": "Dosage.modifierExtension:minimumIntervalBetweenAdministrations.value[x].unit",
      "path": "Dosage.modifierExtension.value[x].unit",
      "mustSupport": true
    }, {
      "id": "Dosage.modifierExtension:minimumIntervalBetweenAdministrations.value[x].system",
      "path": "Dosage.modifierExtension.value[x].system",
      "mustSupport": true
    }, {
      "id": "Dosage.modifierExtension:minimumIntervalBetweenAdministrations.value[x].code",
      "path": "Dosage.modifierExtension.value[x].code",
      "mustSupport": true
    }, {
      "id": "Dosage.text",
      "path": "Dosage.text",
      "short": "Freitext-Dosierungsanweisungen, z. B. 'Maximal 3x täglich 1 Stück bei Bedarf'",
      "comment": "Die Freitextdosierung sollte nur angegeben werden, wenn aufgrund der Komplexität keine strukturierte Dosierung möglich ist, um widersprüchliche Anweisungen zu vermeiden.",
      "definition": "Freitext-Dosierungsanweisungen, z. B. 'Maximal 3x täglich 1 Stück bei Bedarf'. Als Quelle dient hier ausschließlich der Arzt oder Apotheker",
      "mustSupport": true
    }, {
      "id": "Dosage.patientInstruction",
      "path": "Dosage.patientInstruction",
      "short": "Ergänzende Anwendungshinweise für Patientinnen und Patienten",
      "comment": "Dieses Feld dient ausschließlich für zusätzliche Instruktionen, die nicht bereits eindeutig über strukturierte Dosierungsangaben abbildbar sind, z. B. qualitative oder situative Hinweise.",
      "definition": "Ergänzende, nicht strukturiert abbildbare Anwendungshinweise für die sichere, korrekte oder verständliche Anwendung des Arzneimittels.",
      "mustSupport": true
    }, {
      "id": "Dosage.timing",
      "path": "Dosage.timing",
      "type": [ {
        "code": "Timing",
        "profile": [ "http://ig.fhir.de/igs/medication/StructureDefinition/TimingDE" ]
      } ],
      "short": "Wann das Medikament verabreicht werden soll",
      "comment": "Um widersprüchliche Anweisungen zu vermeiden, ist entweder Dosage.timing oder Dosage.text zu befüllen. Falls eine strukturierte Dosierung als Text abgebildet werden soll ist dafür die GeneratedDosageInstructionsMeta Extension zu verwenden.",
      "definition": "Wann das Medikament verabreicht werden soll.",
      "mustSupport": true
    }, {
      "id": "Dosage.asNeeded[x]",
      "path": "Dosage.asNeeded[x]",
      "type": [ {
        "code": "boolean"
      } ],
      "short": "Bedarfsdosierung (nur Ja/Nein-Angabe)",
      "definition": "Gibt an, ob es sich um eine Bedarfsdosierung handelt. Es ist nur eine Ja/Nein-Angabe erlaubt. Die Abbildung der Indikation erfolgt über die Extension asNeededFor.",
      "mustSupport": true
    }, {
      "id": "Dosage.doseAndRate",
      "path": "Dosage.doseAndRate",
      "short": "Menge des verabreichten Medikaments",
      "definition": "Die verabreichte Menge des Medikaments.",
      "mustSupport": true
    }, {
      "id": "Dosage.doseAndRate.dose[x]",
      "path": "Dosage.doseAndRate.dose[x]",
      "slicing": {
        "rules": "open",
        "ordered": false,
        "discriminator": [ {
          "path": "$this",
          "type": "type"
        } ]
      },
      "mustSupport": true
    }, {
      "path": "Dosage.doseAndRate.dose[x]",
      "min": 0,
      "definition": "Menge des Medikaments pro Dosis.",
      "short": "Menge des Medikaments pro Dosis",
      "type": [ {
        "code": "Quantity",
        "profile": [ "http://hl7.org/fhir/StructureDefinition/SimpleQuantity" ]
      } ],
      "mustSupport": true,
      "sliceName": "doseQuantity",
      "binding": {
        "strength": "required",
        "valueSet": "http://ig.fhir.de/igs/medication/ValueSet/DosageDoseQuantityDE"
      },
      "max": "1",
      "id": "Dosage.doseAndRate.dose[x]:doseQuantity",
      "comment": "Beachten Sie, dass dies die Menge des angegebenen Medikaments angibt, nicht die Menge für die einzelnen Wirkstoffe. Jede Wirkstoffmenge kann in der Medication-Ressource kommuniziert werden. Zum Beispiel, wenn man angeben möchte, dass eine Tablette 375 mg enthält und die Dosis eine Tablette beträgt, kann man die Medication-Ressource verwenden, um zu dokumentieren, dass die Tablette aus 375 mg des Wirkstoffs XYZ besteht. Alternativ, wenn die Dosis 375 mg beträgt, muss man möglicherweise nur angeben, dass es sich um eine Tablette handelt. Bei einer Infusion wie Dopamin, bei der 400 mg Dopamin in 500 ml einer Infusionslösung gemischt werden, würde dies alles in der Medication-Ressource kommuniziert werden. Wenn die Verabreichung nicht als sofortig vorgesehen ist (Rate ist vorhanden oder Timing hat eine Dauer), kann dies angegeben werden, um die Gesamtmenge anzugeben, die über den im Zeitplan angegebenen Zeitraum verabreicht werden soll, z. B. 500 ml in der Dosis, wobei Timing verwendet wird, um anzugeben, dass dies über 4 Stunden erfolgen soll."
    }, {
      "id": "Dosage.doseAndRate.dose[x]:doseQuantity.value",
      "path": "Dosage.doseAndRate.dose[x].value",
      "mustSupport": true
    }, {
      "id": "Dosage.doseAndRate.dose[x]:doseQuantity.unit",
      "path": "Dosage.doseAndRate.dose[x].unit",
      "mustSupport": true
    }, {
      "id": "Dosage.doseAndRate.dose[x]:doseQuantity.system",
      "path": "Dosage.doseAndRate.dose[x].system",
      "mustSupport": true
    }, {
      "id": "Dosage.doseAndRate.dose[x]:doseQuantity.code",
      "path": "Dosage.doseAndRate.dose[x].code",
      "mustSupport": true
    }, {
      "id": "Dosage.doseAndRate.dose[x]:doseRange",
      "max": "1",
      "min": 0,
      "path": "Dosage.doseAndRate.dose[x]",
      "type": [ {
        "code": "Range"
      } ],
      "sliceName": "doseRange",
      "mustSupport": true
    }, {
      "id": "Dosage.doseAndRate.dose[x]:doseRange.low",
      "path": "Dosage.doseAndRate.dose[x].low",
      "binding": {
        "strength": "required",
        "valueSet": "http://ig.fhir.de/igs/medication/ValueSet/DosageDoseQuantityDE"
      },
      "mustSupport": true
    }, {
      "id": "Dosage.doseAndRate.dose[x]:doseRange.low.value",
      "path": "Dosage.doseAndRate.dose[x].low.value",
      "mustSupport": true
    }, {
      "id": "Dosage.doseAndRate.dose[x]:doseRange.low.unit",
      "path": "Dosage.doseAndRate.dose[x].low.unit",
      "mustSupport": true
    }, {
      "id": "Dosage.doseAndRate.dose[x]:doseRange.low.system",
      "path": "Dosage.doseAndRate.dose[x].low.system",
      "mustSupport": true
    }, {
      "id": "Dosage.doseAndRate.dose[x]:doseRange.low.code",
      "path": "Dosage.doseAndRate.dose[x].low.code",
      "mustSupport": true
    }, {
      "id": "Dosage.doseAndRate.dose[x]:doseRange.high",
      "path": "Dosage.doseAndRate.dose[x].high",
      "binding": {
        "strength": "required",
        "valueSet": "http://ig.fhir.de/igs/medication/ValueSet/DosageDoseQuantityDE"
      },
      "mustSupport": true
    }, {
      "id": "Dosage.doseAndRate.dose[x]:doseRange.high.value",
      "path": "Dosage.doseAndRate.dose[x].high.value",
      "mustSupport": true
    }, {
      "id": "Dosage.doseAndRate.dose[x]:doseRange.high.unit",
      "path": "Dosage.doseAndRate.dose[x].high.unit",
      "mustSupport": true
    }, {
      "id": "Dosage.doseAndRate.dose[x]:doseRange.high.system",
      "path": "Dosage.doseAndRate.dose[x].high.system",
      "mustSupport": true
    }, {
      "id": "Dosage.doseAndRate.dose[x]:doseRange.high.code",
      "path": "Dosage.doseAndRate.dose[x].high.code",
      "mustSupport": true
    }, {
      "id": "Dosage.maxDosePerPeriod",
      "path": "Dosage.maxDosePerPeriod",
      "short": "Maximale Dosis pro Zeitraum",
      "mustSupport": true
    } ]
  },
  "contact": [ {
    "name": "HL7 Deutschland e.V.",
    "telecom": [ {
      "value": "https://hl7.de",
      "system": "url"
    } ]
  } ],
  "baseDefinition": "http://hl7.org/fhir/StructureDefinition/Dosage"
}