{
  "description": "PharmGKB contains examples of evidence level concepts that are not conflated with clinical significance. These can be found on PharmGKB https://www.pharmgkb.org/page/clinAnnLevels. These examples are informational only, for copyright information contact the relevant source.",
  "_filename": "CodeSystem-pharmgkb-evidence-level-custom-cs.json",
  "package_name": "hl7.fhir.uv.genomics-reporting",
  "date": "2022-05-09T16:53:07+00:00",
  "publisher": "HL7 Clinical Genomics Working Group",
  "jurisdiction": [ {
    "coding": [ {
      "code": "001",
      "system": "http://unstats.un.org/unsd/methods/m49/m49.htm",
      "display": "World"
    } ]
  } ],
  "content": "complete",
  "name": "PharmGKBEvidenceLevelCustomCS",
  "type": null,
  "experimental": null,
  "resourceType": "CodeSystem",
  "title": "PharmGKB Evidence Level Example Codes",
  "package_version": "2.0.0",
  "status": "active",
  "id": "19a63756-73db-4e88-b97d-65564d165aea",
  "kind": null,
  "count": 6,
  "url": "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/pharmgkb-evidence-level-custom-cs",
  "concept": [ {
    "code": "1A",
    "display": "PGKB 1A",
    "definition": "High level of evidence. Supported by a guideline or FDA label with variant specific prescribing guidance. Additionally, supported by at least one publication."
  }, {
    "code": "1B",
    "display": "PGKB 1B",
    "definition": "High level of evidence. But, NOT supported by a guideline or FDA label with variant specific prescribing guidance. Additionally, supported by at least one publication."
  }, {
    "code": "2A",
    "display": "PGKB 2A",
    "definition": "Moderate level of evidence. Supported by being a KNOWN pharmacogene on https://www.pharmgkb.org/vips. Also, found in multiple studies but may have a minority of studies that did not support the majority opinion. Supported by at least two indpendent publications."
  }, {
    "code": "2B",
    "display": "PGKB 2B",
    "definition": "Moderate level of evidence. NOT in the list of very important, KNOWN pharmacogenes. Found in multiple studies but may have a minority of studies that did not support the majority opinion. Supported by at least two indpendent publications."
  }, {
    "code": "3",
    "display": "PGKB 3",
    "definition": "Low-level of evidence. Where either the assocation is based on a single study, failed to be reproduced, or preliminary evidence."
  }, {
    "code": "4",
    "display": "PGKB 4",
    "definition": "The evidence does not support an association between the variant and the drug phenotype. (negative)"
  } ],
  "caseSensitive": true,
  "version": "2.0.0",
  "contact": [ {
    "name": "HL7 Clinical Genomics Working Group",
    "telecom": [ {
      "value": "http://www.hl7.org/Special/committees/clingenomics",
      "system": "url"
    }, {
      "value": "cg@lists.HL7.org",
      "system": "email"
    } ]
  } ]
}